Palladium catalyzed α-arylation of methyl isobutyrate and isobutyronitrile: an efficient synthesis of 2,5-disubstituted benzyl alcohol and amine intermediates

Tetrahedron Letters

Volumn 47, Issue 46, 2006, Pages 8021-8024

  Shetty, Rupa ^a   Moffett, Kristofer K ^a  

^a Locus Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYL ALCOHOL; BENZYLAMINE DERIVATIVE; BUTYRIC ACID DERIVATIVE; ISOBUTYRONITRILE; METHYL ISOBUTYRATE; PALLADIUM; UNCLASSIFIED DRUG;

ARTICLE; ARYLATION; CATALYST; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 33749622415     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.09.059     Document Type: Article

References (8)

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8. 4, filtered, concentrated and the crude chromatographed on silica gel using 10:1 hexanes:EtOAc to give 1.0 g of the desired nitrile.