Prion protein allele A136H154Q171 is associated with high susceptibility to scrapie in purebred and crossbred German Merinoland sheep

Archives of Virology

Volumn 149, Issue 8, 2004, Pages 1571-1580

  Luhken G ^a   Buschmann, A ^b   Groschup, M H ^b   Erhardt, G ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL; ARTICLE; BREEDING; CODON; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; GENOTYPE; GERMANY; HAPLOTYPE; PRION; SCRAPIE; SHEEP;

ALLELES; ANIMALS; BREEDING; CODON; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GERMANY; HAPLOTYPES; PRIONS; SCRAPIE; SHEEP; VARIATION (GENETICS);

OVIS ARIES;

EID: 4043163375     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Baylis M, Houston H, Goldmann W, Hunter N, McLean AR (2000) The signature of scrapie: differences in the PrP genotype profile of scrapie-affected and scrapie-free UK sheep flocks. Proc Roy Soc London 267: 2029-2035
2. Benestad SL, Sarradin P, Thu B, Schönheit J, Tranulis MA, Bratberg B (2003) Cases of scrapie with unusual features in Norway and designation of a new type, Nor98. Vet Rec 153: 202-208
3. Bossers A, Schreuder BE, Muileman IH, Belt PB, Smits MA (1996) PrP genotype contributes to determining survival times of sheep with natural scrapie. J Gen Virol 77: 2669-2673
4. Buschmann A, Biacabe A, Ziegler U, Bencsik A, Madec J-Y, Erhardt G, Lühken G, Baron T, Groschup MH (2003) Atypical scrapie cases in Germany and France are revealed by non-uniform rapid test reaction patterns. J Virol Methods, in press
5. Dawson M, Hoinville LJ, Hosie BD, Hunter N (1998) Guidance on the use of PrP genotyping as an aid to the control of clinical scrapie. Vet Rec 142: 623-625
6. Dubois M-A, Sabatier P, Durand B, Calavas D, Ducrot C, Chalvet-Monfray K (2002) Multiplicative genetic effects in scrapie disease susceptibility. C R Biologies 325: 565-570
7. Elsen J-M, Amigues Y, Schelcher F, Ducrocq V, Andreoletti O, Eychenne F, Tien Khang JV, Poivey J-P, Lantier F, Laplanche J-L (1999) Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov. Arch Virol 144: 431-445
8. Haliassos A, Chomel JC, Tesson L, Baudis M, Kruh J, Kaplan JC, Kitzis A (1989) Modification of enzymatically amplified DNA for the detection of point mutations. Nucleic Acids Res 17: 3606
9. Hunter N (1997) PrP genetics in sheep and the implications for scrapie and BSE. Trends Microbiol 5: 331-334
10. Hunter N, Foster JD, Goldmann W, Stear MJ, Hope J, Bostock C (1996) Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes. Arch Virol 141: 809-824
11. Hunter N, Goldmann W, Benson G, Foster JD, Hope J (1993) Swaledale sheep affected by natural scrapie differ significantly in PrP genotype frequencies from healthy sheep and those selected for reduced incidence of scrapie. J Gen Virol 74: 1025-1031
12. Hunter N, Goldmann W, Foster JD, Cairns D, Smith G (1997) Natural scrapie and PrP genotype: case-control studies in British sheep. Vet Rec 141: 137-140
13. Hunter N, Moore L, Hosie B, Dingwall W, Greig A (1997) Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland. Vet Rec 140: 59-63
14. Junghans F, Teufel B, Buschmann A, Steng G, Groschup MH (1998) Genotyping of German sheep with respect to scrapie susceptibility. Vet Rec 143: 340-341
15. Kutzer T, Pfeiffer I, Brenig B (2002) Identification of new allelic variants in the ovine prion protein (PrP) gene. J Anim Breed Genet 119: 201-208
16. Lee IY, Westaway D, Smit AFA, Wang K, Seto J, Chen L, Acharya C, Ankener M, Baskin D, Cooper C, Yao H, Prusiner SB, Hood LE (1998) Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res 8: 1022-1037
17. O'Doherty E, Healy A, Aherne M, Hanrahan JP, Weavers E, Doherty M, Roche JF, Gunn M, Sweeney T (2002) Prion protein (PrP) gene polymorphisms associated with natural scrapie cases and their flock-mates in Ireland. Res Vet Sci 73: 243-250
18. Report of the Government of the Federal Republic of Germany to the European Commision on the survey of prion protein genotypes of sheep breeds in Germany, demanded by the Commission Decision 2003/1003/EC of 18 December 2002 laying down minimum requirements for a survey of prion protein genotypes of sheep breeds, document number C(2002) 5102. Off J L 349, 24/12/2002, 105-107
19. Thorgeirsdottir S, Sigurdarson S, Thorisson HM, Georgsson G, Palsdottir A (1999) PrP gene polymorphism and natural scrapie in Icelandic sheep. J Virol 80: 2527-2534
20. Tranulis MA (2002) Influence of the prion protein gene, Prnp, on scrapie susceptibility in sheep. APMIS 110: 33-43
21. Yuzbasiyan-Gurkan V, Krehbiel JD, Cao Y, Venta PJ (1999) Development and usefulness of new polymerase chain reaction-based tests for detection of different alleles at codons 136 and 171 of the ovine prion protein gene. Am J Vet Res 60: 884-887
22. Zsolnai A, Anton I, Kühn C, Fésüs L (2003) Detection of single-nucleotide polymorphisms coding for three ovine prion protein variants by primer extension assay and capillary electrophoresis. Electrophoresis 24: 634-638