New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 23, 2006, Pages 8066-8072

  Choudhary, Muhammad Iqbal ^a   Fatima, Naheed ^a   Khan, Khalid M ^a   Jalil, Saima ^a   Iqbal, Sajjid ^a   Atta ur Rahman, ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Biscoumarins; Cytotoxicity; Enzyme inhibition; Human recombinant phosphodiesterase; Kinetics; Nucleotide pyrophosphatase phosphodiesterase 1; PC 1

Indexed keywords

4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 1H INDOL 2 YLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 1H PYRROL 2 YLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 2 BROMOPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 2 CHLOROPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 2 METHOXYPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 2 PHENYLETHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 2 PYRIDINYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 2 THIENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 3 AMINOPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 3 CHLOROPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 3 ETHOXYPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 3 HYDROXYPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 3 METHOXYPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 3 NITROPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 3 PYRIDINYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 3 THIENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 3,4 DIMETHOXYPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 3,4,5 TRIMETHOXYPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 4 HYDROXY 3 ETHOXYPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 4 ISOPROPYLPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 4 METHOXYPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 4 N,N DIMETHYLAMINOPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 4 NITROPHENYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL) 4 PYRIDINYLMETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL)ETHYL] 2H CHROMEN 2 ONE; 4 HYDROXY 3 [(4 HYDROXY 2 OXO 2H CHROMEN 3 YL)METHYL] 2H CHROMEN 2 ONE; COUMARIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INCUBATION TIME;

CELL DEATH; COUMARINS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; PHOSPHODIESTERASE I; PHOSPHORIC DIESTER HYDROLASES; PYROPHOSPHATASES; SNAKE VENOMS;

EID: 33750046652     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.037     Document Type: Article

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