HIV in pregnancy: Evolution of clinical practice in the UK

International Journal of STD and AIDS

Volumn 17, Issue 10, 2006, Pages 660-667

  Foster, C J ^a   Lyall, E G H ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Antiretroviral therapy; HIV; Mother to child transmission; Perinatal

Indexed keywords

ANTIRETROVIRUS AGENT; LAMIVUDINE; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE;

ARTIFICIAL MILK; BREAST FEEDING; CD4 LYMPHOCYTE COUNT; CESAREAN SECTION; CLINICAL PRACTICE; CLINICAL TRIAL; DELIVERY; DRUG HYPERSENSITIVITY; GLUCOSE INTOLERANCE; HEPATITIS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PREECLAMPSIA; PREGNANCY; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; PREMATURITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; RISK FACTOR; UNITED KINGDOM; VERTICAL TRANSMISSION; VIRUS LOAD; VIRUS TRANSMISSION;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BREAST FEEDING; CD4 LYMPHOCYTE COUNT; CESAREAN SECTION; CLINICAL TRIALS; DELIVERY, OBSTETRIC; DISEASE TRANSMISSION, VERTICAL; FEMALE; GREAT BRITAIN; HIV INFECTIONS; HIV-1; HUMANS; OBSTETRIC LABOR, PREMATURE; PRACTICE GUIDELINES; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; VIRAL LOAD;

EID: 33750269931     PISSN: 09564624     EISSN: 09564624     Source Type: Journal    
DOI: 10.1258/095646206780070983     Document Type: Review

References (36)

