Postchallenge glucose rises with increasing age even when glucose tolerance is normal

Diabetic Medicine

Volumn 23, Issue 11, 2006, Pages 1174-1179

  Rhee, M K ^a   Ziemer, D C ^a   Kolm, P ^b   Phillips, L S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Ageing; Glucose intolerance; Postchallenge glucose

Indexed keywords

GLUCOSE;

ADULT; AGED; AGING; ARTICLE; DIABETES MELLITUS; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; HUMAN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; ORAL GLUCOSE TOLERANCE TEST; PROVOCATION TEST; SEX DIFFERENCE;

ADOLESCENT; ADULT; AGE FACTORS; AGED; BLOOD GLUCOSE; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS; FEMALE; GLUCOSE INTOLERANCE; HUMANS; INFANT; MALE; MIDDLE AGED; RISK FACTORS; TIME FACTORS;

EID: 33750150521     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2006.01956.x     Document Type: Article

References (45)

1. Nathan DM. Long term complications of diabetes mellitus. N Engl J Med 1993; 328: 1676-1685.
2. 1999 Diabetes Surveillance Report. Washington, DC: U.S. Department of Health and Human Services. Available at http://www.cdc.gov/diabetes/statistics/ survl99/index.htm 2005. Last accessed 3 March 2005.
3. National Diabetes Fact Sheet: General Information and National Estimates on Diabetes in the United States, 2003. Washington, DC: U.S. Department of Health and Human Services. Centers for Disease Control and Prevention 2004. Available at http://www.cdc.gov/diabetes/pubs/factsheet.htm. Last accessed 30 October 2005.
4. U.S. Renal Data System, USRDS 2004 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health. National Institute of Diabetes and Digestive and Kidney Diseases 2004. Available at http://www.usrds.org/atlas.htm. Last accessed 30 October 2005.
5. Klein R, Klein BEK, Moss SE, Davis MD, DeMets DL, The Wisconsin Epidemiologic Study of Diabetic Retinopathy III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more yearS. Arch Ophthalmol 1984; 102: 527-532.
6. Tominaga M, Eguchi H, Manaka H, Igarashi K, Kato T, Sekikawa A. Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care 1999; 22: 920-924.
7. de Vegt F, Dekker JM, Ruhe HG, Stehouwer CD, Nijpels G, Bouter LM et al. Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study. Diabetologia 1999; 42: 926-931.
8. The DECODE Study Group. Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria. Arch Intern Med 2001; 161: 397-405.
9. Smith NL, Barzilay JI, Shaffer D, Savage PJ, Heckbert SR, Kuller LH et al. Fasting and 2-hour postchallenge serum glucose measures and risk of incident cardiovascular events in the elderly: the Cardiovascular Health Study. Arch Intern Med 2002; 162: 209-216.
10. Jackson RA. Mechanisms of age-related glucose tolerance. Diabetes Care 1990; 13: 9-19.
11. Jackson RA, Blix PM, Matthews JA, Hamling JB, Din BM, Brown DC et al. Influence of ageing on glucose homeostasis. J Clin Endocrinol Metab 1982; 55: 840-848.
12. Maneatis T, Condie R, Reaven G. Effect of age on plasma glucose and insulin responses to a test mixed meal. J Am Geriatr Soc 1982; 30: 178-182.
13. Rosenthal M, Doberne L, Greenfield M, Widstrom A, Reaven GM. Effect of age on glucose tolerance, insulin secretion, and in vivo insulin action. J Am Geriatr Soc 1982; 30: 562-567.
14. Zavaroni I, Dall'Aglio E, Bruschi F, Bonora E, Alpi O, Pezzarossa A et al. Effect of age and environmental factors on glucose tolerance and insulin secretion in a worker population. J Am Geriatr Soc 1986; 34: 271-275.
15. Jackson RA, Hawa MI, Roshania RD, Sim BM, DiSilvio L, Jaspan JB. Influence of aging on hepatic and peripheral glucose metabolism in humans. Diabetes 1988; 37: 119-129.
16. Shimokata H, Muller DC, Fleg JL, Sorkin J, Ziemba AW, Andres R. Age as independent determinant of glucose tolerance. Diabetes 1991; 40: 44-51.
17. Resnick HE, Harris MI, Brock DB, Harris TB. American Diabetes Association diabetes diagnostic criteria, advancing age, and cardiovascular disease risk profiles: results from the Third National Health and Nutrition Examination Survey. Diabetes Care 2000; 23: 176-180.
18. Reaven G. Age and glucose intolerance: effect of fitness and fatness. Diabetes Care 2003; 26: 539-540.
19. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2005; 28: S37-S42.
20. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15: 539-553.
