Tissue transglutaminase crosslinks ataxin-1: Possible role in SCA1 pathogenesis

Neuroscience Letters

Volumn 409, Issue 1, 2006, Pages 5-9

  D'Souza, D R ^a   Wei, J ^a   Shao, Q ^a   Hebert, M D ^a   Subramony, S H ^a   Vig, P J S ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Ataxin 1; Cerebellum; Degeneration; Transglutaminase

Indexed keywords

ATAXIN 1; CYSTAMINE; GLUTAMINE; GREEN FLUORESCENT PROTEIN; MUTANT PROTEIN; NUCLEAR PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL LYSATE; CELL NUCLEUS; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HELA CELL; INTRACELLULAR TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PURKINJE CELL; SPINOCEREBELLAR DEGENERATION; TRANSGENIC MOUSE;

ANIMALS; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CEREBELLUM; CYSTEAMINE; GENETIC LINKAGE; GTP-BINDING PROTEINS; HELA CELLS; HETEROZYGOTE; HUMANS; LINKAGE (GENETICS); MICE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; SPINOCEREBELLAR ATAXIAS; TRANSGLUTAMINASES;

EID: 33750089734     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.08.003     Document Type: Article

References (26)

1. Aeschlimann D., and Tomazy V. Protein crosslinking in assembly and remodeling of extracellular matrices: the role of transglutaminases. Connect. Tissue Res. 41 (2000) 1-27
2. Bailey C.D., Tucholski J., and Johnson G.V. Transglutaminases in neurodegenerative disorders. Prog. Exp. Tumor Res. 38 (2005) 139-157
3. Burright E.N., Clark H.B., Servadio A., Matilla T., Feddersen R.M., Yunis W.S., Duvick L.A., Zoghbi H.Y., and Orr H.T. SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat. Cell 82 (1995) 937-948
4. Gatchel J.R., and Zoghbi H.Y. Diseases of unstable repeat expansion: mechanisms and common principles. Nat. Rev. Genet. 6 (2005) 743-755
5. Gentile V., Sepe C., Calvani M., Melone M.A., Cotrufo R., Cooper A.J., Blass J.P., and Peluso G. Tissue transglutaminase-catalyzed formation of high-molecular-weight aggregates in vitro is favored with long polyglutamine domains: a possible mechanism contributing to CAG-triplet diseases. Arch. Biochem. Biophys. 352 (1998) 314-321
6. Hazeki N., Tukamoto T., Goto J., and Kanazawa I. Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates. Biochem. Biophys. Res. Commun. 277 (2000) 386-393
7. Howell J.L., and Truant R. Live-cell nucleocytoplasmic protein shuttle assay utilizing laser confocal microscopy and FRAP. Biotechniques 32 (2002) 80-87
8. Irwin S., Vandelft M., Pinchev D., Howell J.L., Graczyk J., Orr H.T., and Truant R. RNA association and nucleocytoplasmic shuttling by ataxin-1. J. Cell Sci. 118 (2005) 233-242
9. Iuchi S., Hoffner G., Verbeke P., Djian P., and Green N. Oligomeric and polymeric aggregates formed by proteins containing expanded polyglutamine. PNAS 100 (2003) 2409-2414
10. Junn E., Ronchetti R.D., Quezado M.M., Kim S.Y., and Mouradian M.M. Tissue transglutaminase-induced aggregation of α-synuclein: implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies. PNAS 100 (2003) 2047-2052
11. Karpuj M.V., Garren H., Slunt H., Price D.L., Gusella J., Becher M.W., and Steinman L. Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei. PNAS 96 (1999) 7388-7393
12. Kim S.Y., Grant P., Lee J.H., Pant H.C., and Steinert P.M. Differential expression of multiple transglutaminases in human brain. Increased expression and cross-linking by transglutaminases 1 and 2 in Alzheimer's disease. J. Biol. Chem. 274 (1999) 30715-30721
13. Kim S., Nollen E.A., Kitagawa K., Bindokas V.P., and Morimoto R.I. Polyglutamine protein aggregates are dynamic. Nat. Cell Biol. 4 (2002) 826-831
14. Lesort M., Attanavanich K., Zhang J., and Johnson G.V. Distinct nuclear localization and activity of tissue transglutaminase. J. Biol. Chem. 273 (1998) 11991-11994
15. Lesort M., Chun W., Johnson G.V., and Ferrante R.J. Tissue transglutaminase is increased in Huntington's disease brain. J. Neurochem. 73 (1999) 2018-2027
16. Maggio N., Sellitti S., Capano C.P., and Papa M. Tissue-transglutaminase in rat and human brain: light and electron immunocytochemical analysis and in situ hybridization study. Brain Res. Bull. 56 (2001) 173-182
17. Perutz M.F., Johnson T., Suzuki M., and Finch J.T. Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. PNAS 91 (1994) 5355-5358
18. Perez M.K., Paulson H.L., Pendse S.J., Saionz S.J., Bonini N.M., and Pittman R.N. Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation. J. Cell Biol. 143 (1998) 1457-1470
19. Preisinger E., Jordan B.M., Kazantsev A., and Housman D. Evidence for a recruitment and sequestration mechanism in Huntington's disease. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 354 (1999) 1029-1034
20. Serra H.G., Byam C.E., Lande J.D., Tousey S.K., Zoghbi H.Y., and Orr H.T. Gene profiling links SCA1 pathophysiology to glutamate signaling in Purkinje cells of transgenic mice. Hum. Mol. Genet. 13 (2004) 2535-2543
21. Sharma D., Sharma S., Pasha S., and Brahmachari S.K. Peptide models for inherited neurodegenerative disorders: conformation and aggregation properties of long polyglutamine peptides with and without interruptions. FEBS Lett. 456 (1999) 181-185
22. Takeuchi Y., Ohashi H., Birckbichler P.J., and Ikejima T. Nuclear translocation of tissue type transglutaminase during sphingosine-induced cell death: a novel aspect of the enzyme with DNA hydrolytic activity. Z. Naturforsch [C] 53 (1998) 352-358
23. Vig P.J.S., Subramony S.H., Burright E.N., Fratkin J.D., McDaniel D.O., Desaiah D., and Qin Z. Reduced immunoreactivity to calcium-binding proteins in Purkinje cells precedes onset of ataxia in spinocerebellar ataxia-1. Neurology 50 (1998) 106-113
24. Vig P.J.S., Subramony S.H., Qin Z., McDaniel D.O., and Fratkin J. Relationship between ataxin-1 nuclear inclusions and Purkinje cell specific proteins in SCA-1 transgenic mice. J. Neurol. Sci. 174 (2000) 100-110
25. Xu H., Somers Z.B., Robinson II M.L., and Hebert M.D. Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis. BMC Cell Biol. 6 (2005) 29
26. Zainelli G.M., Dudek N.L., Ross C.A., Kim S.Y., and Muma N.A. Mutant huntingtin protein: a substrate for transglutaminase 1, 2, and 3. J. Neuropathol. Exp. Neurol. 64 (2005) 58-65