Mechanisms of action of uroguanylin and guanylin and their role in salt handling

Nephrology Dialysis Transplantation

Volumn 21, Issue 11, 2006, Pages 3007-3012

  Sindić, Aleksandra ^a   Schlatter, Eberhard ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Arachidonic acid; cGMP; G protein; Guanylate cyclase C; kidney; Natriuretic peptides

Indexed keywords

AQUAPORIN; ARACHIDONIC ACID; ATRIAL NATRIURETIC FACTOR; CYCLIC GMP; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANYLATE CYCLASE; GUANYLIN; MESSENGER RNA; NATRIURETIC FACTOR; PHOSPHOLIPASE A2; POTASSIUM CHANNEL; SODIUM CHANNEL; SODIUM CHLORIDE; UROGUANYLIN;

CHANNEL GATING; CHRONIC KIDNEY FAILURE; CONCENTRATION (PARAMETERS); DIURESIS; GLOMERULONEPHRITIS; GLOMERULUS; HEMODIALYSIS; HUMAN; ION TRANSPORT; ISOLATED KIDNEY; KALIURESIS; KIDNEY COLLECTING TUBULE; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE; KIDNEY TUBULE CELL; MEDICAL RESEARCH; MEMBRANE POTENTIAL; MOUSE; NATRIURESIS; NEPHROTIC SYNDROME; NONHUMAN; NOTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; RECEPTOR UPREGULATION; SALT INTAKE; SIGNAL TRANSDUCTION; SODIUM EXCRETION;

ANIMALS; GASTROINTESTINAL HORMONES; HUMANS; NATRIURETIC PEPTIDES; SALTS;

EID: 33749999555     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfl314     Document Type: Note

References (36)

