The A431E mutation in PSEN1 causing Familial Alzheimer's Disease originating in Jalisco State, Mexico: An additional fifteen families

Neurogenetics

Volumn 7, Issue 4, 2006, Pages 277-279

  Murrell, Jill ^a   Ghetti, Bernardino ^a   Cochran, Elizabeth ^b   Macias Islas, Miguel Angel ^c   Medina, Luis ^d   Varpetian, Arousiak ^e   Cummings, Jeffrey L ^d,f   Mendez, Mario F ^d   Kawas, Claudia ^g   Chui, Helena ^e   Ringman, John M ^d  

^a INDIANA UNIVERSITY   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF GUADALAJARA   (Mexico)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

A431E; Ala431Glu; Alzheimer's disease; Founder effect; Mexican; Presenilin 1

Indexed keywords

ALANINE; GLUTAMINE; PRESENILIN 1;

ADULT; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CLINICAL ARTICLE; FAMILIAL DISEASE; FOUNDER EFFECT; GENE; GENE MUTATION; HUMAN; MEXICO; PRIORITY JOURNAL; PSEN1 GENE;

ADULT; AGE OF ONSET; ALZHEIMER DISEASE; FAMILY HEALTH; FOUNDER EFFECT; GENES, DOMINANT; HUMANS; MEXICO; POINT MUTATION; PRESENILIN-1;

EID: 33750037617     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10048-006-0053-1     Document Type: Article

References (5)

1. Yescas P, Huertas-Vazquez A, Villarreal-Molina MT, Rasmussen A, Tusie-Luna MT, Lopez M, Canizales-Quinteros S, Alonso ME (2006) Founder effect for the Ala431Glu mutation of the presenilin 1 gene causing early-onset Alzheimer's disease in Mexican families. Neurogenetics (electronic publication ahead of print)
2. Ringman JM, Diaz-Olavarrieta C, Rodriguez Y, Chavez M, Fairbanks L, Paz F, Varpetian A, Maldonado HC, Macias-Islas MA, Murrell J, Ghetti B, Kawas C (2005) Neuropsychological function in nondemented carriers of presenilin-1 mutations. Neurology 65:552-558
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