Development of a high-throughput assay to measure histidine decarboxylase activity

Journal of Biomolecular Screening

Volumn 11, Issue 7, 2006, Pages 816-821

  August, E Michael ^a   Patnaude, Lori ^a   Hopkins, Jerry ^a   Studts, Joey ^a   Gautschi, Elda ^a   Shrutkowski, Anthony ^a   Kronkaitis, Anthony ^a   Brown, Martha ^a   Kabcenell, Alisa ^a   Rajotte, Daniel ^a,b  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b Research and Development   (Canada)

Author keywords

Fluorescence polarization; Histamine; Histidine decarboxylase; Screening

Indexed keywords

ALPHA FLUOROMETHYL HISTIDINE; HISTAMINE; HISTAMINE RECEPTOR; HISTIDINE DECARBOXYLASE; HISTIDINE DECARBOXYLASE INHIBITOR; HISTIDINE METHYL ESTER; HISTIDINE PHENYLALANINE; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ARTICLE; AUTOMATION; BONE REMODELING; CELL MATURATION; DRUG HYPERSENSITIVITY; DRUG POTENCY; ENZYME ACTIVITY; FLUORESCENCE POLARIZATION; HIGH THROUGHPUT SCREENING; HISTAMINE BLOOD LEVEL; HISTAMINE RELEASE; HUMAN; HUMAN CELL; INFLAMMATION; NEUROLOGIC DISEASE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ENZYME INHIBITORS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENCE POLARIZATION; HISTAMINE; HISTAMINE ANTAGONISTS; HISTIDINE; HISTIDINE DECARBOXYLASE; HUMANS; INHIBITORY CONCENTRATION 50; TIME FACTORS;

EID: 33749817750     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057106290803     Document Type: Article

References (21)

1. Jutel M, Watanabe T, Akdis M, Blaser K, Akdis CA: Immune regulation by histamine. Curr Opin Immunol 2002;14:735-740.
2. Schneider E, Rolli-Derkinderen M, Arock M, Dy M: Trends in histamine research: new functions during immune responses and hematopoiesis. Trends Immunol 2002;23:255-263.
3. Fung-Leung WP, Thurmond RL, Ling P, Karlsson L: Histamine H4 receptor antagonists: the new antihistamines? Curr Opin Investig Drugs 2004; 5:1174-1183.
4. Ohtsu H, Watanabe T: New functions of histamine found in histidine decarboxylase gene knockout mice. Biochem Biophys Res Commun 2003;305:443-447.
5. Christen P, Mehta P: From cofactor to enzymes: the molecular evolution of pyridoxal-5′-phosphate-dependent enzymes. Chem Rec 2001;1:436-447.
6. Yatsunami K, Tsuchikawa M, Kamada M, Hori K, Higuchi T: Comparative studies of human recombinant 74- and 54-kDa L-histidine decarboxylase. J Biol Chem 1995;270:30813-30817.
7. Tanaka S, Nemoto K, Yamamura E, Ohmura S, Ichikawa A: Degradation of the 74 kDa form of 1-histidine decarboxylase via the ubiquitin-proteasome pathway in a rat basophilic/mast cell line (RBL-2H3). FEBS Lett 1997;417:203-207.
8. Ohtsu H, Tanaka S, Terui T, Hori Y, Makabe-Kobayashi Y, Pejler G, et al: Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Le 2001;502:53-56.
9. Kozma GT, Losonczy G, Keszei M, Komlosi Z, Buzas E, Pallinger E, et al: Histamine deficiency in gene-targeted mice strongly reduces antigen-induced airway hyper-responsiveness, eosinophilia and allergen-specific IgE. Int Immunol 2003;15:963-973.
10. Ohtsu H, Kuramasu A, Tanaka S, Terui T, Hirasawa N, Hara M, et al: Plasma extavasation induced by dietary supplemented histamine in histamine-free mice. Eur J Immunol 2002;32:1698-1708.
11. Ghosh AK, Hirasawa N, Ohtsu H, Watanabe T, Ohuchi K: Defective angiogenesis in the inflammatory granulation tissue in histidine decarboxylase-deficient mice but not in mast cell-deficient mice. J Exp Med 2002;195:973-982.
12. Fitzpatrick LA, Buzas E, Gagne TJ, Nagy A, Horvath C, Ferencz V, et al: Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss. Proc Natl Acad Sci U S A 2003;100:6027-6032.
13. Pos Z, Safrany G, Muller K, Toth S, Falus A, Hegyesi H: Phenotypic profiling of engineered mouse melanomas with manipulated histamine production identifies histamine H2 receptor and rho-C as histamine-regulated melanoma progression markers. Cancer Res 2005;65:4458-4466.
14. Watanabe T, Yamatodani A, Maeyama K, Wada H: Pharmacology of α-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase. Trends Pharmaco Sci 1990;11:363-367.
15. Shore PA, Burkhalter A, Cohn VH: A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther 1959;127:182-186.
16. Price JA: Microplate assay for measurement of histamine release from mast cells. Biotechniques 1997;22:958-962.
17. Claret EJ, Ouled-Diaf J, Seguin P: Homogenous time resolved fluorescence assay to measure histamine release. Comb Chem High Throughput Screen 2003;6:789-794.
18. Owicki JC: Fluorescence polarization and anisotropy in high throughput screening: perspective and primers. J Biomol Screen 2000;5:297-306.
19. Guesdon JL, Chevrier D, Mazie JC, David B, Avrameas S: Monoclonal anti-histamine antibody: preparation, characterization and application to enzyme immunoassay of histamine. J Immunol Methods 1986;87:69-78.
20. Watabe A, Fukui T, Ohmori E, Ichikawa A: Purification and properties of L-histidine decarboxylase from mouse stomach. Biochem Pharmacol 1992;43:587-593.
21. Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN: Structural insight into Parkinson's disease treatment from drug-induced DOPA decarboxylase. Nat Struct Biol 2001;8:963-967.