1. Kuhn M. Molecular physiology of natriuretic peptide signalling. Basic Res Cardiol 2004; 99: 76-82
2. Currie MG, Fok KF, Kato J et al. Guanylin: An endogenous activator of intestinal guanylate cyclase. Proc Natl Acad Sci USA 1992; 89: 947-951
3. Hamra FK, Forte LR, Eber SL et al. Uroguanylin: Structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase. Proc Natl Acad Sci USA 1993; 90: 10464-10468
4. Yuge S, Inoue K, Hyodo S, Takei Y. A novel guanylin family (guanylin, uroguanylin, and renoguanylin) in eels: Possible osmoregulatory hormones in intestine and kidney. J Biol Chem 2003; 278: 22726-22733
5. Forte LR, Eber SL, Fan X et al. Lymphoguanylin: Cloning and characterization of a unique member of the guanylin peptide family. Endocrinology 1999; 140: 1800-1806
6. Cetin Y, Kuhn M, Kulaksiz H et al. Enterochromaffin cells of the digestive system: Cellular source of guanylin, a guanylate cyclase-activating peptide. Proc Natl Acad Sci USA 1994; 91: 2935-2939
7. Perkins A, Goy MF, Li Z. Uroguanylin is expressed by enterochromaffin cells in the rat gastrointestinal tract. Gastroenterology 1997; 113: 1007-1014
8. Sindic A, Schlatter E. Cellular effects of guanylin and uroguanylin. J Am Soc Nephrol 2006; 17: 607-616
9. Lennane RJ, Peart WS, Carey R, Shaw JA. Comparison of natriuresis after oral and intravenous sodium loading in sodium-depleted rabbits: Evidence for a gastrointestinal or portal monitor of sodium intake. Clin Sci Mol Med 1975; 49: 433-436
10. Fonteles MC, Greenberg RN, Monteiro HSA, Currie MG, Forte LR. Natriuretic and kaliuretic activities of guanylin and uroguanylin in the isolated perfused rat kidney. Am J Physiol 1998; 275: F191-F197
11. Lorenz JN, Nieman M, Sabo J et al. Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load. J Clin Invest 2003; 122: 1244-1254
12. Carrithers SL, Ott CE, Hill MJ et al. Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor. Kidney Int 2004; 65: 40-53
13. Carrithers SL, Hill MJ, Johnson BR et al. Renal effects of uroguanylin and guanylin in vivo. Braz J Med Biol Res 1999; 32: 2-8
14. Greenberg RN, Hill MJ, Crytzer J et al. Comparison of effects of uroguanylin, guanylin and Escherichia coli heat-stable enterotoxin STa in mouse intestine and kidney: Evidence that uroguanylin is an intestinal natriuretic hormone. J Invest Med 1997; 45: 276-283
15. Wang T, Kawabata M, Haneda M, Takabatake T. Effects of uroguanylin, an intestinal natriuretic peptide, on tubuloglomerular feedback. Hypertens Res 2003; 26: 577-582
16. Fukae H, Kinoshita H, Fujimoto S, Kita T, Nakazato M, Eto T. Changes in urinary levels and renal expression of uroguanylin on low or high salt diets in rats. Nephron 2002; 92: 373-378
17. Nakazato M, Yamaguchi H, Date Y et al. Tissue distribution, cellular source, and structural analysis of rat immunoreactive uroguanylin. Endocrinology 1998; 139: 5247-5254
18. Potthast R, Ehler E, Scheving LA, Sindic A, Schlatter E, Kuhn M. High salt intake increases uroguanylin expression in mouse kidney. Endocrinology 2001; 142: 3087-3097
19. Kinoshita H, Fujimoto S, Nakazato M et al. Urine and plasma levels of uroguanylin and its molecular form in renal diseases. Kidney Int 1997; 52: 1028-1034
20. Fan X, Wang Y, London RM et al. Signalling pathways for guanylin and uroguanylin in the digestive, renal, central nervous, reproductive, and lymphoid systems. Endocrinology 1997; 138: 4636-4648
21. Forte LR, Krause WJ, Freeman RH. Receptors and cGMP signalling mechanism for E. coli enterotoxin in Opossum kidney. Am J Physiol 1988; 255: F1040-F1046
22. London RM, Eber SL, Visweswariah SS, Krause WJ, Forte LR. Structure and activity of OK-GC: A kidney receptor guanylate cyclase activated by guanylin peptides. Am J Physiol 1999; 276: F882-F891
23. Sindic A, Basoglu C, Cerci A et al. Guanylin, uroguanylin, and heat-stable enterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells. J Biol Chem 2002; 277: 17758-17764
24. Anand-Srivastava MB, Sehl PD, Lowe DG. Cytoplasmatic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase: Involvement of a pertussis toxin-sensitive G protein. J Biol Chem 1996; 271: 19324-19329
25. Murthy KS, Makhlouf GM. Identification of the G protein-activating domain of the natriuretic peptide clearance receptor (NPR-C). J Biol Chem 1999; 274: 17587-17592
26. Sindic A, Hirsch JR, Velic A, Piechota H, Schlatter E. Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts. Kidney Int 2005; 67: 1420-1427
27. Sindic A, Velic A, Basoglu C et al. Uroguanylin and guanylin regulate transport of mouse cortical collecting duct independent of guanylate cyclase C. Kidney Int 2005; 68: 1008-1017
28. Hamra FK, Fan X, Krause WJ et al. Prouroguanylin and proguanylin: purification from colon, structure and modulation of bioactivity by proteases. Endocrinology 1996; 137: 257-265
29. + channel, ROMK1. Am J Physiol 1996; 271: F588-F594
30. Furuya S, Naruse S, Ando E, Nikohara K, Hayakawa T. Effect and distribution of intravenously injected 125I-guanylin in rat kidney examined by high-resolution light microscopic radioautography. Anat Embryol 1997; 196: 185-193
31. Min/+ mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Cancer Res 2000; 60: 5151-5157
32. Nakazato M, Yamaguchi H, Kinoshita H et al. Identification of biologically active and inactive human uroguanylins in plasma and urine and their increases in renal insufficiency. Biochem Biophys Res Commun 1996; 220: 586-593
33. Nakazato M, Yamaguchi H, Shiomi K et al. Identification of 10-kDa proguanylin as a major guanylin molecule in human intestine and plasma and its increase in renal insufficiency. Biochem Biophys Res Commun 1994; 205: 1966-1975
34. Kinoshita H, Fujimoto S, Fukae H et al. Plasma and urine levels of uroguanylin a new peptide in nephrotic syndrome. Nephron 1999; 81: 160-164
35. Fukae H, Kinoshita H, Fujimoto S, Nakazato M, Eto T. Plasma concentration of uroguanylin in patients on maintenance dialysis therapy. Nephron 2000; 84: 206-210
36. Kikuchi M, Fujimoto S, Fukae H et al. Role of uroguanylin, a peptide with natriuretic activity, in rats with experimental nephrotic syndrome. J Am Soc Nephrol 2005; 16: 392-397