The role of calcium and magnesium ions in uptake of β-amyloid peptides by microglial cells

International Journal of Immunopathology and Pharmacology

Volumn 19, Issue 3, 2006, Pages 683-696

  Choucair, N ^a   Laporte, V ^b   Levy, R ^a   Tranchant, C ^a   Gies, J P ^a   Poindron, P ^a   Lombard, Y ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b ROSKAMP INSTITUTE   (United States)

Author keywords

Alzheimer's disease; Amyloid beta protein; Calcium and magnesium; LRP; Phagocytosis; Senile plaque

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); AMYLOID BETA PROTEIN[25-35]; CALCIUM ION; EDETIC ACID; EGTAZIC ACID; MAGNESIUM ION; THAPSIGARGIN;

ARTICLE; CELL CULTURE; CHELATION; ENDOPLASMIC RETICULUM; MICROGLIA; PHAGOCYTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; YEAST CELL;

EID: 33750067073     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200601900324     Document Type: Article

References (42)

1. Wisniewski H.M., A.W. Vorbrodt, J. Wegiel, J. Morys and A.S. Lossinsky. 1990. Ultrastructure of the cells forming amyloid fibers in Alzheimer disease and scrapie. Am. J. Med. Genet. 7(S):287.
2. Bamberger M.E. and G.E. Landreth. 2002. Inflammation, apoptosis, and Alzheimer's disease. Neuroscientist. 8:276.
3. Ard M.D., G.M. Cole, J. Wei, A.P. Mehrle and J.D. Fratkin. 1996. Scavenging of Alzheimer's amyloid beta-protein by microglia in culture. J. Neurosci. Res. 43:190.
4. Shaffer L.M., M.D. Dority, R. Gupta-Bansal, R.C. Frederickson, S.G. Younkin and K.R. Brunden. 1995. Amyloid beta protein (A beta) removal by neuroglial cells in culture. Neurobiol. Aging 16:737.
5. Kopec K.K. and R.T. Carroll. 1998. Alzheimer's beta-amyloid peptide 1-42 induces a phagocytic response in murine microglia. J. Neurochem. 71:2123.
6. Szczepanik A.M., D. Rampe and G.E. Ringheim. 2001. Amyloid-beta peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo. J. Neurochem. 77:304.
7. Kingham P.J. and J.M. Pocock. 2001. Microglial secreted cathepsin B induces neuronal apoptosis. J. Neurochem. 76:1475.
8. Weldon D.T., S.D. Rogers, J.R. Ghilardi, M.P. Finke, J.P. Cleary, E. O'Hare, W.P. Esler, J.E. Maggio and P.W. Mantyh. 1998. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J. Neurosci. 18:2161.
9. Smith M.E., K. Van der Maesen, F.P. Somera and R.A. Sobel. 1998. Effects of phorbol myristate acetate (PMA) on functions of macrophages and microglia in vitro. Neurochem. Res. 23:427.
10. Laporte V., Y. Lombard, R. Levy-Benezra, C. Tranchant, P. Poindron and J.M. Warter. 2004. Uptake of Abeta 1-40- and Abeta 1-42-coated yeast by microglial cells: a role for LRP. J. Leukoc. Biol. 76:451.
11. Arelin K., A. Kinoshita, C.M. Whelan, M.C. Irizarry, G.W. Rebeck, D.K. Strickland and B.T. Hyman. 2002. LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes. Brain Res. Mol. Brain Res. 104:38.
12. Krieger M. and J. Herz. 1994. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu. Rev. Biochem. 63:601.
13. Laporte V., R. Levy-Benezra, Y. Lombard, N. Choucair, C. Tranchant, J.P. Gies and P. Poindron. 2005. Characterization of a long-term cultured cell line of murine microglia called MAMI. Biovalley Monographs 1:14.
14. Giaimis J., Y. Lombard, P. Fonteneau, C.D. Muller, R. Levy, M. Makaya-Kumba, J. Lazdins and P. Poindron. 1993. Both mannose and beta-glucan receptors are involved in phagocytosis of unopsonized, heat-killed Saccharomyces cerevisiae by murine macrophages. J. Leukoc. Biol. 54:564.
15. Dolmer K., W. Huang and P.G. Gettins. 1998. Characterization of the calcium site in two complement-like domains from the low-density lipoprotein receptor-related protein (LRP) and comparison with a repeat from the low-density lipoprotein receptor. Biochemistry 37:17016.
16. Simonovic M., K. Dolmer, W. Huang, D.K. Strickland, K. Volz and P.G. Gettins. 2001. Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor. Biochemistry 40:15127.
17. Suo Z., C. Fang, F. Crawford and M. Mullan. 1997. Superoxide free radical and intracellular calcium mediate A beta (1-42) induced endothelial toxicity. Brain Res. 762:144.
18. Arora P.D., M. Glogauer, A. Kapus, D.J. Kwiatkowski and C.A. McCulloch. 2004. Gelsolin mediates collagen phagocytosis through a rac-dependent step. Mol. Biol. Cell 15:588.
19. Ohsawa K., Y. Imai, Y. Sasaki and S. Kohsaka. 2004. Microglia/macrophage- specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity. J. Neurochem. 88:844.