1. Health Protection Agency (HPA). Focus on Prevention. HIV and other sexually transmitted infections in the UK in 2003. An Update. November 2004 [www.hpa.org.uk]
2. The International Perinatal HIV Group. Mode of delivery and vertical transmission of HIV-1: A meta-analysis from fifteen prospective cohort studies. N Engl J Med 1999;340:977-87
3. The European Mode of Delivery Collaboration. Elective caesarean section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trial. Lancet 1999;353:1035-9
4. The International Perinatal HIV Group. Duration of ruptured membranes and vertical transmission of HIV-1: a meta-analysis from fifteen prospective cohort studies. AIDS 2001;15:357-68
5. Garcia PM, Kalish LA, Pitt J, et al. Viral load and risk of transmission. N Engl J Med 1999;341:394-402
6. Ioannidis JP, Abrams EJ, Ammann AJ, et al. Perinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads o1000 copies/ml. J Infect Dis 2001;183:539-45
7. ACOG Committee opinion. Scheduled caesarean delivery and the prevention of vertical transmission of HIV infection. Number 234, May 2000. Int J Gynaecol Obstet 2001;73:279-81
8. European Collaborative Study. Mother-to-Child transmission of HIV infection in the era of Highly Active Antiretroviral Therapy. Clin Infect Dis 2005;40:458-65
9. British HIV Association (BHIVA). Guidelines for the Management of HIV Infection in Pregnant Women and the Prevention of Mother-to-Child Transmission [www.bhiva.org.uk, 2005]
10. Connor EM, Sperling RS, Gelber R, et al. Paediatric AIDS Clinical Trial Group Protocol 076 Study Group. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N Engl J Med 1994;331:1173-80
11. Guay LA, Musoke P, Fleming T, et al. Intrapartum and neonatal single dose nevirapine compared with zidovudine for the prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet 1999;354:795-802
12. Johnson JA, Li JF, Morris L, et al. Emergence of drug-resistant HIV-1 after intrapartum administration of single-dose nevirapine is substantially underestimated. J Infect Dis 2005;192:16-23
13. Hammer SM. The more you look the more you find. J Infect Dis 2005;192:1-3
14. Flys T, Nissley DV, Claasen CW, et al. Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012. J Infect Dis 2005;192:4-29
15. Jourdian G, Ngo-Giang-Huong N, Le Coeur S, et al., Perinatal HIV Prevention Trial Group. Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy. N Engl J Med 2004;351:229-40
16. Moodley D, Moodley J, Coovadia H, et al. South African Intrapartum Nevirapine Trial (SAINT) Investigators. A multicenter randomized controlled trial of nevirapine versus a combination of zidovudine and lamivudine to reduce intrapartum and early postpartum mother-to-child transmission of human immunodeficiency virus type 1. J Infect Dis 2003;187:725-35
17. Muro E, Droste JA, Hofstede HT, Bosch M, Dolmans W, Burger DM. Nevirapine plasma concentrations are still detectable after more than 2 weeks in the majority of women receiving single-dose nevirapine: implications for intervention studies. J Acquir Immune Defic Syndr 2005;39:419-21
18. Larbalestier N, Mullen J, O'Shea S, et al. Drug resistance is uncommon in pregnant women with low viral loads taking zidovudine monotherapy to prevent perinatal HIV transmission. AIDS 2003;17:2665-7
19. Baylor M, Truffa M, Gibbs N. Hepatic toxicity of antiretrovirals in HIV-infected pregnant women: a review of the FDA's adverse event reporting system. 11th Conference on Retroviruses and Opportunistic Infections. San Francisco, Feb, 2004;944
20. Hitti J, Frenkel LM, Stek AM, et al. Maternal toxicity with continuous nevirapine therapy in pregnancy: results from PACTG 1022. J Acquir Immune Defic Syndr 2004;36:772-6
21. Lyons F, Coughlan S, Byrne C, et al. Emergence of genotypic resistance in HIV positive women receiving combination antiretroviral therapy in pregnancy. AIDS 2005;19:63-7
22. Beitune PE, Duarte G, Foss MC, et al. Effects of antiretroviral agents on carbohydrate metabolism in HIV-1 infected pregnant women. Diabetes Metab Res Rev 2006;22:59-63
23. Cohan D, Feakins C, Wara D, et al. Perinatal transmission of multi-drug resistant HIV-1 despite viral suppression on an enfuvirtide based regimen. AIDS 2005;19:989-90
24. Suy A, Coll O, Martinez E, et al. Increased risk of pre-eclampsia and foetal death in HIV-infected pregnant women receiving highly active antiretroviral therapy. XV International AIDS Conference. Bangkok, 2004, Abs ThOrB1359
25. Wimalasundera RC, Larbalestier N, Smith JH, et al. Pre-eclampsia, antiretroviral therapy and immune reconstitution. Lancet 2002;360:1152-4
26. The European Collaborative Study and the Swiss Mother and Child HIV Cohort Study. Combination antiretroviral therapy and duration of pregnancy. AIDS 2000;14:2913-20
27. Tuomala RE, Shapiro DE, Mofenson LM, et al. Antiretroviral therapy during pregnancy and the risk of an adverse outcome. N Engl J Med 2002;346:1863-70
28. Noguera A, Fortuny C, Munoz-Almagro C, et al. Hyperlactatemia in human immunodeficiency virus-infected infants who are exposed to antiretrovirals. Paediatrics 2004;114:598-603
29. Blanche S, Tardieu M, Rustin P, et al. Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues. Lancet 1999;354:1084-9
30. The Perinatal Safety Review Working Group. Nucleoside exposure in the children of HIV infected women receiving antiretroviral drugs: absence of clear evidence for mitochondrial disease in children who died before 5 years of age in five United States Cohorts. J Acquir Immune Defic Syndr 2000;25:261-8
31. Divi RL, Walker VE, Wade NA, et al. Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir. AIDS 2004;18:1013-21
32. Le Chenadec J, Mayaux MJ, Guihenneuc-Jouyaux C, Blanche S, Enquete Perinatale Francaise Study Group. Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants. AIDS 2003;17:2053-61
33. Ayers KM, Clive D, Tucker Jr WE, Hajian G, de Miranda P. Nonclinical toxicology studies with zidovudine: genetic toxicity tests and carcinogenicity bioassays in rats and mice. Fundam Appl Toxicol 1996;32:148-58
34. Nduati R, John G, Ngacha DA, et al. Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomised clinical trial. JAMA 2000;283:1167-74
35. Gaillard P, Fowler M, Dabis F, et al. Use of antiretroviral drugs to prevent HIV-1 transmission through breastfeeding: from animal studies to randomized clinical trials. J Acquir Immune Defic Syndr 2004;35:178-87
36. Shapiro RL, Holland DT, Capparelli E, et al. Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment. J Infect Dis 2005;192:720-7