Founder effect for the Ala431Glu mutation of the presenilin 1 gene causing early-onset Alzheimer's disease in Mexican families

Neurogenetics

Volumn 7, Issue 3, 2006, Pages 195-200

  Yescas, Petra ^a,b   Huertas Vazquez, Adriana ^c   Villarreal Molina, María Teresa ^c   Rasmussen, Astrid ^a   Tusié Luna, María Teresa ^c   López, Marisol ^d   Canizales Quinteros, Samuel ^c   Alonso, María Elisa ^a  

^a NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

^b UNIVERSIDAD AUTÓNOMA METROPOLITANA   (Mexico)

^c INSTITUTO DE INVESTIGACIONES BIOMÉDICAS   (Mexico)

^d DEPARTAMENTO DE SISTEMAS BIOLÓGICOS   (Mexico)

Author keywords

Early onset Alzheimer's disease; Founder effect; Mutation; PSEN1 gene

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; GENOMIC DNA; PRESENILIN 1; PRESENILIN 2;

ADULT; ALZHEIMER DISEASE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CONTROLLED STUDY; DNA SEQUENCE; FAMILIAL DISEASE; FEMALE; FOUNDER EFFECT; GENETIC COUNSELING; GENETIC POLYMORPHISM; HAPLOTYPE; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MALE; MEXICO; MICROSATELLITE MARKER; MISSENSE MUTATION; MOLECULAR GENETICS; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; POPULATION GENETICS; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEINS E; CASE-CONTROL STUDIES; DNA MUTATIONAL ANALYSIS; FEMALE; FOUNDER EFFECT; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENETIC TESTING; HUMANS; MALE; MEXICO; MIDDLE AGED; MUTATION, MISSENSE; POLYMORPHISM, GENETIC; PRESENILIN-1;

EID: 33746103277     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10048-006-0043-3     Document Type: Article

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