Radiolabeled l-Lysine for Tumor Imaging

Academic Radiology

Volumn 13, Issue 11, 2006, Pages 1327-1337

  Karacalioglu, Alper O ^a   Yang, David J ^a   Azhdarinia, Ali ^a   Mendez, Richard ^a   Oh, Changsok ^a   Kohanim, Saady ^a   Chanda, Mithu ^a   Greenwell, Allison C ^a   Yu, Dong Fang ^a   Kim, E Edmund ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

99mTc dimercaptosuccinic acid (99mTc DMSA); 99mTc dimercaptosuccinicacid l lysine (99mTc DMSA L lysine); biodistribution; imaging; l lysine

Indexed keywords

CHELATING AGENT; LYSINE; PERTECHNETIC ACID TC 99M; SUCCIMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; BREAST ADENOCARCINOMA; BREAST CANCER; CANCER CELL; CELL ASSAY; CELL COUNT; CELL CULTURE; CELL NUCLEUS MEMBRANE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CLINICAL ASSESSMENT; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; CYTOPLASM; DOSE CALCULATION; DOSIMETRY; DRUG DISTRIBUTION; DRUG UPTAKE; FEASIBILITY STUDY; FEMALE; IMAGING; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MASS SPECTROMETRY; MUSCLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PAPER CHROMATOGRAPHY; PRIORITY JOURNAL; PURIFICATION; RADIATION DOSE; RADIOASSAY; RADIOCHEMISTRY; RAT; RAT STRAIN; SCINTIGRAPHY; SYNTHESIS; THIN LAYER CHROMATOGRAPHY; TIME; TUMOR;

ADENOCARCINOMA; ANIMALS; BREAST; BREAST NEOPLASMS; CHELATING AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, PAPER; CHROMATOGRAPHY, THIN LAYER; DISEASE MODELS, ANIMAL; FEASIBILITY STUDIES; FEMALE; LYSINE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; RADIOMETRY; RADIOPHARMACEUTICALS; RATS; RATS, INBRED F344; TECHNETIUM TC 99M DIMERCAPTOSUCCINIC ACID; TUMOR CELLS, CULTURED;

EID: 33750283638     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acra.2006.03.022     Document Type: Article

References (44)

