Effect of beta-amyloid peptides on alpha-7 nicotinic receptor status in astrocytes and neurons, and its relationship to pathogenesis of Alzheimer's disease

Chinese Journal of Pathology

Volumn 35, Issue 8, 2006, Pages 462-466

  Xiao, Yan ^b   Shan, Ke Ren ^b   Guan, Zhi Zhong ^a  

^a GUIZHOU MEDICAL UNIVERSITY   (China)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Alzheimer's disease; Amyloid beta protein; Astrocytes; Neurons

Indexed keywords

ALPHA 7 NICOTINIC RECEPTOR; AMYLOID BETA PROTEIN[25-35]; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL CULTURE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ASTROCYTES; BRAIN; CELL LINE, TUMOR; CELLS, CULTURED; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MICE; MUTATION; NEURONS; PEPTIDE FRAGMENTS; RECEPTORS, NICOTINIC;

EID: 33750062906     PISSN: 05295807     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev, 2001, 81:741-766.
2. Braak H, Break E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl), 1991, 82:239-259.
3. Nordberg A. Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications. Biol Psychiatry, 2001, 49:200-210.
4. Guan ZZ, Miao H, Tian JY, et al. Suppressed expression of nicotinic acetylcholine receptors by nanomolar beta-amyloid peptides in PC12 cells. J Neural Transm, 2001, 108:1417-1433.
5. Paterson D, Nordberg A. Neuronal nicotinic receptors in the human brain. Prog Neurobiol, 2000, 61:75-111.
6. Guan ZZ, Zhang X, Ravid R, et al. Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease. J Neurochem, 2000, 74:237-243.
7. Burghaus L, Schutz U, Krempel U, et al. Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients. Brain Res Mol Brain Res, 2000, 76:385-388.
8. Martin-Ruiz CM, Court JA, Molnar E, et al. Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease. J Neurochem, 1999, 73: 1635-1640.
9. Yu WF, Guan ZZ, Bogdanovic N, et al. High selective expression of alpha7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670/671 mutation: a possible association with neuritic plaques. Exp Neurol, 2005, 192:215-225.
10. Dineley KT, Westerman M, Bui D, et al. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci, 2001, 21:4125-4133.
11. Unger C, Svedberg MM, Yu WF, et al. Effect of subchronic treatment of memantine, galantamine, and nicotine in the brain of Tg2576 (APPswe) transgenic mice. J Pharmacol Exp Ther, 2006, 317:30-36.
12. Xiu J, Nordberg A, Zhang JT, et al. Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the alpha7, alpha4 and beta2 subunits in response to nanomolar concentrations of the beta-amyloid peptide (1-42). Neurochem Int, 2005, 47:281-290.