Morphological changes and selective loss of motoneurons in the lumbar part of the spinal cord in a rat model of familial amyotrophic lateral sclerosis (fALS)

Folia Neuropathologica

Volumn 44, Issue 3, 2006, Pages 154-161

  Gadamski, Roman ^a   Chrapusta, Stanislaw J ^a   Wojda, Renata ^a   Grieb, Paweł ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Gliosis; Motoneuron disease; Reactive astrocyte; motoneuron; motoneuron

Indexed keywords

ALANINE; COPPER ZINC SUPEROXIDE DISMUTASE; GLYCINE;

ALPHA NERVE FIBER; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL LOSS; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; CYTOPATHOLOGY; DISEASE COURSE; FAMILIAL DISEASE; FEMALE; GAMMA MOTONEURON; GLIOSIS; HEMIZYGOSITY; LUMBAR SPINAL CORD; MALE; MICROSCOPY; MUTATIONAL ANALYSIS; NISSL SUBSTANCE; NONHUMAN; RAT; SPINAL CORD MOTONEURON; TRANSGENIC ANIMAL;

EID: 33750343160     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Aoki M, Kato S, Nagai M, Itoyama Y. Development of a rat model of amyotrophic lateral sclerosis expressing a human SOD1 transgene. Neuropathology 2005; 25: 365-370.
2. Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW. Onset and progression in inherited ALS determined by motor neurons and microglia. Science 2006; 312: 1389-1392.
3. Cudkowicz ME, McKenna-Yasek D, Sapp PE, Chin W, Geller B, Hayden DL, Schoenfeld DA, Hosler BA, Horvitz HR, Brown RH. Epidemiology of mutations in amyotrophic lateral sclerosis. Ann Neurol 1997; 41: 210-212.
4. G93A mutation. Folia Neuropathol 2006; 44:149-153.
5. Howland DS, Liu J, She Y, Goad B, Maragakis NJ, Kim B, Erickson J, Kulik J, DeVito L, Psaltis G, DeGennaro LJ, Cleveland DW, Rothstein JD. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci USA 2002; 99: 1604-1609.
6. Kato S, Shaw P, Wood-Allum C, Leigh PN, Show C. Amyotrophic lateral sclerosis. In: Dickson D (ed.) Neurodegeneration: the molecular pathology of dementia and movement disorders. Neuropathology Press, Basel 2003, pp. 350-368.
7. Kawamura Y, Dyck PJ, Shimono M, Okazaki H, Tateishi J, Doi H. Morphometric comparison of the vulnerability of peripheral motor and sensory neurons in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 1981; 40: 667-675.
8. Matsumoto A, Okada Y, Nakamichi M, Nakamura M, Toyama Y, Sobue G, Nagai M, Aoki M, Itoyama Y, Okano H. Disease progression of human SOD1 (G93A) transgenic ALS model rats. J Neurosci Res 2006; 83: 119-133.
9. Mohajeri MH, Figlewicz DA, Bohn MC. Selective loss of alpha motoneurons innervating the medial gastrocnemius muscle in a mouse model of amyotrophic lateral sclerosis. Exp Neurol 1998; 150: 329-336.
10. Nagai M, Aoki M, Miyoshi I, Kato M, Pasinelli P, Kasai N, Brown RH Jr, Itoyama Y. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. J Neurosci 2001; 21: 9246-9254.
11. Pehar M, Cassina P, Vargas MR, Castellanos R, Viera L, Beckman JS, Estevez AG, Barbeito L. Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis. J Neurochem 2004; 89: 464-473.
12. Rafałowska J. Are all new data referring to amyotrophic lateral sclerosis certain? Some doubts. Folia Neuropathol 2001; 39: 261-264.
13. Rafałowska J, Fidziańska A, Dziewulska D, Gadamski R, Ogonowska W, Grieb P. Progression of morphological changes within CNS in a transgenic rat model of familial amyotrophic lateral sclerosis. Folia Neuropathol 2006; 44(3): 162-174.
14. Rao SD, Weiss JH. Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis. Trends Neurosci 2004; 27: 17-23.
15. Sargsyan SA, Monk PN, Shaw PJ. Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis. Glia 2005; 51: 241-253.
16. 0 Symposium Europeen de Poliomyelitis, Oxford, E.A.P., Brussels 1962, pp. 241-245.
17. Solomon JN, Lewis CA, Ajami B, Corbel SY, Rossi FM, Krieger C. Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis. Glia 2006; 53: 744-753.
18. Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 1995; 14: 1105-1116.