Availability and metabolism of 77Se-methylseleninic acid compared simultaneously with those of three related selenocompounds

Toxicology and Applied Pharmacology

Volumn 217, Issue 1, 2006, Pages 51-62

  Suzuki, Kazuo T ^a   Ohta, Yuki ^a   Suzuki, Noriyuki ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Absolute label; Enriched stable isotope; Metabolism; Methylseleninic acid; Methylselenonic acid; Selenate; Selenite; Selenium; Selenosugar; Speciation; Trimethylselenonium

Indexed keywords

METHYLSELENINIC ACID; METHYLSELENOL; METHYLSELENONIC ACID; RADIOISOTOPE; SELENATE; SELENITE; SELENIUM; SELENIUM 76; SELENIUM 77; SELENIUM 78; SELENIUM 82; SELENIUM DERIVATIVE; SELENOPROTEIN; UNCLASSIFIED DRUG; ISOTOPE; METHYLSELENIC ACID; ORGANOSELENIUM DERIVATIVE; SODIUM SELENITE; TRIMETHYLSELENONIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DEMETHYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY; LIVER; LUNG; MALE; MASS SPECTROMETRY; METABOLISM; METHYLATION; NONHUMAN; PANCREAS; PROTEIN SYNTHESIS; RAT; SERUM; URINE; ANIMAL; BLOOD; COMPARATIVE STUDY; DEALKYLATION; METHODOLOGY; ORAL DRUG ADMINISTRATION; TIME; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEALKYLATION; ISOTOPES; MALE; MASS SPECTROMETRY; METHYLATION; ORGANOSELENIUM COMPOUNDS; RATS; SELENIUM; SELENIUM COMPOUNDS; SODIUM SELENITE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 33750293891     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.07.005     Document Type: Article

References (31)

1. Birringer M., Pilawa S., and Flohe L. Trends in selenium biochemistry. Nat. Prod. Rep. 19 (2002) 693-718
2. Burk R.F., and Hill K.E. Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu. Rev. Nutr. 25 (2005) 11.1-11.21
3. Cho S.D., Jiang C., Malewicz B., Dong Y., Young C.Y.F., Kang K.-S., Lee Y.-S., Ip C., and Lu J. Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription. Mol. Cancer Ther. 3 (2004) 605-612
4. Combs Jr. G.F. An analysis of cancer prevention by selenium. BioFactors 14 (2001) 153-159
5. Francesconi K.A., and Pannier F. Selenium metabolites in urine: a critical overview of past work and current status. Clin. Chem. 50 (2004) 2240-2253
6. Ganther H.E. Enzymic synthesis of dimethylselenide from sodium selenite in mouse liver extracts. Biochemistry 5 (1966) 1089-1098
7. Ganther H.E. Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis 20 (1999) 1657-1666
8. Hsieh H.S., and Ganther H.E. Biosynthesis of dimethylselenide from sodium selenite in rat liver and kidney cell-free systems. Biochim. Biophys. Acta 497 (1977) 205-217
9. Hu H., Jiang C., Li G., Ip C., Rustum Y.M., and Lu J. Methylseleninic acid potentiates apoptosis induced by chemotherapeutic drugs in androgen-independent prostate cancer cells. Clin. Cancer Res. 11 (2005) 2379-2388
10. Hu H., Jiang C., Li G., and Lu J. KB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells. Carcinogenesis 26 (2005) 1374-1381
11. Ip C. Lessons from basic research in selenium and cancer prevention. J. Nutr. 128 (1998) 1845-1854
12. Ip C., Thompson H.J., Zhu Z., and Ganther H.E. In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention. Cancer Res. 60 (2000) 2882-2886
13. 82Se-enriched selenate and selenite. J. Chromatogr. B 760 (2001) 73-81
14. Kobayashi Y., Ogra Y., Ishiwata K., Takayama H., Aimi N., and Suzuki K.T. Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range. Proc. Natl. Acad. U. S. A. 99 (2002) 15932-15936
15. Lee S.O., Nadiminty N., Wu X.X., Lou W., Dong Y., Ip C., Onate S.A., and Gao A.C. Selenium disrupts estrogen signaling by altering estrogen receptor expression and ligand binding in human breast cancer cells. Cancer Res. 65 (2005) 3487-3492
16. Mozier N.M., McConnell K.P., and Hoffman J.L. S-Adenosyl-l-methioninethioether S-methyltransferase, a new enzyme in sulfur and selenium metabolism. J. Biol. Chem. 263 (1988) 4527-4531
17. Ogra Y., Hatano T., Ohmichi M., and Suzuki K.T. Oxidative production of monomethylated selenium from the major urinary selenometabolite, selenosugar. J. Anal. At. Spectrom. 18 (2003) 1252-1255
18. Ogra Y., Ishiwata K., and Suzuki K.T. Effects of deuterium in octopole reaction and collision cell ICP-MS on detection of selenium in extracellular fluids. Anal. Chim. Acta 554 (2005) 123-129
19. 82Se-enriched selenite in brain, liver, kidneys and testes. Life Sci. 67 (2000) 3041-3049
20. Spallholz J.E., Palace V.P., and Reid T.W. Methioninase and selenomethionine but not Se-methylselenocysteine generate methylselenol and superoxide in an in vitro chemiluminescent assay: implications for the nutritional carcinostatic activity of selenoamino acids. Biochem. Pharmacol. 67 (2004) 547-554
21. SPSS, 2005. SPSS 13.0 for windows. SPSS Inc., USA.
22. Suzuki K.T. Metabolomics of selenium: Se metabolites based on speciation studies. J. Health Sci. 51 (2005) 107-114
23. Suzuki K.T., and Itoh M. Metabolism of selenite labeled with enriched stable isotope in bloodstream. J. Chromatogr., B 692 (1997) 15-22
24. Suzuki K.T., Kurasaki K., Okazaki N., and Ogra Y. Selenosugar and trimethylselenonium among urinary Se metabolites: dose- and age-related changes. Toxicol. Appl. Pharmacol. 206 (2005) 1-8
25. Suzuki K.T., Kurasaki K., Ogawa K., and Suzuki N. Metabolic transformation of methylseleninic acid through key selenium intermediate selenide. Toxicol. Appl. Pharmacol. 215 (2006) 189-197
26. 76Se-selenosugar in selenium deficient rats. Toxicol. Appl. Pharmacol. doi:10.1016/j.taap.2006.05.016.
27. 77Se-selenomethionine by absolute labeling and speciation. Toxicol. Appl. Pharmacol. 217 (2006) 43-50
28. Suzuki, K.T., Somekawa, L., Kurasaki, K. Suzuki, N. in press-c. Absolute labeling and simultaneous speciation in tracer experiments with multiple stable isotopes. J. Health Sci.
29. Whanger P.D. Selenocompounds in plants and animals and their biological significance. J. Am. Coll. Nutr. 21 (2002) 223-232
30. Whanger P.D., Ip C., Polan C.E., Uden P.C., and Welbaum G. Tumorgenesis, metabolism, speciation, bioavailability, and tissue deposition of selenium in selenium-enriched ramps (Allium tricoccum). J. Agric. Food Chem. 48 (2000) 5723-5730
31. Zhao H., Whitfield M.L., Xu T., Botstein D., and Brooks J.D. Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells. Mol. Biol. Cell 15 (2004) 506-519