Sustained contraction and loss of NO production in TGFβ 1- treated endothelial cells

British Journal of Pharmacology

Volumn 149, Issue 4, 2006, Pages 355-364

  Watanabe, M ^a   Oike, M ^a   Ohta, Y ^a   Nawata, H ^a   Ito, Y ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Contraction; Endothelium; Nitric oxide; Smooth muscle; TGF 1

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATE; CALCIUM ION; DIAMINOFLUORESCEIN 2; DYE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUORESCEIN; FURA 2; MARKER; MARKER PROTEIN; MYOSIN LIGHT CHAIN; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PROTEIN; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; BLOOD VESSEL WALL; CELL DIFFERENTIATION; CELL FUNCTION; CELL TRANSDIFFERENTIATION; CELL TRANSFORMATION; CONTROLLED STUDY; COW; ENDOTHELIUM CELL; MESENCHYME; MUSCLE CELL; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE CONTRACTILITY;

ANIMALS; CALCIUM; CATTLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CELLS, CULTURED; ENDOTHELIAL CELLS; MICROFILAMENT PROTEINS; MUSCLE CELLS; MUSCLE CONTRACTION; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; NITRIC OXIDE; PHOSPHORYLATION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33750050016     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706883     Document Type: Article

References (44)

1. Arciniegas E, Neves CY, Carrillo LM, Zambrano EA, Ramirez R (2005). Endothelial-mesenchymal transition occurs during embryonic pulmonary artery development. Endothelium 12: 193-200.
2. Arciniegas E, Sutton AB, Allen TD, Schor AM (1992). Transforming growth factor β1 promotes the differentiation of endothelial cells into smooth muscle-like cells in vitro. J Cell Sci 103: 521-529.
3. Assoian RK, Fleurdelys BE, Stevenson HC, Miller PJ, Madtes DK, Raines EW et al. (1987). Expression and secretion of type β transforming growth factor by activated human macrophages. Proc Natl Acad Sci USA 84: 6020-6024.
4. Ehrlich HP, Rockwell WB, Cornwell TL, Rajaratnam JB (1991). Demonstration of a direct role for myosin light chain kinase in fibroblast-populated collagen lattice contraction. J Cell Physiol 146: 1-7.
5. 2+-independent contraction in rat embryo fibroblasts. Am J Physiol 286: C8-C21.
6. Feng J, Ito M, Ichikawa K, Isaka N, Nishikawa M, Hartshorne DJ et al. (1999). Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem 274: 37385-37390.
7. Frater-Schroder M, Muller G, Birchmeier W, Bohlen P (1986). Transforming growth factor-b inhibits endothelial cell proliferation. Biochem Biophys Res Commun 137: 295-302.
8. Frid MG, Kale VA, Stenmark KR (2002). Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis. Circ Res 90: 1189-1196.
9. Grainger DJ (2004). Transforming growth factor b and atherosclerosis: so far, so good for the protective cytokine hypothesis. Arterioscler Thromb Vasc Biol 24: 399-404.
10. Hannan RL, Kourembanas S, Flanders KC, Rogelj SJ, Roberts AB, Faller DV et al. (1988). Endothelial cells synthesize basic fibroblast growth factor and transforming growth factor β. Growth Factors 1: 7-17.
11. Heimark RL, Twardzik DR, Schwartz SM (1986). Inhibition of endothelial regeneration by type-β transforming growth factor from platelets. Science 233: 1078-1080.
12. Inoue N, Venema RC, Sayegh HS, Ohara Y, Murphy TJ, Harrison DG (1995). Molecular regulation of the bovine endothelial cell nitric oxide synthase by transforming growth factor-β1. Arterioscler Thromb Vasc Biol 15: 1255-1261.
13. Ito M, Nakano T, Erdodi F, Hartshorne DJ (2004). Myosin phosphatase: structure, regulation and function. Mol Cell Biochem 259: 197-209.
14. Kanzaki T, Tamura K, Takahashi K, Saito Y, Akikusa B, Oohashi H et al. (1995). In vivo effect of TGF-β1. Enhanced intimal thickening by administration of TGF-β1 in rabbit arteries injured with a balloon catheter. Arterioscler Thromb Vasc Biol 15: 1951-1957.
15. Kimura C, Cheng W, Hisadome K, Wang YP, Koyama T, Karashima Y et al. (2002). Superoxide anion impairs contractility in cultured aortic smooth muscle cells. Am J Physiol 283: H382-H390.
16. Kimura C, Koyama T, Oike M, Ito Y (2000). Hypotonic stress-induced NO production in endothelium depends on endogenous ATP. Biochem Biophys Res Commun 274: 736-740.
17. 2+ mobilizing properties in migrating endothelial cells. Am J Physiol 281: H745-H754.
18. Kimura C, Oike M, Koyama T, Ito Y (2001b). Impairment of endothelial nitric oxide production by acute glucose overload. Am J Physiol 280: E171-E178.