21. Cleveland WS, Gross E, Shyu WM. Local regression models. In: Chambers JM, Hastie TJ eds. Statistical Models in S. California: Pacific Grove. Wadsworth & Brooks/Cole 1992: 309-376.
22. van Buuren S, Oudshoorn CGM. Multivariate Imputation by Chained Equations. MICE V1.0 User's Manual. Leiden, The Netherlands: Netherlands Organisation for Applied Scientific Research (TNO) 2000.
23. Rowe JW, Minaker KL, Pallotta JA, Flier JS. Characterization of the insulin resistance of aging. J Clin Invest 1983; 71: 1581-1587.
24. Chen M, Bergman RN, Pacini G, Porte D Jr. Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function. J Clin Endocrinol Metab 1985; 60: 13-20.
25. Wang JT, Ho LT, Tang KT, Wang LM, Chen YD, Reaven GM. Effect of habitual physical activity on age-related glucose intolerance. J Am Geriatr Soc 1989; 37: 203-209.
26. Coon PJ, Rogus EM, Drinkwater D, Muller DC, Goldberg AP. Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age. J Clin Endocrinol Metab 1992; 75: 1125-1132.
27. Kohrt WM, Kirwan JP, Staten MA, Bourey RE, King DS, Holloszy JO. Insulin resistance in aging is related to abdominal obesity. Diabetes 1993; 42: 273-281.
28. Cefalu WT, Wang ZQ, Werbel S, Bell-Farrow A, Crouse JR 3rd, Hinson WH et al. Contribution of visceral fat mass to the insulin resistance of aging. Metabolism 1995; 44: 954-959.
29. Iozzo P, Beck-Nielsen H, Laakso M, Smith U, Yki-Jarvinen H, Ferrannini E. Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance. J Clin Endocrinol Metab 1999; 84: 863-868.
30. Imbeault P, Prins JB, Stolic M, Russell AW, O'Moore-Sullivan T, Despres JP et al. Aging per se does not influence glucose homeostasis: in vivo and in vitro evidence. Diabetes Care 2003; 26: 480-484.
31. Seals DR, Hagberg JM, Allen WK, Hurley BF, Dalsky GP, Ehsani AA et al. Glucose tolerance in young and older athletes and sedentary men. J Appl Physiol 1984; 56: 1521-1525.
32. Pacini G, Valerio A, Beccaro F, Nosadini R, Cobelli C, Crepaldi G. Insulin sensitivity and beta-cell responsivity are not decreased in elderly subjects with normal OGTT. J Am Geriatr Soc 1988; 36: 317-323.
33. American Diabetes Association. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20: 1183-1197.
34. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005; 365: 1415-1428.
35. Ferrannini E, Vichi S, Beck-Nielsen H, Laakso M, Paolisso G, Smith U. Insulin action and age. European Group for the Study of Insulin Resistance (EGIR). Diabetes 1996; 45: 947-953.
36. Tuomilehto J. Point: a glucose tolerance test is important for clinical practice. Diabetes Care 2002; 25: 1880-1882.
37. Sasso FC, Carbonara O, Nasti R, Campana B, Marfella R, Torella M et al. Glucose metabolism and coronary heart disease in patients with normal glucose tolerance. JAMA 2004; 291: 1857-1863.
38. Liu K, Dyer AR, Vu TH, Pirzada A, Manheim LM, Manning WG et al. One-hour postload plasma glucose in middle age and medicare expenditures in older age among nondiabetic men and women: the Chicago Heart Association Detection Project in Industry. Diabetes Care 2005; 28: 1057-1062.
39. Washburn RA, Adams LL, Haile GT. Physical activity assessment for epidemiologic research: the utility of two simplified approaches. Prev Med 1987; 16: 636-646.
40. Goodpaster BH, Krishnaswami S, Resnick H, Kelley DE, Haggerty C, Harris TB et al. Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care 2003; 26: 372-379.
41. Gastaldelli A, Miyazaki Y, Pettiti M, Matsuda M, Mahankali S, Santini E et al. Metabolic effects of visceral fat accumulation in type 2 diabetes. J Clin Endocrinol Metab 2002; 87: 5098-5103.
42. Despres JP, Nadeau A, Tremblay A, Ferland M, Moorjani S, Lupien PJ et al. Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes 1989; 38: 304-309.
43. The DECODE Study Group. Age, body mass index and glucose tolerance in 11 European population-based surveys. Diabet Med 2002; 19: 558-565.
44. Wang Y, Rimm EB, Stampfer MJ, Willett WC, Hu FB. Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr 2005; 81: 555-563.
45. Wolever TM, Chiasson JL, Csima A, Hunt JA, Palmason C, Ross SA et al. Variation of postprandial plasma glucose, palatability, and symptoms associated with a standardized mixed test meal versus 75 g oral glucose. Diabetes Care 1998; 21: 336-340.