1. Laverman P., Boerman O.C., Corstens F.H., et al. Fluorinated amino acids for tumour imaging with positron emission tomography. Eur J Nucl Med Mol Imaging 29 (2002) 681-690
2. Saier Jr. M.H., Daniels G.A., Boerner P., et al. Neutral amino acid transport systems in animal cells: potential targets of oncogene action and regulators of cellular growth. J Membr Biol 104 (1988) 1-20
3. Busch H., Davis J.R., Honig G.R., et al. The uptake of a variety of amino acids into nuclear proteins of tumors and other tissues. Cancer Res 19 (1959) 1030-1039
4. Isselbacher K.J. Sugar and amino acid transport by cells in culture-differences between normal and malignant cells. N Engl J Med 286 (1972) 929-933
5. Miyagawa T., Oku T., Uehara H., et al. "Facilitated" amino acid transport is upregulated in brain tumors. J Cereb Blood Flow Metab 18 (1998) 500-509
6. Sontheimer H. Ion channels and amino acid transporters support the growth and invasion of primary brain tumors. Mol Neurobiol 29 (2004) 61-71
7. Christensen H.N. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev 70 (1990) 43-77
8. Ishiwata K., Enomoto K., Sasaki T., et al. A feasibility study on L-[1-carbon-11]tyrosine and L-[methyl-carbon-11]methionine to assess liver protein synthesis by PET. J Nucl Med 37 (1996) 279-285
9. Stryer L. Biochemistry (1995), WH Freeman, New York
10. Langen K.J. Amino acid transport studies in brain tumors. In: Feinendegen L.E., Shreeve W.W., Eckelman W.C., Bahk Y.W., and Wagner Jr. H.N. (Eds). Molecular nuclear medicine: the challenge of genomics and proteomics to clinical practice (2003), Springer-Verlag, Berlin 477-485
11. Langen K.J., Pauleit D., and Coenen H.H. 3-[(123)I]Iodo-alpha-methyl-L-tyrosine: uptake mechanisms and clinical applications. Nucl Med Biol 29 (2002) 625-631
12. Kornberg R.D. Chromatin structure: a repeating unit of histones and DNA. Science 184 (1974) 868-871
13. Luger K., Mader A.W., Richmond R.K., et al. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389 (1997) 251-260
14. Kurdistani S.K., and Grunstein M. Histone acetylation and deacetylation in yeast. Nat Rev Mol Cell Biol 4 (2003) 276-284
15. Lachner M., and Jenuwein T. The many faces of histone lysine methylation. Curr Opin Cell Biol 14 (2002) 286-298
16. Lachner M., O'Sullivan R.J., and Jenuwein T. An epigenetic road map for histone lysine methylation. J Cell Sci 116 (2003) 2117-2124
17. Zhang Y. Transcriptional regulation by histone ubiquitination and deubiquitination. Genes Dev 17 (2003) 2733-2740
18. Tordera V., Sendra R., and Perez-Ortin J.E. The role of histones and their modifications in the informative content of chromatin. Experientia 49 (1993) 780-788
19. Turner B.M. Histone acetylation and an epigenetic code. Bioessays 22 (2000) 836-845
20. Stabin M.G. MIRDOSE: personal computer software for internal dose assessment in nuclear medicine. J Nucl Med 37 (1996) 538-546
21. Deves R., and Boyd C.A. Transporters for cationic amino acids in animal cells: discovery, structure, and function. Physiol Rev 78 (1998) 487-545
22. Langen K.J., and Broer S. Molecular transport mechanisms of radiolabeled amino acids for PET and SPECT. J Nucl Med 45 (2004) 1435-1436
23. Shotwell M.A., Kilberg M.S., and Oxender D.L. The regulation of neutral amino acid transport in mammalian cells. Biochim Biophys Acta 737 (1983) 267-284
24. Souba W.W., and Pacitti A.J. How amino acids get into cells: mechanisms, models, menus, and mediators. JPEN J Parenter Enteral Nutr 16 (1992) 569-578
25. Closs E.I., and Mann G.E. Membrane transport of L-arginine and cationic amino acids analogs. In: Ignarro L.J. (Ed). Nitric oxide: biology and pathobiology (2000), Academic Press, San Diego 225-241
26. White M.F., and Christensen H.N. The two-way flux of cationic amino acids across the plasma membrane of mammalian cells is largely explained by a single transport system. J Biol Chem 257 (1982) 10069-10080
27. White M.F., and Christensen H.N. Cationic amino acid transport into cultured animal cells. II. Transport system barely perceptible in ordinary hepatocytes, but active in hepatoma cell lines. J Biol Chem 257 (1982) 4450-4457
28. Closs E.I. Expression, regulation and function of carrier proteins for cationic amino acids. Curr Opin Nephrol Hypertens 11 (2002) 99-107
29. Sperandeo M.P., Borsani G., Incerti B., et al. The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome. Genomics 49 (1998) 230-236
30. Anderson J.O., and Dobson D.C. Amino acid requirements of the chick: effect of total essential amino acid level in the diet on the arinine and lysine requirements. Poultry Sci 38 (1959) 1140-1147
31. Rolleman E.J., Valkema R., de Jong M., et al. Safe and effective inhibition of renal uptake of radiolabelled octreotide by a combination of lysine and arginine. Eur J Nucl Med Mol Imaging 30 (2003) 9-15
32. Oxender D.L., and Christensen H.N. Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell. J Biol Chem 238 (1963) 3686-3699
33. Hubner K.F., Purvis J.T., Mahaley Jr. S.M., et al. Brain tumor imaging by positron emission computed tomography using 11C-labeled amino acids. J Comput Assist Tomogr 6 (1982) 544-550
34. Jager P.L., Vaalburg W., Pruim J., et al. Radiolabeled amino acids: basic aspects and clinical applications in oncology. J Nucl Med 42 (2001) 432-445
35. Vaalburg W., Coenen H.H., Crouzel C., et al. Amino acids for the measurement of protein synthesis in vivo by PET. Int J Rad Appl Instrum B 19 (1992) 227-237
36. Ogawa T., Shishido F., Kanno I., et al. Cerebral glioma: evaluation with methionine PET. Radiology 186 (1993) 45-53
37. Tsukada H., Sato K., Fukumoto D., et al. Evaluation of D-isomers of O-11C-methyl tyrosine and O-18F-fluoromethyl tyrosine as tumor-imaging agents in tumor-bearing mice: comparison with L- and D-11C-methionine. J Nucl Med 47 (2006) 679-688
38. Hain S.F., and Beggs A.D. C-11 methionine uptake in granulomatous disease. Clin Nucl Med 29 (2004) 585-586
39. Hamill T.G., Krause S., Ryan C., et al. Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers. Synapse 56 (2005) 205-216
40. Studenov A.R., Szalda D.E., et al. Synthesis of no-carrier-added C-11 labeled D- and L-enantiomers of phenylalanine and tyrosine for comparative PET Studies. Nucl Med Biol 30 (2003) 39-44
41. Jager P.L., Franssen E.J., Kool W., et al. Feasibility of tumor imaging using L-3-[iodine-123]-iodo-alpha-methyl-tyrosine in extracranial tumors. J Nucl Med 39 (1998) 1736-1743
42. Kubota K., Matsuzawa T., Fujiwara T., et al. Differential diagnosis of AH109A tumor and inflammation by radioscintigraphy with L-[methyl-11C]methionine. Jpn J Cancer Res 80 (1989) 778-782
43. Kubota R., Kubota K., Yamada S., et al. Methionine uptake by tumor tissue: a microautoradiographic comparison with FDG. J Nucl Med 36 (1995) 484-492
44. Kuwert T., Morgenroth C., Woesler B., et al. Uptake of iodine-123-alpha-methyl tyrosine by gliomas and non-neoplastic brain lesions. Eur J Nucl Med 23 (1996) 1345-1353