Short mucin 6 alleles are associated with H pylori infection

World Journal of Gastroenterology

Volumn 12, Issue 37, 2006, Pages 6021-6025

  Nguyen, Thai V ^a   Janssen, Marcel J R ^b   Gritters, Paulien ^b   te Morsche, René H M ^b   Drenth, Joost P H ^b   van Asten, Henri ^b   Laheij, Robert J F ^b   Jansen, Jan B M J ^b  

^a CAN THO UNIVERSITY OF MEDICINE AND PHARMACY   (Viet Nam)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

H pylori; Mucin 6; Polymorphism; Variable number of tandem repeats

Indexed keywords

DNA FRAGMENT; MUCIN 6;

ADULT; ALLELE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DNA DETERMINATION; DNA ISOLATION; FEMALE; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL INFECTION; GENETIC ASSOCIATION; GENETIC CODE; GENOTYPE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT CODING; RESTRICTION MAPPING; SOUTHERN BLOTTING; UPPER GASTROINTESTINAL TRACT; UREA BREATH TEST; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 33750251839     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i37.6021     Document Type: Article

References (20)

1. Kuipers EJ. Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther 1997; 11 Suppl 1: 71-88
2. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, Taniyama K, Sasaki N, Schlemper RJ. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001; 345: 784-789
3. Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev 2000; 22: 283-297
4. Ota H, Nakayama J, Momose M, Hayama M, Akamatsu T, Katsuyama T, Graham DY, Genta RM. Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins. Virchows Arch 1998; 433: 419-426
5. Van Klinken BJ, Dekker J, Buller HA, de Bolos C, Einerhand AW. Biosynthesis of mucins (MUC2-6) along the longitudinal axis of the human gastrointestinal tract. Am J Physiol 1997; 273: G296-G302
6. Vinall LE, Hill AS, Pigny P, Pratt WS, Toribara N, Gum JR, Kim YS, Porchet N, Aubert JP, Swallow DM. Variable number tandem repeat polymorphism of the mucin genes located in the complex on 11p15.5. Hum Genet 1998; 102: 357-366
7. Debailleul V, Laine A, Huet G, Mathon P, d'Hooghe MC, Aubert JP, Porchet N. Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs. J Biol Chem 1998; 273: 881-890
8. Corfield AP, Myerscough N, Longman R, Sylvester P, Arul S, Pignatelli M. Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut 2000; 47: 589-594
9. Vinall LE, King M, Novelli M, Green CA, Daniels G, Hilkens J, Sarner M, Swallow DM. Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis. Gastroenterology 2002; 123: 41-49
10. Garcia E, Carvalho F, Amorim A, David L. MUC6 gene polymorphism in healthy individuals and in gastric cancer patients from northern Portugal. Cancer Epidemiol, Biomarkers Prev 1997; 6: 1071-1074
11. Carvalho F, Seruca R, David L, Amorim A, Seixas M, Bennett E, Clausen H, Sobrinho-Simoes M. MUC1 gene polymorphism and gastric cancer-an epidemiological study. Glycoconj J 1997; 14: 107-111
12. Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, Gum JR Jr, Byrd JC, Siddiki B, Kim YS. Human gastric mucin. Identification of a unique species by expression cloning. J Biol Chem 1993; 268: 5879-5885
13. Hegedus O, Ryden J, Rehnberg AS, Nilsson S, Hellstrom PM. Validated accuracy of a novel urea breath test for rapid Helicobacter pylori detection and in-office analysis. Eur J Gastroenterol Hepatol 2002; 14: 513-520
14. Dekker J, Rossen JW, Buller HA, Einerhand AW. The MUC family: an obituary. Trends Biochem Sci 2002; 27: 126-131
15. Van den Brink GR, Tytgat KM, Van der Hulst RW, Van der Loos CM, Einerhand AW, Buller HA, Dekker J. H pylori colocalises with MUC5AC in the human stomach. Gut 2000; 46: 601-607
16. Van de Bovenkamp JH, Mahdavi J, Korteland-Van Male AM, Buller HA, Einerhand AW, Boren T, Dekker J. The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. Helicobacter 2003; 8: 521-532
17. Ho SB, Takamura K, Anway R, Shekels LL, Toribara NW, Ota H. The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins. Dig Dis Sci 2004; 49: 1598-1506
18. Ilver D, Arnqvist A, Ogren J, Frick IM, Kersulyte D, Incecik ET, Berg DE, Covacci A, Engstrand L, Boren T. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science 1998; 279: 373-377
19. Nordman H, Davies JR, Lindell G, de Bolos C, Real F, Carlstedt I. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. Biochem J 2002; 364: 191-200
20. Kawakubo M, Ito Y, Okimura Y, Kobayashi M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T, Nakayama J. Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection. Science 2004; 305: 1003-1006