Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na+ and Ca2+ and PKA-independent increase of cytosolic Ca2+ associated with insulin secretion in hamster pancreatic β-cells

Toxicology and Applied Pharmacology

Volumn 216, Issue 3, 2006, Pages 363-372

  Miura, Yoshikazu ^a   Matsui, Hisao ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Cytosolic Na+; Incretin; Insulin secretion; Protein kinase A; Triphenyltin chloride

Indexed keywords

ADENYLATE CYCLASE; BENZOFURAN DERIVATIVE; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXCHANGE PROTEIN DIRECTLY ACTIVATED CYCLIC AMP; FORSKOLIN; FURA 2; GLUCAGON LIKE PEPTIDE 1; INSULIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHTHALIC ACID DERIVATIVE; PROTEIN; SODIUM ION; TRIPHENYLTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HAMSTER; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; STATISTICAL SIGNIFICANCE;

ANIMALS; BUCLADESINE; CALCIUM; CRICETINAE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSOL; ENVIRONMENTAL POLLUTANTS; FORSKOLIN; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON-LIKE PEPTIDE 1; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MESOCRICETUS; ORGANOTIN COMPOUNDS; SODIUM;

CRICETINAE;

EID: 33750090742     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.05.017     Document Type: Article

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