Prevalence of glutamic acid decarboxylase antibody positivity and its association with insulin secretion and sensitivity in autoimmune thyroid disease: A pilot study

Experimental and Clinical Endocrinology and Diabetes

Volumn 114, Issue 8, 2006, Pages 412-416

  Aksoy, Duygu Yazgan ^a,b   Yurekli B P S ^a   Yildiz, B O ^a   Gedik, O ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b Angora Evleri   (Turkey)

Author keywords

GAD Ab; Hashimoto's thyroiditis; Islet cell autoantibody

Indexed keywords

GLUCOSE; GLUTAMATE DECARBOXYLASE ANTIBODY; INSULIN;

ARTICLE; AUTOIMMUNITY; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HASHIMOTO DISEASE; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PILOT STUDY; PREVALENCE; PRIORITY JOURNAL;

ADULT; AUTOANTIBODIES; FEMALE; GLUTAMATE DECARBOXYLASE; HASHIMOTO DISEASE; HUMANS; INSULIN; MALE; MIDDLE AGED;

EID: 33750310826     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-924153     Document Type: Article

References (44)

1. Achenbach P, Ziegler AG. Diabetes-related antibodies in euglycemic subjects. Best Pract Res Clin Endocrinol Metabol 2005; 19: 101-117
2. Aydin O, Apaydin FD, Bozdogan R, Pata C, Yalcinoglu O, Kanik A. Cytological correlation in patients who have a pre-diagnosis of thyroiditis ultrasonographically. Endocr Res 2003; 29: 97-106
3. Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, DeCamilli P. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347: 151-156
4. Bakker SJ, Ter Maaten JC, Popp-Snijders C, Heine RJ, Gans RO. Triiodothyronine: a link between the insulin resistance syndrome and blood pressure? J Hypertens 1999; 17: 1725-1730
5. Barrova H, Perusicova J, Hill M, Sterzl I, Vondra K, Masek Z. Anti-GAD positive patients with type 1 diabetes mellitus have higher prevalence of autoimmune thyroiditis than anti-GAD negative patients with type 1 and type 2 diabetes mellitus. Physiol Res 2004; 58: 279-286
6. Bergman RN, Phillips LS, Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 1981; 68: 1456-1467
7. Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974; 2: 1279-1283
8. Butler MH, Solimena M, Dirkx R Jr, Hayday A, De Camilli P. Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-mann syndrome. J Exp Med 1993; 178: 2097-2106
9. Fernandez-Castaner M, Molina A, Lopez-Jimenez L, Gomez JM, Soler J. presentation and early course of type 1 diabetes in patients with and without thyroid autoimmunity. Diabetes Care 1999; 22: 377-381
10. Franzese A, Buono P, Mascolo M, Leo AL, Valerio G. Thyroid autoimmunity starting during the course of type 1 diabetes denotes a subgroup of children with more severe diabetes. Diabetes Care 2000; 23: 1201-1202
11. Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, Knowler WC. The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. Diabetes Care 2000; 23: 1108-1112
12. Gambelunghe G, Forini F, Laureti S, Murdola G, Toraldo G, Santeusanio F, Brunetti P, Sanjeevi CB, Falorni A. Increased risk for endocrine autoimmunity in Italian type 2 diabetic patients with GAD65 autoantibodies. Clin Endocrinol (Oxf) 2000; 52: 565-573
13. Hallengren B, Falorni A, Landin-Olsson M, Lernmark A, Papadopoulos KI, Sundkvist G. Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients: at diagnosis and following treatment. Intern Med 1996; 239: 63-68
14. Hansen D, Bennedbaek FN, Hansen LK, Hoier-Madsen M, Jacobsen BB, Hegedus L. Thyroid function, morphology and autoimmunity in young patients with insulin-dependent diabetes mellitus. Eur J Endocrinol 1999; 140: 512-518
15. Jaeger C, Hatziagelaki E, Petzoldt R, Bretzel RC. Comparative analysis of organ-specific autoantibodies and celiac disease-associated anti bodies in type 1 diabetic patients, their first-degree relatives, and healthy control subjects. Diabetes Care 2001; 24: 27-32
16. Jun HS, Khil LY, Yoon JW. Role of glutamic acid decarboxylase in the pathogenesis of type 1 diabetes. Cell Mol Life Sci 2002a; 59: 1892-1901
17. Jun HS, Chung YH, Han J, Kim A, Yoo SS, Sherwin RS, Yoon JW. Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expressing glutamic acid decarboxylase. Diabetologia 2002b; 45: 668-676
18. Kawasaki E, Abiru N, Yano M, Uotani S, Matsumoto K, Yamasaki H, Yamamoto H, Yamaguchi Y, Akazawa S, Nagataki S. Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies. J Autoimmun 1995; 8: 633-643
19. Kim J, Namchuk M, Bugawan T, Fu Q, Jaffe M, Shi T, Aanstoot HJ, Turck CW, Erlich H, Lennon V, Baekkeskov S. Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus. J Exp Med 1994; 180: 595-606
20. Knip M, Vahasalo P, Karjalainen J, Lounamaa R, Akerblom HK. Natural history of preclinical IDDM in high risk siblings. Childhood Diabetes in Finland Study Group. Diabetologia 1994; 37: 388-393
