Caspase-3 and caspase-6 in ductal breast carcinoma: A descriptive study

Histology and Histopathology

Volumn 21, Issue 10-12, 2006, Pages 1321-1329

  Blazquez S ^a   Sirvent, J J ^b   Olona, M ^b   Aguilar, C ^b   Pelegri, A ^c   Garcia, J F ^b   Palacios, J ^d  

^a Hospital Sant Pau i Santa Tecla   (Spain)

^b HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^c HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

^d Structural Biology and Biocomputing Programme   (Spain)

Author keywords

Apoptosis; Breast; Cancer; Caspase 3; Caspases

Indexed keywords

CASPASE 3; CASPASE 6; CASP3 PROTEIN, HUMAN; CASP6 PROTEIN, HUMAN; CASPASE;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER MORTALITY; CANCER RECURRENCE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; NICK END LABELING; PAGET NIPPLE DISEASE; PROGNOSIS; PROTEIN EXPRESSION; TUMOR NECROSIS; TUMOR VOLUME; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; LYMPH NODE; MORTALITY; NECROSIS; PATHOLOGY; PREDICTION AND FORECASTING; RECURRENT DISEASE; SURVIVAL;

APOPTOSIS; CARCINOMA, DUCTAL, BREAST; CASPASE 3; CASPASE 6; CASPASES; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPH NODES; NECROSIS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RECURRENCE; SURVIVAL ANALYSIS;

EID: 33750298200     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Bai M., Agnantis N.J., Kamina S., Demou A., Zagorianakou P., Katsaraki A. and Kanavaros P. (1999). In vivo cell kinetics in breast carcinogenesis. Breast Cancer Res. Treat. 58, 163-169.
2. Berardo M.D., Elledge R.M., de Moor C., Clark G.M., Osborne C.K. and Allred D.C. (1998). Bcl-2 and apoptosis in lymph node positive carcinoma. Cancer 82, 1296-1302.
3. Botha J.L., Bray F., Sankila R. and Parkin D.M. (2003). Breast cancer incidence and mortality trends in 16 European countries. Eur. J. Cancer 39, 1718-1729.
4. Del Bufalo D., Biroccio A., Triscivoglio D., Bruno T., Floridi A., Aquino A. and Zupi G. (2002). Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used. Eur. J. Cancer 38, 2455-2462.
5. Elston C.W. and Ellis I.O. (1988). Classification of malignant breast disease. In: The breast. systematic pathology. 3rd ed. Elston C.W. and Ellis I.O. (eds). Churchill Livingston. Edimburgh. pp. 239-247.
6. Fernández-Alnemri T., Litwack G. and Alnmri E.S. (1995). Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res. 55, 2737-2742.
7. Fernández-Alnemri T., Takahashi A., Armstrong R., Krebs J., Fritz L., Tomaselli K.J., Wang L., Yu Z., Croce C.M. and Salveson G. (1995a). Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res. 55, 6045-6055.
8. Gilmore A.P., Metcalfe A.M., Romer L.H. and Streuli C.H. (2000). Integrin-mediated survival signals regulate the apoptotic functions of Bax through its conformation and subcellular localization. J. Cell. Biol. 149, 431-445.
9. Green D. and Kroemer G. (1998). The central executioners of apoptosis: caspases or mitochondria?. Cell Biol. 8, 267-271.
10. Hadjiloucas I., Gilmore A.P., Bundrer N.J. and Streuli C.H. (2001). Assessment of apoptosis in human breast tissue using an antibody against the active form of caspasa 3: relation to tumour histopathological characteristics. Br. J. Cancer 85, 1522-1526.
11. Jong J.S. de, Diest J. Van and Baak J.P.A. (2000). Number of apoptotic cells as a prognostic marker in invasive breast cancer. Br. J. Cancer 82, 368-377.
12. Kato T., Kamoeka S., Kimura T., Tanaka S., Nishikawa T. and Kobayashi M. (2002). p53, mitosis, apoptosis and necrosis as prognostic indicators of long-term survival in breast cancer. Anticancer Res. 22, 1105-1112.
13. Krajewska M., Wang H.G., Krajewski S., Zapata J.M., Shabaik A., Gascoyne R. and Reed J.C. (1997). Immunohistochemical anakysis of in vivo patterns of expression of CPP32 (caspase-3), a cell death protease. Cancer Res. 57, 1605-1613.
14. Lipponen P. and Aaltomaa S. (1994). Apoptosis in bladder cancer as related to standard prognostic factors and prognosis. J. Pathol. 173, 333-339.
15. Nakopoulou L., Alexandrou P., Stefanaki K., Panayotopoulou E., Lazaris A.C. and Davaris P.S. (2001). Immunohistochemical expression of caspase-3 as an adverse indicator of the clinical outcome in human breast cancer. Pathobiology 69, 266-273.
16. O'Donovan M., Crown J., Stunell H., Hill A.D.K., McDermott E., O'Higgins N. and Duffy M.J. (2003). Caspase 3 in breast cancer. Clin. Cancer Res. 9, 738-742.
17. Parkin D.M., Bray F., Ferlay J. and Pisani P. (2001). Estimating the world cancer burden: Globocan 2000. Int. J. Cancer. 94, 153-156.
18. Rich T., Allen R.L. and Wyllie A.H.(2000). Defying death after DNA damage. Nature 407, 777-783.
19. Sirvent J.J., Aguliar M.C., Clone M., Pelegrí A., Blázquez S. and Gutiérrez C. (2004). Prognosis value of apoptosis in breast cancer (pT1-pT2). A TUNEL, p53, bcl-2, bag-1 and bax immuno-histochemical study. Histol. Histopathol. 19, 759-770.
20. Tavassoli F.A. and Devilee P. (2003). Pathology and Genetics tumours of the breast cancer and female genital organs. I.A.R.C. W.H.O. Classification Tumours 4. Genova.
21. Vakkala M., Lähteenmäki K., Raunio H., Pääkkö P. and Soini Y. (1999). Apoptosis during breast carcinoma progression. Clin. Cancer Res. 5, 319-324.