Impact of ibuprofen therapy in the outcome of experimental pneumococcal acute otitis media treated with amoxicillin or erythromycin

Pediatric Research

Volumn 60, Issue 5, 2006, Pages 555-559

  Del Prado, Gema ^a   Martínez Marín, Carmina ^a   Huelves, Lorena ^a   Gracia, Matilde ^a   Rodríguez Cerrato, Violeta ^a   Fernández Roblas, Ricardo ^a   Ponte, Carmen ^a   Cenjor, Carlos ^a   Soriano, Francisco ^a  

^a Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ERYTHROMYCIN ETHYLSUCCINATE; IBUPROFEN; PENICILLIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC PROPHYLAXIS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL COUNT; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG MIXTURE; DRUG POTENCY; FEMALE; MIDDLE EAR; NONHUMAN; OTITIS MEDIA; OTORRHEA; OTOSCOPY; PRIORITY JOURNAL; THERAPY DELAY; TREATMENT OUTCOME;

AMOXICILLIN; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHILD; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ERYTHROMYCIN; FEMALE; GERBILLINAE; HUMANS; IBUPROFEN; OTITIS MEDIA; PNEUMOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; TREATMENT OUTCOME;

EID: 33750297333     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000242258.52590.b5     Document Type: Article

References (21)

1. McCaig LF, Hughes JM 1995 Trends in antimicrobial drug prescribing among office-based physicians in the United States. JAMA 273:214-219
2. Bertin L, Pons G, d'Athis P, Duhamel JF, Maudelonde C, Lasfargues G, Guillot M, Marsac A, Debregeas B, Olive G 1996 A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. Fundam Clin Pharmacol 10:387-392
3. American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media 2004 Diagnosis and management of acute otitis media. Pediatrics 113:1451-1465
4. Graham GG, Scott KF 2005 Mechanism of action of paracetamol. Am J Ther 12:46-55
5. Hersh EV, Lally ET, Moore PA 2005 Update on cyclooxygenase inhibitors: has a third COX isoform entered the fray? Curr Med Res Opin 21:1217-1226
6. Ponte C, Parra A, Cenjor C, García-Olmos M, Giménez MJ, Aguilar L, Carcas A, Soriano F 2003 Does acetaminophen interfere in the antibiotic treatment of acute otitis media caused by a penicillin-resistant pneumococcus strain? A gerbil model. Pediatr Res 54:913-918
7. National Committee for Clinical Laboratory Standards 2003 Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, Sixth Edition: Approved Standard M7-A6. Wayne, PA, National Committee for Clinical Laboratory Standards
8. National Committee for Clinical Laboratory Standards 1999 Methods for Determining Bactericidal Activity of Antimicrobial Agents, Approved guideline. Document M26-A. Wayne, PA, National Committee for Clinical Laboratory Standards
9. Eliopoulos G, Moellering R 1996 Antimicrobial combinations. In: Lorian V (ed) Antibiotics in Laboratory Medicine. Williams & Wilkins, Baltimore, pp 330-396
10. Cenjor C, Ponte C, Parra A, Nieto E, Garcia-Calvo G, Gimenez MJ, Aguilar L, Soriano F 1998 In vivo efficacies of amoxicillin and cefuroxime against penicillin-resistant Streptococcus pneumoniae in a gerbil model of acute otitis media. Antimicrob Agents Chemother 42:1361-1364
11. Parra A, Ponte C, Cenjor C, Garcia-Calvo G, Gimenez MJ, Aguilar L, Soriano F 2002 Optimal dose of amoxicillin in treatment of otitis media caused by a penicillin-resistant pneumococcus strain in the gerbil model. Antimicrob Agents Chemother 46:859-862
12. Parra A, Ponte C, Cenjor C, Martínez-Marín C, Soriano F and the Spanish Pneumococcal Infection Study Network 2004 Effect of antibiotic treatment delay on therapeutic outcome of experimental acute otitis media caused by Streptococcus pneumoniae strains with different susceptibilities to amoxicillin. Antimicrob Agents Chemother 48:860-866
13. Martinez-Marín C, Huelves L, del Prado G, García-Cía JI, Cenjor C, Ponte C, Granizo JJ, Soriano F 2005 Effect of erythromycin treatment delay on therapeutic outcome of experimental acute otitis media caused by Streptococcus pneumoniae. J Antimicrob Chemother 56:783-786
14. Jungkeit MC, Chole RA 1991 Ibuprofen inhibits localized bone resorption in the middle ear. Calcif Tissue Int 48:267-271
15. Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ 2004 Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 39:1267-1284
16. Tuomanen E, Hengstler B, Rich R, Bray MA, Zak O, Tomasz A 1987 Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis. J Infect Dis 155:985-990
17. Rinaldo JE, Pennock B 1986 Effects of ibuprofen on endotoxin-induced alveolitis: biphasic dose response and dissociation between inflammation and hypoxemia. Am J Med Sci 291:29-38
18. Nickerson SC, Paape MJ, Harmon RJ, Ziv G 1986 Mammary leukocyte response to drug therapy. J Dairy Sci 69:1733-1742
19. Little P, Gould C, Williamson I, Moore M, Warner G, Dunleavey J 2001 Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. BMJ 322:336-342
20. Handley JO Otitis media. N Engl J Med 2002;347:1169-1174
21. Van Zuijlen DA, Schilder AG, Van Balen FA, Hoes AW 2001 National differences in incidence of acute mastoiditis: relationship to prescribing patterns of antibiotics for acute otitis media? Pediatr Infect Dis J 20:140-144