The mitogenic function of hepatitis B virus X protein resides within amino acids 51 to 140 and is modulated by N- and C-terminal regulatory regions

Journal of Virology

Volumn 80, Issue 21, 2006, Pages 10554-10564

  Li, Huajie ^a   Chi, Chia Yi ^a   Lee, Sook ^a   Andrisani, Ourania M ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; CYCLIN A; HEPATITIS B VIRUS X PROTEIN; TETRACYCLINE; VIRUS DNA;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CLONE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION REGULATION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALIGNANT TRANSFORMATION; MITOGENESIS; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN VARIANT; RETROVIRUS VECTOR; SENSITIZATION; VIRUS GENOME; WILD TYPE;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE; CYCLIN A; GENE EXPRESSION; GENES, VIRAL; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; MICE; MITOGENS; RECOMBINANT PROTEINS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TETRACYCLINE; TRANS-ACTIVATORS; TRANSFECTION;

HEPATITIS B VIRUS;

EID: 33750381428     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00661-06     Document Type: Article

References (48)

1. Andrisani, O. M. 1999. CREB-mediated transcriptional control. Crit. Rev. Eukaryot. Gene Expr. 9:19-32.
2. Andrisani, O. M., and S. Barnabas. 1999. The role of the transcriptional involvement of HBV pX in hepatocarcinogenesis. Int. J. Oncol. 15:373-379.
3. Arii, M., K. Takada, and K. Koike. 1992. Identification of three essential regions of hepatitis B virus X protein for trans-activation function. Oncogene 7:397-403.
4. Barnabas, S., and O. M. Andrisani. 2000. Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression. J. Virol. 74:83-90.
5. Barnabas, S., T. Hai, and O. M. Andrisani. 1997. The hepatitis B virus X protein enhances the DNA binding potential and transcription efficacy of bZip transcription factors. J. Biol. Chem. 272:20684-20690.
6. Beasley, R. P., L. Y. Hwang, C. C. Lin, and C. S. Chien. 1981. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 2:1129-1133.
7. Benn, J., and R. J. Schneider. 1994. Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc. Natl. Acad. Sci. USA 91:10350-10354.
8. Benn, J., and R. J. Schneider. 1995. Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls. Proc. Natl. Acad. Sci. USA 92:11215-11219.
9. Benn, J., F. Su, M. Doria, and R. J. Schneider. 1996. Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-related and c-Jun N-terminal mitogen-activated protein kinases. J. Virol. 70:4978-4985.
10. Bergametti, F., D. Sitterlin, and C. Transy. 2002. Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex. J. Virol. 76:6495-6501.
11. Bottazzi, M. E., M. Buzzai, X. Zhu, C. Desdouets, C. Bréchot, and R. K. Assoian. 2001. Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity. Mol. Cell. Biol. 21:7607-7616.
12. 1 transit via an Src kinase pathway. J. Virol. 75:4247-4257.
13. Bouchard, M. J., R. J. Puro, L. Wang, and R. J. Schneider. 2003. Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication. J. Virol. 77:7713-7719.
14. Bouchard, M. J., and R. J. Schneider. 2004. The enigmatic X gene of hepatitis B virus. J. Virol. 78:12725-12734.
15. Bouchard, M. J., L. Wang, and R. J. Schneider. 2001. Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 294:2376-2378.
16. Buendia, M. A. 1998. Hepatitis B viruses and cancerogenesis. Biomed. Pharmacother. 52:34-43.
17. Chen, H.-S., S. Kaneko, R. Girones, R. W. Anderson, W. E. Horbuckle, B. C. Tennant, P. J. Cote, J. L. Gerin, R. H. Purcell, and R. H. Miller. 1993. The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks. J. Virol. 67:1218-1226.
18. Cheong, J. H., M. Yi, Y. Lin, and S. Murakami. 1995. Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation. EMBO J. 14:143-150.
19. Chirillo, P., S. Pagano, G. Natoli, P. L. Puri, V. L. Burgio, C. Balsano, and M. Levrero. 1997. The hepatitis B virus X gene induces p53-mediated programmed cell death. Proc. Natl. Acad. Sci. USA 94:8162-8167.
20. Choi, B. H., G. T. Park, and H. M. Rho. 1999. Interaction of hepatitis B viral X protein and CCAAT/enhancer-binding protein α synergistically activates the hepatitis B viral enhancer II/pregenomic promoter. J. Biol. Chem. 274:2858-2865.
21. Dandri, M., P. Schirmacher, and C. E. Rogler. 1996. Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replication. J. Virol. 70:5246-5254.
22. Doria, M., N. Klein, R. Lucito, and R. J. Schneider. 1995. The hepatitis B virus is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO J. 14:4747-4757.
23. Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547-5551.
24. Haviv, I., M. Shamay, G. Doitsch, and Y. Shaul. 1998. Hepatitis B virus pX targets TFIIB in transcription coactivation. Mol. Cell. Biol. 18:1562-1569.
25. Klein, N. P., and R. J. Schneider. 1997. Activation of Src family kinases by hepatitis B virus HBx protein and coupled signal to Ras. Mol. Cell. Biol. 17:6427-6436.
26. Kozak, M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125-8148.
27. Kumar, V., N. Jayasuryan, and R. Kumar. 1996. A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function. Proc. Natl. Acad. Sci. USA 93:5647-5652.
28. Lee, S., C. Tarn, W.-H. Wang, S. Chen, R. L. Hullinger, and O. M. Andrisani. 2002. Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus non-transforming hepatocyte (AML12) cell lines. J. Biol. Chem. 277:8730-8740.
29. Lin, Y., T. Nomura, J. Cheong, D. Dorjsuren, K. Iida, and S. Murakami. 1997. Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5. J. Biol. Chem. 272:7132-7139.
30. Lucito, R., and R. J. Schneider. 1992. Hepatitis B virus X protein activates transcription factor NF-κB without a requirement for protein kinase. J. Virol. 66:983-991.
31. Murakami, S., J. H. Cheong, and S. Kaneko. 1994. Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein. J. Biol. Chem. 269:15118-15123.
32. Natoli, G., M. L. Avantaggiati, P. Chirillo, A. Costanzo, M. Artini, C. Balsano, and M. Levrero. 1994. Induction of the DNA-binding activity of c-Jun/c-Fos heterodimers by the hepatitis B virus transactivator pX. Mol. Cell. Biol. 14:989-998.
33. Nijhara, R., S. S. Jana, S. K. Goswami, V. Kumar, and D. P. Sarkar. 2001. An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver. FEBS Lett. 504:59-64.
34. Qadri, I., J. W. Conaway, R. C. Conaway, J. Schaack, and A. Siddiqui. 1996. Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH. Proc. Natl. Acad. Sci. USA 93:10578-10583.
35. Renner, M., A. Haniel, E. Burgelt, P. H. Hofschneider, and W. Koch. 1995. Transactivating function and expression of the X gene of the hepatitis B virus. J. Hepatol. 23:53-65.
36. Schlüter, V., M. Meyer, P. H. Hofschneider, R. Koshy, and W. F. Caselmann. 1994. Integrated hepatitis B virus X and 3′ truncated preS/S sequences derived from human hepatomas encode functionally active transactivators. Oncogene 9:3335-3344.
37. Schuster, R., W. H. Gerlich, and S. Schaefer. 2000. Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts. Oncogene 19:1173-1180.
38. Seto, E., P. J. Mitchell, and T. S. B. Yen. 1990. Transactivation of the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature 344:72-74.
39. Su, F., and R. J. Schneider. 1996. Hepatitis B virus HBx protein activates transcription factor NF-κB by acting on multiple cytoplasmic inhibitors of rel-related proteins. J. Virol. 70:4558-4566.
40. Tarn, C., M. L. Bilodeau, R. L. Hullinger, and O. M. Andrisani. 1999. Differential immediate early gene expression in conditional hepatitis B virus pX-transforming versus nontransforming hepatocyte cell lines. J. Biol. Chem. 274:2327-2336.
41. Tarn, C., L. Zou, R. L. Hullinger, and O. M. Andrisani. 2002. Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes. J. Virol. 76:9763-9772.
42. Tarn, C., S. Lee, Y. Hu, C. Ashendal, and O. M. Andrisani. 2001. Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML-12 hepatocytes. J. Biol. Chem. 276:34671-34680.
43. Tu, H., C. Bonura, C. Giannini, H. Mouly, P. Soussan, M. Kew, P. Paterlini-Bréchot, C. Bréchot, and D. Kremsdorf. 2001. Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res. 61:7803-7810.
44. Wang, W. H., G. Gregori, R. L. Hullinger, and O. M. Andrisani. 2004. Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase tumor necrosis factor (TNF) receptor 1/TNF-α expression. Mol. Cell. Biol. 24:10352-10365.
45. Williams, J. S., and O. M. Andrisani. 1995. The hepatitis B virus X protein targets the basic region leucine zipper domain of CREB. Proc. Natl. Acad. Sci. USA 92:3819-3823.
46. Wollersheim, M., U. Debelka, and P. H. Hofschneider. 1988. A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state. Oncogene 3:545-552.
47. Wu, J. C., G. Merlino, and N. Fausto. 1994. Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor α. Proc. Natl. Acad. Sci. USA 91:674-678.
48. Zoulim, F., J. Saputelli, and C. Seeger. 1994. Woodchuck hepatitis virus X protein is required for viral infection in vivo. J. Virol. 68:2026-2030.