19. Kimura C, Oike M, Ohnaka K, Nose Y, Ito Y (2004). Constitutive nitric oxide production in bovine aortic and brain microvascular endothelial cells: a comparative study. J Physiol (London) 554: 721-730.
20. Knudsen HL, Frangos JA (1997). Role of cytoskeleton in shear stressinduced endothelial nitric oxide production. Am J Physiol 273: H347-H355.
21. Kojima H, Nakatsubo N, Kikuchi K, Kawahara S, Kirino Y, Nagoshi H et al. (1998). Detection and imaging of nitric oxide with novel fluorescent indicators: diaminofluoresceins. Anal Chem 70: 2446-2453.
22. 2+-independent myosin II phosphorylation and contraction in chicken embryo fibroblasts. J Physiol (London) 515: 87-92.
23. Koyama T, Oike M, Ito Y (2001). Involvement of Rho-kinase and tyrosine kinase in hypotonic stress-induced ATP release in bovine aortic endothelial cells. J Physiol (London) 532: 759-769.
24. Krizbai IA, Bauer H, Amberger A, Hennig B, Szabo H, Fuchs R et al. (2000). Growth factor-induced morphological, physiological and molecular characteristics in cerebral endothelial cells. Eur J Cell Biol 79: 594-600.
25. Mallat Z, Gojova A, Marchiol-Fournigault C, Esposito B, Kamate C, Merval R et al. (2001). Inhibition of transforming growth factor-β signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ Res 89: 930-934.
26. McCaffrey TA (2000). TGF-βs and TGF-β receptors in atherosclerosis. Cytokine Growth Factor Rev 11: 103-114.
27. Minshall RD, Sessa WC, Stan RV, Anderson RG, Malik AB (2003). Caveolin regulation of endothelial function. Am J Physiol 285: L1179-L1183.
28. Myit S, Delafontaine P, Bochaton-Piallat ML, Giraud S, Gabbiani G, Brink M (2003). Different growth properties of neointimal and medial smooth muscle cells in response to growth factors. J Vasc Res 40: 97-104.
29. 2+ responses in bovine aortic endothelial cells. Am J Physiol 279: H630-H638.
30. Paranya G, Vineberg S, Dvorin E, Kaushal S, Roth SJ, Rabkin E et al. (2001). Aortic valve endothelial cells undergo transforming growth factor-β-mediated and non-transforming growth factor-β-mediated transdifferentiation in vitro. Am J Pathol 159: 1335-1343.
31. Pfitzer G (2001). Invited review: regulation of myosin phosphorylation in smooth muscle. J Appl Physiol 91: 497-503.
32. Pollman MJ, Naumovski L, Gibbons GH (1999). Vascular cell apoptosis: cell type-specific modulation by transforming growth factor-beta;1 in endothelial cells versus smooth muscle cells. Circulation 99: 2019-2026.
33. Poppa V, Miyashiro JK, Corson MA, Berk BC (1998). Endothelial NO synthase is increased in regenerating endothelium after denuding injury of the rat aorta. Arterioscler Thromb Vasc Biol 18: 1312-1321.
34. Roberts AB, Sporn MB (1993). Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 8: 1-9.
35. Robertson AK, Rudling M, Zhou X, Gorelik L, Flavell RA, Hansson GK (2003). Disruption of TGF-β signaling in T cells accelerates atherosclerosis. J Clin Invest 112: 1342-1350.
36. Ross R, Raines EW, Bowen-Pope DF (1986). The biology of plateletderived growth factor. Cell 46: 155-169.
37. Saura M, Zaragoza C, Cao W, Bao C, Rodriguez-Puyol M, Rodriguez-Puyol D et al. (2002). Smad2 mediates transforming growth factorb induction of endothelial nitric oxide synthase expression. Circ Res 91: 806-813.
38. Schiffrin EL (2005). Vascular endothelin in hypertension. Vascul Pharmacol 43: 19-29.
39. Schwartz EA, Reaven E, Topper JN, Tsao PS (2005). Transforming growth factor-β receptors localize to caveolae and regulate endothelial nitric oxide synthase in normal human endothelial cells. Biochem J 390: 199-206.
40. Somlyo AP, Somlyo AV (1994). Signal transduction and regulation in smooth muscle. Nature 372: 231-236.
41. Sutton AB, Canfield AE, Schor SL, Grant ME, Schor AM (1991). The response of endothelial cells to TGF b-1 is dependent upon cell shape, proliferative state and the nature of the substratum. J Cell Sci 99: 777-787.
42. Tai SC, Robb GB, Marsden PA (2004). Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel. Arterioscler Thromb Vasc Biol 24: 405-412.
43. Verin AD, Wang P, Garcia JG (2000). Immunochemical characterization of myosin-specific phosphatase 1 regulatory subunits in bovine endothelium. J Cell Biochem 76: 489-498.
44. Yue TL, Wang XK, Olson B, Feuerstein G (1994). Interleukin-1β (IL-1β) induces transforming growth factor-β (TGF-β1) production by rat aortic smooth muscle cells. Biochem Biophys Res Commun 204: 1186-1192.