21. Kontiainen S, Schlenzka A, Koskimies S, Rilva A, Maenpaa J. Autoantibodies and autoimmune diseases in young diabetics. Diabetes Res 1990; 13: 151-156
22. Lan MS, Wasserfall C, Maclaren NK, Notkins AL. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1996; 93: 6367-6370
23. Lernmark A. Glutamic acid decarboxylase-gene to antigen to disease. J Intern Med 1996; 240: 259-277
24. Lethagen AL, Ericsson UB, Hallengren B, Groop L, Tuomi T. Glutamic acid decarboxylase antibody positivity is associated with an impaired insulin response to glucose and arginine in nondiabetic patients with autoimmune thyroiditis. J Clin Endocrinol Metab 2002; 87: 1177-1183
25. Maclaren NK, Riley WJ. Thyroid, gastric and adrenal autoimmunities associated with insulin-dependent diabetes mellitus. Diabetes Care 1985; 8: 34-38
26. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-429
27. Maugendre D, Verite F, Guilhem I, Genetet B, Allannic H, Delamaire M. Anti-pancreatic autoimmunity and Graves' disease: study of a cohort of 600 Causacian patients. Eur J Endocrinol 1997; 137: 503-510
28. McCanlies E, O'Leary LA, Foley TP, Kramer MK, Burke JP, Libman A, Swan JS, Steenkiste AR, Mccarthy BJ, Trucco M, Dorman JS. Hashimoto's thyroiditis and insulin-dependent diabetes mellitus: differences among individuals with and without abnormal thyroid function. J Clin Endoc Metab 1998; 83: 1548-1551
29. Mochizuki M, Amemiya S, Kobayashi K, Kobayashi K, Shimura Y, Ishi-hara T, Nakagomi Y, Onigata K, Tamai S, Kasuga A, Nanazawa S. Association of the CTLA-4 49 A/G polymorphism with type 1 diabetes and autoimmune thyroid disease in Japanese children. Diabetes Care 2003; 26: 843-847
30. Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, Paquette TL. Insulin antibodies in insulin-dependent diabetics before insulin-treatment. Science 1983; 222: 1337-1339
31. Rattarasam C, Diasdado MA, Ortego J, Leelawattana R, Soonthornpun S, Setasuban W, Jaruratanasirikul S, Patarakijvanich N. Thyroid autoantibodies in Thai type 1 diabetic patients: clinical significance and their relation ship with glutamic acid decarboxylase antibodies. Diabetes Res Clin Prac 2000; 49: 107-111
32. Riley WJ, Maclaren NK, Lezotta DC, Spillar RP, Rosenbloom AL. Thyroid autoimmunity in insulin-dependent diabetes mellitus: the case for routine screening. J Pediatr 1981; 99: 350-354
33. Rolandsson O, Hagg E, Hampe C, Sullivan EP Jr, Nilsson M, Jannson G, Hallmans G, Lernmark A. Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index. Diabetologia 1999; 42: 555-559
34. Sabbah E, Savola K, Kulmala P, Reijonen H, Veijola R, Vahasalo P, Karja-lainen J, Ilonen J, Akerblom HK, Knip M. Disease-associated antibodies and HLA-DQBI genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). The Childhood Diabetes in Finland Study Group. Clin Exp Immunol 1999; 116: 78-83
35. Schmidt KD, Valeri C, Leslie RDG. Autoantibodies in type 1 diabetes. Clinica Chimica Acta 2005; 354: 35-40
36. Seino Y, Goto Y, Taminato T, Ikeda M, Imura H. Plasma insulin and glucose responses to arginine in patients with thyroid dysfunction. J Clin Endocrinol Metab 1974; 38: 1136-1140
37. Shiau MY, Tsai ST, Hwang J, Wu CY, Chang YH. Relationship between autoantibodies against glutamic acid decarboxylase, thyroglobulin/thyroid microsome and DNA topoisomerase II in the clinical manifestations of patients with type 1 diabetes mellitus in Taiwan. Eur J Endocrinol 2000; 142: 577-585
38. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N EngJ Med 1990; 322: 1555-1560
39. Srikanta S, Ganda OP, Rabizadeh A, Soeldner JS, Eisenbarth GS. First-degree relatives of patients with type 1 diabetes mellitus. Islet-cell antibodies and abnormal insulin secretion. N Eng J Med 1985; 313: 461-464
40. Thai AC, Ng WY, Lui KF, Cheah JS. Islet cell and thyroid autoimmunity in Chinese patients with IDDM. Diabetes Care 1995; 18: 586-587
41. Tremble J, Morgenthaler NG, Vlug A, Powers AC, Christie MR, Scherbaum WA, Banga JP. Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. J Clin Endocrinol Metab 1997; 82: 2664-2670
42. Tripathy D, Carlsson AL, Lehto M, Isomaa B, Tuomi T, Groop L. Insulin secretion and insulin sensitivity in diabetic subgroups: studies in pre-diabetic state. Diabetologia 2000; 43: 1476-1483
43. Vardi P, Modan-Mozes D, Ish-Shalom S, Soloveitzik L, Barzilai D, Modan M. Low titer, competitive insulin autoantibodies are spontaneously produced in autoimmune diseases of the thyroid. Diabetes Res Clin Prac 1993; 21: 161-166
44. Weetman AP, McGregor AM. Autoimmune thyroid disease: further developments in our understanding. Endocr Rev 1994; 15: 788-830