Serotonin transporter gene polymorphisms in irritable bowel syndrome

Neurogastroenterology and Motility

Volumn 18, Issue 11, 2006, Pages 957-959

  Geeraerts, B ^a   Van Oudenhove, L ^a   Tack, J ^a,b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALOSETRON; SEROTONIN 3 ANTAGONIST; SEROTONIN TRANSPORTER;

CLINICAL FEATURE; CONSTIPATION; DIARRHEA; DISEASE MODEL; DRUG EFFECT; DRUG RESPONSE; EDITORIAL; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC POLYMORPHISM; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INTESTINE TRANSIT TIME; IRRITABLE COLON; MENTAL DISEASE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PHARMACOGENETICS; PRIORITY JOURNAL; SERT GENE; SYMPTOM; VARIABLE NUMBER OF TANDEM REPEAT;

ANIMALS; HUMANS; IRRITABLE BOWEL SYNDROME; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 33750001719     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2006.00854.x     Document Type: Editorial

References (19)

1. Guilera M, Balboa A, Mearin F. Bowel habit subtypes and temporal patterns in irritable bowel syndrome: systematic review. Am J Gastroenterol 2005; 100: 1174-84.
2. Gershon MD. Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther 1999; 13 (Suppl. 2): 15-30.
3. Fuller RW, Wong DT. Serotonin uptake and serotonin uptake inhibition. Ann N Y Acad Sci 1990; 600: 68-78 (discussion 79-80).
4. Chen JJ, Li Z, Pan H et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: abnormal intestinal motility and the expression of cation transporters. J Neurosci 2001; 21: 6348-61.
5. Tack J, Broekaert D, Corsetti M, Fischler B, Janssens J. Influence of acute serotonin reuptake inhibition on colonic sensorimotor function in man. Aliment Pharmacol Ther 2006; 23: 265-74.
6. Lesch KP, Balling U, Gross J et al. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 1994; 95: 157-62.
7. Heils A, Teufel A, Petri S et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 2621-4.
8. Lesch KP, Bengel D, Heils A et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-31.
9. Pata C, Erdal ME, Derici E, Yazar A, Kanik A, Ulu O. Serotonin transporter gene polymorphism in irritable bowel syndrome. Am J Gastroenterol 2002; 97: 1780-4.
10. Yeo A, Boyd P, Lumsden S et al. Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut 2004; 53: 1452-8.
11. Kim HJ, Camilleri M, Carlson PJ et al. Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut 2004; 53: 829-37.
12. Park JM, Choi MG, Park JA et al. Serotonin transporter gene polymorphism and irritable bowel syndrome. Neurogastroenterol Motil 2006; 18: 995-1000.
13. Camilleri M, Atanasova E, Carlson PJ et al. Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology 2002; 123: 425-32.
14. Masson J, Sagne C, Hamon M, El Mestikawy S. Neurotransmitter transporters in the central nervous system. Pharmacol Rev 1999; 51: 439-64.
15. Holmes A, Lit Q, Murphy D et al. Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav 2003; 2: 365-80.
16. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 2004; 306: 879-81.
17. Hariri AR, Holmes A. Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci 2006; 10: 182-91.
18. Mayer EA, Craske M, Naliboff BD. Depression, anxiety, and the gastrointestinal system. J Clin Psychiatry 2001; 62 (Suppl. 8): 28-36 (discussion 37).
19. Van Oudenhove L, Demyttenaere K, Tack J, Aziz Q. Central nervous system involvement in functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 2004; 18: 663-80.