Effects of Atenolol and Metoprolol on cardiomyocyte apoptosis and related gene expression after acute myocardial infarction in rats

Acta Academiae Medicinae Sinicae

Volumn 28, Issue 4, 2006, Pages 538-543

  Chen, Yue Feng ^a,b   Yang, Yue Jin ^a   Chen, Xi ^a,b   Ruan, Ying Mao ^a   Sun, Rui Cheng ^a   Tian, Yi ^a   Zhou, Yan Wen ^a   Wang, Qing Zhi ^a   Si, Wen Xue ^a   Chen, Ji Lin ^a   Gao, Run Lin ^a   Chen, Zai Jia ^a  

^a FUWAI HOSPITAL   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Atenolol; Gene; Metoprolol; Myocardial infarction

Indexed keywords

ATENOLOL; CASPASE 3; DNA; METOPROLOL; PROTEIN BAX; PROTEIN BCL 2;

ACUTE HEART INFARCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG DOSE REGIMEN; DRUG EFFICACY; EXPERIMENTAL MODEL; FEEDING; FEMALE; GENE EXPRESSION; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; NICK END LABELING; NONHUMAN; OPERATION DURATION; PROTEIN EXPRESSION; RANDOMIZATION; RAT; RAT STRAIN; SCAR; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STOMACH; WESTERN BLOTTING;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; APOPTOSIS; ATENOLOL; BCL-2-ASSOCIATED X PROTEIN; FEMALE; METOPROLOL; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33749820223     PISSN: 1000503X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Sam F, Sawyer DB, Chang DL, et al. Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart. Am J Physiol Heart Circ Physiol, 2000, 279 (1):H422-H428.
2. Palojoki E, Saraste A, Eriksson A, et al. Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats. Am J Physiol Heart Circ Physiol, 2001, 280(6): H2726-H2731.
3. Waagstein F, Stromblad O, Andersson B, et al. Increased exercise ejection fraction and reversed remodeling after long-term treatment with metoprolol in congestive heart failure: a randomized, stratified, double-blind, placebo-controlled trial in mild to moderate heart failure due to ischemic or idiopathic dilated cardiomyopathy. Eur J Heart Fail, 2003, 5 (5): 679-691.
4. Shizukuda Y, Buttrick PM, Geenen DL, et al. Beta-adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy. Am J Physiol, 1998, 275(3 Pt 2):H961-H968.
5. Weisman HF, Bush DE, Mannisi JA, et al. Cellular mechanisms of myocardial infarct expansion. Circulation, 1988, 78 (1):186-201.
6. Yang YJ, Tang YD, Ruan YM, et al. Comparative effects of carvedilol and losartan alone and in combination for preventing left ventricular remodeling after acute myocardial infarction in rats. Circ J, 2003, 67(2):159-162.
7. Pfeffer JM, Pfeffer MA, Braunwald E. Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ Res, 1985, 57(1):84-95.
8. Cheng W, Kajstura J, Nitahara JA, et al. Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res, 1996, 226(2):316-327.
9. Bialik S, Geenen DL, Sasson IE, et al. Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest, 1997, 100(6):1363-1372.
10. Shimada K, Nishikimi T, Kawarabayashi T, et al. Effect of prolonged beta-adrenergic blockade induced by atenolol on left ventricular remodeling after acute myocardial infarction in the rat. Jpn Heart 1, 1995, 36(1):81-89.
11. Heesch CM, Marcoux L, Hatfield B, et al. Hemodynamic and energetic comparison of bucindolol and metoprolol for the treatment of congestive heart failure. Am J Cardiol, 1995, 75(5): 360-364.
12. Zaugg M, Xu W, Lucchinetti E, et al. Beta-adrenergic receptor subtypes differentially affect apoptosis in adult rat ventricular myocytes. Circulation, 2000, 102(3):344-350.
13. Sabbah HN, Sharov VG, Gupta RC, et al. Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure. J Am Coll Cardiol, 2000, 36(5):1698-1705.
14. Prabhu SD, Wang G, Luo J, et al. Beta-adrenergic receptor blockade modulates Bcl-X (5) expression and reduces apoptosis in failing myocardium. J Mol Cell Cardiol, 2003, 35(5): 483-493.
15. Cook SA, Sugden PH, Clerk A. Regulation of bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: association with changes in mitochondrial membrane potential. Circ Res, 1999, 85(10):940-949.
16. Misao J, Hayakawa Y, Ohno M, et al. Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction. Circulation, 1996, 94(7):1506-1512.