Effect of erythromycin treatment delay on therapeutic outcome of experimental acute otitis media caused by Streptococcus pneumoniae

Journal of Antimicrobial Chemotherapy

Volumn 56, Issue 4, 2005, Pages 783-786

  Martínez Marín, Carmina ^a   Huelves, Lorena ^a   del Prado, Gema ^a   García Cía, José I ^a   Cenjor, Carlos ^a   Ponte, Carmen ^a   Granizo, Juan J ^a   Soriano, Francisco ^a  

^a Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

Gerbils; Otitis; Pneumococcal; Therapy delay

Indexed keywords

ERYTHROMYCIN ETHYLSUCCINATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; AREA UNDER THE CURVE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG HALF LIFE; DRUG MEGADOSE; DRUG POTENCY; ERADICATION THERAPY; GERBIL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OTITIS MEDIA; SINGLE DRUG DOSE; STREPTOCOCCUS PNEUMONIAE; TREATMENT FAILURE; TREATMENT OUTCOME; TREATMENT PLANNING;

ANIMALS; ANTI-BACTERIAL AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROMYCIN; GERBILLINAE; MICROBIAL SENSITIVITY TESTS; OTITIS MEDIA; PNEUMOCOCCAL INFECTIONS; TIME FACTORS; TREATMENT OUTCOME;

EID: 27144527297     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dki322     Document Type: Article

References (10)

1. Bluestone CD, Stephenson JS, Martín, L.M. Ten-year review of otitis media pathogens. Pediatr Infect Dis J 1992; 11 Suppl 8: 7-11.
2. Little P, Gould C, Williamson I et al. Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. Br Med J 2001; 322: 336-42.
3. Froom J, Culpepper L, Jacobs M et al. Antimicrobials for acute otitis media? A review from the International Primary Care Network. Br Med J 1997; 315: 98-102.
4. Parra A, Ponte C, Cenjor C et al. Effect of antibiotic treatment delay on the therapeutic outcome of experimental acute otitis media caused by Streptococcus pneumoniae strains with different susceptibilities to amoxicillin. Antimicrob Agents Chemother 2004; 48: 860-6.
5. Soriano F, Parra A, Cenjor C et al. Role of Streptococcus pneumoniae and Haemophilus influenzae in the development of acute otitis media with effusion in a gerbil model. J Infect Dis 2000; 181: 646-52.
6. Craig WA, Andes D. Pharmacokinetics and pharmacodynamics of antibiotics in otitis media. Pediatr Infect Dis J 1996; 15: 255-9.
7. Nelson CT, Mason EO JR, Kaplan SL. Activity of oral antibiotics in middle ear and sinus infections caused by penicillin-resistant Streptococcus pneumoniae: Implications for treatment. Pediatr Infect Dis J 1994; 13: 585-9.
8. Ginsburg CM, McCracken GH Jr, Nelson JD. Pharmacology of oral antibiotics used for treatment of otitis media and tonsillopharyngitis in infants and children. Ann Otol Rhinol Laryngol 1981; 90 Suppl: 37-43.
9. Ponte C, Parra A, Cenjor C et al. Does acetaminophen interfere in the antibiotic treatment of acute otitis media caused by a penicillin-resistant pneumococcus strain? A gerbil model. Pediatr Res 2003; 54: 913-18.
10. Hendley JO. Otitis media. N Engl J Med 2002; 347: 1169-74.