Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins

Journal of Neural Transmission, Supplement

Volumn , Issue 70, 2006, Pages 205-208

  Hattori, N ^a   Machida, Y ^a   Sato, S ^a   Noda, K ^a   Iijima Kitami, M ^a   Kubo, S ^a   Mizuno, Y ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; DOPA; PARKIN;

CONFERENCE PAPER; DISEASE CLASSIFICATION; FAMILIAL DISEASE; GENETIC RISK; HUMAN; LEWY BODY; PARKINSON DISEASE; PRIORITY JOURNAL; STRIATONIGRAL DEGENERATION;

EID: 33750373346     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-211-45295-0_31     Document Type: Conference Paper

References (10)

1. Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304: 1328-1331
2. Dawson TM, Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302: 819-922
3. Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ et al. (2003) Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem 278: 43628-43635
4. Hattori N, Mizuno Y (2004) Pathogenetic mechanisms of parkin in Parkinson's disease. Lancet 364: 722-724
5. Itier JM, Ibanez P, Mena MA, Abbas N, Cohen-Salmon C, Bohme GA, Laville M, Pratt J, Corti O, Pradier L et al. (2003) Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse. Hum Mol Genet 12: 2277-2291
6. Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (2004) BAGS inhibits parkin and enhances dopaminergic neuron degeneration. Neuron 44: 931-945
7. Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392: 605-608
8. Machida Y, Chiba T, Takayanagi A, Tanaka Y, Asanuma M, Ogawa N, Koyama A, Iwatsubo T, Ito S, Jansen PH, Shimizu N, Tanaka K, Mizuno Y, Hattori N (2005) Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells. Biochem Biophys Res Commun 332: 233-240
9. Pickart CM (2001) Mechanisms underlying ubiquitination. Annu Rev Biochem 70: 503-533
10. Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K et al. (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 25: 302-305