20. Tejle K., K.E. Magnusson and B. Rasmusson. 2002. Phagocytosis and phagosome maturation are regulated by calcium in J774 macrophages interacting with unopsonized prey. Biosci. Rep. 22:529.
21. Dewitt S., I. Laffafian and M.B. Hallett. 2003. Phagosomal oxidative activity during beta2 integral (CR3)-mediated phagocytosis by neutrophils is triggered by a non-restricted Ca2+ signal: Ca2+ controls time not space. J. Cell Sci. 116:2857.
22. Brzyska M. and D. Elbaum. 2003. Dysregulation of calcium in Alzheimer's disease. Acta Neurobiol. Exp. 63:171.
23. Mattson M.P. and S.L. Chan. 2001. Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits. J. Mol. Neurosci. 17:205.
24. Veinbergs I., A. Everson, Y. Sagar and E. Masliah. 2002. Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis. J. Neurosci. Res. 67:379.
25. Lin H., R. Bhatia and R. Lal. 2001. Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology. Faseb J. 15:2433.
26. Palotas A., J. Kalman, G. Laskay, A. Juhasz, Z. Janka and B. Penke. 2001. Comparative studies on [Ca2+]i-level of fibroblasts from Alzheimer patients and control individuals. Neurochem. Res. 26:817.
27. Lombard Y., J. Bartholeyns, M. Chokri, D. Illinger, D. Hartmann, S. Dumont, S.H. Kaufmann, R. Landmann, F. Loor and P. Poindron. 1988. Establishment and characterization of long-term cultured cell lines of murine resident macrophages. J. Leukoc. Biol. 44:391.
28. Hewlett L.J., A.R. Prescott and C. Watts. 1994. The coated pit and macropinocytic pathways serve distinct endosome populations. J. Cell. Biol. 124:689.
29. Marzol M.P., R. Von Bernhardi, G. Bu and N.C. Inestrosa. 2000. Expression of alpha (2)-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells. J. Neurosci. Res. 60:401.
30. Kang D.E., C.U. Pietrzik, L. Baum, N. Chevallier, D.E. Merriam, M.Z. Kounnas, S.L. Wagner, J.C. Troncoso, C.H. Kawas, R. Katzman and E.H. Koo. 2000. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J. Clin. Invest. 106:1159.
31. Ferreiro E., C.R. Oliveira and C. Pereira. 2004. Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide. J. Neurosci. Res. 76:872.
32. Young J.D., S.S. Ko and Z.A. Cohn. 1984. The increase in intracellular free calcium associated with IgG gamma 2b/gamma 1 Fc receptor-ligand interactions: role in phagocytosis. Proc. Natl. Acad. Sci. USA 81:5430.
33. Kobayashi K., K. Takahashi and S. Nagasawa. 1995. The role of tyrosine phosphorylation and Ca2+ accumulation in Fc gamma-receptor-mediated phagocytosis of human neutrophils. J. Biochem. 117:1156.
34. Della Bianca V., M. Grzeskowiak and F. Rossi. 1990. Studies on molecular regulation of phagocytosis and activation of the NADPH oxidase in neutrophils. IgG- and C3b-mediated ingestion and associated respiratory burst independent of phospholipid turnover and Ca2+ transients. J. Immunol. 144:1411.
35. Bengtsson T., M.E. Jaconi, M. Gustafson, K.E. Magnusson, J.M. Theler, D.P. Lew and O. Stendahl. 1993. Actin dynamics in human neutrophils during adhesion and phagocytosis is controlled by changes in intracellular free calcium. Eur. J. Cell Biol. 62:49.
36. Jaconi M.E., D.P. Lew, J.L. Carpentier, K.E. Magnusson, M. Sjogren and O. Stendahl. 1990. Cytosolic free calcium elevation mediates the phagosome-lysosome fusion during phagocytosis in human neutrophils. J. Cell. Biol. 110:1555.
37. P.D. Lew. 1985. Cytosolic free calcium, a key second messenger in cellular activation. Eur. J. Clin. Invest. 15:238.
38. Greenberg S., J. el Khoury, F. Di Virgilio, E.M. Kaplan and S.C. Silverstein. 1991. Ca(2+)-independent F-actin assembly and disassembly during Fc receptor-mediated phagocytosis in mouse macrophages. J. Cell. Biol. 113:757.
39. Zimmerli S., M. Majeed, M. Gustavsson, O. Stendahl, D.A. Sanan and J.D. Ernst. 1996. Phagosome-lysosome fusion is a calcium-independent event in macrophages. J. Cell. Biol. 132:49.
40. Edberg J.C., C.T. Lin, D. Lau, J.C. Unkeless and R.P. Kimberly. 1995. The Ca2+ dependence of human Fc gamma receptor-initiated phagocytosis. J. Biol. Chem. 270:22301.
41. Harris H.E. and A.G. Weeds. 1984. Plasma gelsolin caps and severs actin filaments. FEBS Lett. 177:184.
42. Yin H.L., J.H. Albrecht and A. Fattoum. 1981. Identification of gelsolin, a Ca2+-dependent regulatory protein of actin gel-sol transformation, and its intracellular distribution in a variety of cells and tissues. J. Cell. Biol. 91:901.