Multicentre, parallel group, randomised, single-blind study of the safety and efficacy of atosiban versus ritodrine in the treatment of acute preterm labour in Korean women

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 113, Issue 11, 2006, Pages 1228-1234

  Shim, J Y ^a   Park, Y W ^b   Yoon, B H ^c   Cho, Y K ^d   Yang, J H ^e   Lee, Y ^f   Kim, A ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d Inje University College of Medicine   (South Korea)

^e Sungkyunkwan University School of Medicine   (South Korea)

^f The Catholic University of Korea   (South Korea)

Author keywords

Atosiban; Preterm labour; Ritodrine

Indexed keywords

ATOSIBAN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; LAVOPA; RITODRINE; UTERUS SPASMOLYTIC AGENT;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BRAIN HEMORRHAGE; CHEST TIGHTNESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; DYSPNEA; FEMALE; HEADACHE; HEART INFARCTION; HEART PALPITATION; HOT FLUSH; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOKALEMIA; HYPOTENSION; LUNG EDEMA; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NAUSEA; NERVOUSNESS; NEWBORN INFECTION; NEWBORN MORBIDITY; PATENT DUCTUS ARTERIOSUS; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS; SEIZURE; SIDE EFFECT; SINGLE BLIND PROCEDURE; SOUTH KOREA; TACHYCARDIA; TOCOLYSIS; TREMOR; UTERINE CERVIX DILATATION; VOMITING;

ACUTE DISEASE; ADULT; FEMALE; GESTATIONAL AGE; HUMANS; MATERNAL AGE; OBSTETRIC LABOR, PREMATURE; PREGNANCY; RITODRINE; SINGLE-BLIND METHOD; TOCOLYTIC AGENTS; TREATMENT OUTCOME; VASOTOCIN;

EID: 33750070936     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2006.01053.x     Document Type: Article

References (19)

1. Slattery MM, Morrison JJ. Preterm delivery. Lancet 2002;360:1489-97.
2. Demissie K, Rhoads GG, Ananth CV, Alexander GR, Kramer MS, Kogan MD, et al. Trends in preterm birth and neonatal mortality among blacks and whites in the United States from 1989 to 1997. Am J Epidemiol 2001;154:307-15.
3. King JF, Grant A, Keirse MJ, Chalmers I. Beta-mimetics in preterm labour: an overview of the randomized controlled trials. Br J Obstet Gynaecol 1988;95:211-22.
4. The Canadian Preterm Labor Investigators Group. Treatment of preterm labor with the beta-adrenergic agonist ritodrine. N Engl J Med 1992;327:308-12.
5. Hadi HA, Albazzaz SJ. Cardiac isoenzymes and electrocardiographic changes during ritodrine tocolysis. Am J Obstet Gynecol 1989;161:318-21.
6. Lamont RF. The pathophysiology of pulmonary oedema with the use of beta-agonists. Br J Obstet Gynaecol 2000;107:439-44.
7. Hudgens DR, Conradi SE. Sudden death associated with terbutaline sulfate administration. Am J Obstet Gynecol 1993;169:120-1.
8. Fuchs AR, Fuchs F, Husslein P, Soloff MS, Fernstrom MJ. Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor. Science 1982;215:1396-8.
9. Fuchs AR, Fuchs F, Husslein P, Soloff MS. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol 1984;150:734-41.
10. Bossmar T, Akerlund M, Fantoni G, Szamatowicz J, Melin P, Maggi M. Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy: effects of the oxytocin antagonist atosiban. Am J Obstet Gynecol 1994;171:1634-42.
11. Kinsler VA, Thornton S, Ashford ML, Melin P, Smith SK. The effect of the oxytocin antagonists F314 and F792 on the in vitro contractility of human myometrium. Br J Obstet Gynaecol 1996;103:373-5.
12. Engstrom T, Bratholm P, Vilhardt H, Christensen NJ. Effect of oxytocin receptor and beta2-adrenoceptor blockade on myometrial oxytocin receptors in parturient rats. Biol Reprod 1999;60:322-9.
13. Moutquin JM, Sherman D, Cohen H, Mohide PT, Hochner-Celnikier D, Fejgin M, et al. Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study. Am J Obstet Gynecol 2000;182:1191-9.
14. European Atosiban Study Group. The oxytocin antagonist atosiban versus the beta-agonist terbutaline in the treatment of preterm labor. A randomized, double-blind, controlled study. Acta Obstet Gynecol Scand 2001;80:413-22.
15. French/Australian Atosiban Investigators Group. Treatment of preterm labor with the oxytocin antagonist atosiban: a double-blind, randomized, controlled comparison with salbutamol. Eur J Obstet Gynecol Reprod Biol 2001;98:177-85.
16. Worldwide Atosiban versus Beta-agonists Study Group. Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. BJOG 2001;108:133-42.
17. Braden GL, von Oeyen PT, Germain MJ, Watson DJ, Haag BL. Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. Kidney Int 1997;51:1867-75.
18. Valenzuela GJ, Craig J, Bernhardt MD, Holland ML. Placental passage of the oxytocin antagonist atosiban. Am J Obstet Gynecol 1995;172:1304-6.
19. Gyetvai K, Hannah ME, Hodnett ED, Ohlsson A. Tocolytics for preterm labor: a systematic review. Obstet Gynecol 1999;94:869-77.