Expression of the RERG gene is gender-dependent in hepatocellular carcinoma and regulated by histone deacetyltransferases

Journal of Korean Medical Science

Volumn 21, Issue 5, 2006, Pages 891-896

  Wang, Ai Guo ^a   Fang, Wan ^a   Han, Ying Hao ^a   Cho, Sang Mi ^a   Choi, Jong Young ^b   Lee, Kee Ho ^c   Kim, Wook Hwan ^d   Kim, Jin Man ^e   Park, Moon Gi ^f   Yu, Dae Yeul ^a   Kim, Nam Soon ^a   Lee, Dong Seok ^a,g  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Korea Institute of Radiation and Medical Science   (South Korea)

^d Ajou University School of Medicine   (South Korea)

^e Chungnam National University   (South Korea)

^f Sun General Hospital   (South Korea)

^g Kangwon National University   (South Korea)

Author keywords

Carcinoma, hepatocellular; Histone acetyltransferases; Ras related estrogen regulated and growth inhibitory gene (RERG); Sex

Indexed keywords

EID: 33750235877     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2006.21.5.891     Document Type: Article

References (23)

1. Finlin BS, Gau CL, Murphy GA, Shao H, Kimel T, Seitz RS, Chiu YF, Botstein D, Brown PO, Der CJ, Tamanoi F, Andres DA, Perou CM. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. J Biol Chem 2001; 276: 42259-67.
2. Joo M, Chi JG, Lee H. Expressions of HSP70 and HSP27 in hepatocellular carcinoma. J Korean Med Sci 2005; 20: 829-34.
3. Kim YS, Um SH, Ryu HS, Lee JB, Lee JW, Park DK, Kim YS, Jin YT, Chun HJ, Lee HS, Lee SW, Choi JH, Kim CD, Hyun JH. The prognosis of liver cirrhosis in recent years in Korea. J Korean Med Sci 2003; 18: 833-41.
4. Tanaka K, Sakai H, Hashizume M, Hirohata T. Serum testosterone: estradiol ratio and the development of hepatocellular carcinoma among male cirrhotic patients. Cancer Res 2000; 60: 5106-10.
5. Firminger HI, Reuber MD. Influence of adrenocortical, androgenic, and anabolic hormones on the development of carcinoma and cirrhosis of the liver in A x C rats fed N-2-fluorenyldicetamide. J Natl Cancer Inst 1961; 27: 559-95.
6. Kemp CJ, Leary CN, Drinkwater NR. Promotion of murine hepatocarcinogenesis by testosterone is androgen receptor-dependent but not cell autonomous. Proc Natl Acad Sci USA 1989; 86: 7505-9.
7. Okuda K. Hepatocellular carcinoma. J Hepatol 2000; 32: 225-37.
8. Gray SG, Teh BT. Histone acetylation/deacetylation and cancer: an "open" and "shut" case? Curr Mol Med 2001; 1: 401-29.
9. Gui CY, Ngo L, Xu WS, Richon VM, Marks PA. Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1. Proc Natl Acad Sci USA 2004; 101: 1241-6.
10. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 2003; 370 (Pt 3): 737-49.
11. Greene AK, Puder M. Partial hepatectomy in the mouse: technique and perioperative management. J Invest Surg 2003; 16: 99-102.
12. Villa E, Camellini L, Dugani A, Zucchi F, Grottola A, Merighi A, Buttafoco P, Losi L, Manenti F. Variant estrogen receptor messenger RNA species detected in human primary hepatocellular carcinoma. Cancer Res 1995; 55: 498-500.
13. Villa E, Grottola A, Colantoni A, De Maria N, Buttafoco P, Ferretti I, Manenti F. Hepatocellular carcinoma: role of estrogen receptors in the liver. Ann N Y Acad Sci 2002; 963: 37-45.
14. Wang AG, Moon HB, Lee MR, Hwang CY, Kwon KS, Yu SL, Kim YS, Kim M, Kim JM, Kim SK, Lee TH, Moon EY, Lee DS, Yu DY. Gender-dependent hepatic alterations in H-ras12V transgenic mice. J Hepatol 2005; 43: 836-44.
15. Alao JP, Lam EW, Ali S, Buluwela L, Bordogna W, Lockey P, Varshochi R, Stavropoulou AV, Coombes RC, Vigushin DM. Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. Clin Cancer Res 2004; 10: 8094-104.
16. Herold C, Ganslmayer M, Ocker M, Hermann M, Geerts A, Hahn EG, Schuppan D. The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. J Hepatol 2002; 36: 233-40.
17. Johnson PJ. Sex hormones and the liver. Clin Sci (Lond) 1984; 66: 369-76.
18. Eagon PK, Porter LE, Francavilla A, DiLeo A, Van Thiel DH. Estrogen and androgen receptors in liver: their role in liver disease and regeneration. Semin Liver Dis 1985; 5: 59-69.
19. Roy AK, Milin BS, McMinn DM. Androgen receptor in rat liver: hormonal and developmental regulation of the cytoplasmic receptor and its correlation with the androgen-dependent synthesis of alpha 2u-globulin. Biochim Biophys Acta 1974; 354: 213-32.
20. Sato N, Ota M, Obara K. Presence of binding component(s) for testosterone in rat liver cytosol. Endocrinol Jpn 1980; 27: 315-9.
21. Nagasue N, Ito A, Yukaya H, Ogawa Y. Androgen receptors in hepatocellular carcinoma and surrounding parenchyma. Gastroenterology 1985; 89: 643-7.
22. Porter LE, Elm MS, Van Thiel DH, Dugas MC, Eagon PK. Characterization and quantitation of human hepatic estrogen receptor. Gastroenterology 1983; 84: 704-12.
23. Rossini GP, Baldini GM, Villa E, Manenti F. Characterization of estrogen receptor from human liver. Gastroenterology 1989; 96: 1102-9.