The SAMP8 mouse as a model for Alzheimer disease: Studies from Saint Louis University

International Congress Series

Volumn 1260, Issue C, 2004, Pages 23-28

  Morley, J E ^a,b   Banks, W A ^a,b   Kumar, V B ^a,b   Farr, S A ^a,b  

^a SAINT LOUIS UNIVERSITY   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antisense; Beta Amyloid; Memory; Retention

Indexed keywords

EID: 33750137858     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0531-5131(03)01562-0     Document Type: Article

References (31)

1. J.F. Flood J.E. Morley Age related impairment of aversive and appetitive learning in the SAMP P/8 mouse strain. A model of dementia of early onset J. Gerontol. Biol. Sci. 47 1992 B52 B59
2. J.F. Flood J.E. Morley Age-related changes in footshock avoidance acquisition and retention in senescence accelerated mouse (SAM0 Neurobiol. Aging 14 1993 153 157
3. J.F. Flood S.A. Farr F.E. Kaiser J.E. Morley Age-related impairment in learning but not memory in SAMP8 female mice Pharmacol. Biochem. Behav. 50 1995 661 664
4. J.F. Flood J.E. Morley Learning and memory in the SAMP8 mouse Neurosci. Biobehav. Rev. 22 1998 1 20
5. S.A. Farr W.A. Banks M.E. La Scola J.F. Flood J.E. Moley Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention Brain Res. 872 2000 242 249
6. J.F. Flood F.J. Harris J.E. Morley Age-related changes in hippocampal drug facilitation of memory processing in SAMP8 mice Neurobiol. Aging 17 1996 15 24
7. J.F. Flood S.A. Farr K. Uezu J.E. Morley Age-related changes in septal serotonergic, GABAergic and glutamatergic facilitation of retention in SAMP8 mice Mech. Ageing Dev. 105 1998 173 188
8. J.F. Flood J.E. Morley M. La Reginna Age-related changes in the pharmacological improvement of retention in senescence accelerated mouse (SAM) Neurobiol. Aging 14 1993 159 166
9. L.B. Jaeger S.A. Farr W.A. Banks J.E. Morley Effects of orexin-A on memory processing Peptides 23 2002 1683 1688
10. J.F. Flood J.E. Morley E. Roberts An amyloid beta-protein fragment, A beta [12–28], equipotently impairs post-training memory processing when injected into different limbic system structures Brain Res. 663 1994 271 276
11. J.F. Flood J.E. Morley E. Roberts An amyloid-β fragment A β [12–28] equipotently impairs post-training memory processing when injected into different limbic system structures Brain Res. 663 1994 271 276
12. J.F. Flood E. Roberts M.A. Sherman B.E. Kaplan J.E. Morley Topography of a binding site for small amnestic peptides deduced from structure–activity studies: relation to amnestic effect of amyloid beta protein Proc. Natl. Acad. Sci. U. S. A. 91 1994 380 384
13. J.E. Morley V.B. Kumar A.E. Bernardo S.A. Farr K. Uezu N. Tumosa J.F. Flood Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memory Peptides 21 2000 1761 1767
14. J.E. Morley S.A. Farr J.F. Flood Antibody to amyloid beta protein alleviates impaired acquisition, retention, and memory processing in SAMP8 mice Neurobiol. Learn. Mem. 78 2002 125 138
15. S.A. Farr W.A. Banks K. Uezu A. Sano F.S. Gaskin J.E. Morley Antibody to beta-amyloid protein increases acetylcholine in the hippocampus of 12 month SAMP8 male mice Life Sci. 73 2003 555 562
16. V.B. Kumar K. Vyas M. Franko V. Choudhary C. Buddhiraju J. Alvarez J.E. Morley Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8) Biochem. Cell. Biol. 79 2001 57 67
17. V.B. Kumar S.A. Farr J.F. Flood V. Kamlesh M. Franko W.A. Banks J.E. Morley Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice Peptides 21 2000 1769 1775
18. W.A. Banks S.A. Farr W. Butt V.B. Kumar M.W. Franko J.E. Morley Delivery across the blood–brain barrier of antisense directed against amyloid beta: reversal of learning and memory deficits in mice overexpressing amyloid precursor protein J. Pharmacol. Exp. Ther. 297 2001 1113 1121
19. W.A. Banks S.A. Farr M.E. La Scola J.E. Morley Intravenous human interleukin-1 alpha impairs memory processing in mice: dependence on blood–brain barrier transport into posterior division of the septum J. Pharmacol. Exp. Ther. 299 2001 536 541
20. A. Moinuddin J.E. Morley W.A. Banks Regional variations in the transport of interleukin-1 alpha across the blood–brain barrier in ICR and aging SAMP8 mice Neuroimmunomodulation 8 2000 165 170
21. H. Xaio W.A. Banks M.L. Niehoff J.E. Morley Effect of LPS on the permeability of the blood–brain barrier to insulin Brain Res. 896 2001 36 42
22. W.A. Banks A. Moinuddin J.E. Morley Regional transport of TNF-alpha across the blood–brain barrier in young ICR and young and aged SAMP8 mice Neurobiol. Aging 22 2001 671 676
23. W.A. Banks S.A. Farr J.E. Morley Permeability of the blood–brain barrier to albumin and insulin in the young and aged SAMP8 mouse J. Gerontol. Biol. Sci. 55A 2000 B601 B606
24. S.A. Farr H.F. Poon D. Dogrukol-Ak J. Drake W.A. Banks E. Eyerman D.A. Butterfield J.E. Morley The antioxidants alpha-lipoic acid and N -acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice J. Neurochem. 84 2003 1173 1183
25. J.F. Flood S.A. Farr F.E. Kaiser M. La Regina J.E. Morley Age-related decrease of plasma testosterone in SAMP8 mice: replacement improves age-related impairment of learning and memory Physiol. Behav. 57 1995 669 673
26. H.J. Armbrecht M.A. Boltz V.B. Kumar J.F. Flood J.E. Morley Effect of age on calcium-dependent proteins in hippocampus of senescence-accelerated mice Brain Res. 842 1999 287 293
27. J.F. Flood P.M. Morley J.E. Morley Age-related changes in learning, memory, and lipofuscin as a function of the percentage of SAMP8 genes Physiol. Behav. 58 1995 819 822
28. V.B. Kumar M.W. Franko S.A. Farr H.J. Armbrecht J.E. Morley Identification of age-dependent changes in expression of senescence-accelerate mouse (SAMP8) hippocampal proteins by expression array analysis Biochem. Biophys. Res. Commun. 272 2000 657 661
29. J.E. Morley The SAMP8 mouse: a model of Alzheimer disease? Biogerontology 3 1–2 2002 57 60
30. J.E. Morley S.A. Farr V.B. Kumar W.A. Banks Alzheimer's disease through the eye of a mouse. Acceptance lecture for the 2001 Gayle A. Olson and Richard D. Olson Prize Peptides 23 2002 589 599
31. R. Strong V. Reddy J.E. Morley Cholinergic deficits in the septal-hippocampal pathway of the SAM-P/8 senescence accelerated mouse Brain Res. 966 2003 156 160