Sterically hindered complexes of platinum(II) with planar heterocyclic nitrogen donors. A novel complex with 1-methyl-cytosine has a spectrum of activity different from cisplatin and is able of overcoming acquired cisplatin resistance

Journal of Inorganic Biochemistry

Volumn 100, Issue 11, 2006, Pages 1849-1857

  Margiotta, Nicola ^a   Natile, Giovanni ^a   Capitelli, Francesco ^b   Fanizzi, Francesco P ^c   Boccarelli, Angelina ^a   De Rinaldis, Pietro ^a   Giordano, Domenico ^a   Coluccia, Mauro ^a  

^a UNIVERSITY OF BARI   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF SALENTO   (Italy)

Author keywords

1 Methyl cytosine; 2,9 Dimethyl 1,10 phenanthroline; Antitumoral activity; Cisplatin resistance; Platinum complexes

Indexed keywords

1 METHYLCYTOSINE; CISPLATIN; CYTOSINE DERIVATIVE; NITROGEN; PLATINUM COMPLEX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; CRYSTALLOGRAPHY, X-RAY; CYTOSINE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; ORGANOPLATINUM COMPOUNDS; PLATINUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749576814     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2006.07.010     Document Type: Article

References (34)

1. Cleare M.J., and Hoeschele J.D. Plat. Met. Rev. 17 (1973) 2-13
2. Cleare M.J., and Hoeschele J.D. Bioinorg. Chem. 2 (1973) 187-210
3. Wong E., and Giandomenico C.M. Chem. Rev. 99 (1999) 2451-2466
4. Hollis L.S., Amundsenm A.R., and Stern E.W. J. Med. Chem. 32 (1989) 128-136
5. Fichtinger-Schepman A.M.J., van der Veer J.L., den Hartog J.H.J., Lohman P.H.M., and Reedijk J. Biochemistry 24 (1985) 707-713
6. Coluccia M., Boccarelli A., Cernelli C., Portolani M., and Natile G. Metal-Based Drugs 2 (1995) 249-256
7. Grabner S., Plavec J., Bukovec N., Di Leo D., Cini R., and Natile G. J. Chem. Soc. Dalton Trans. (1998) 1447-1451
8. Balcarova Z., Kasparkova J., Zakovska A., Novakova O., Sivo M.F., Natile G., and Brabec V. Mol. Pharmacol. 53 (1998) 846-855
9. Margiotta N., Bergamo A., Sava G., Padovano G., de Clercq E., and Natile G. J. Inorg. Biochem. 98 (2004) 1385-1390
10. Margiotta N., Fanizzi F.P., Kobe J., and Natile G. Eur. J. Inorg. Chem. (2001) 1303-1310
11. Papadia P., Margiotta N., Bergamo A., Sava G., and Natile G. J. Med. Chem. 48 (2005) 3364-3371
12. Margiotta N., Papadia P., Lazzaro F., Crucianelli M., De Angelis F., Pisano C., Vesci L., and Natile G. J. Med. Chem. 48 (2005) 7821-7828
13. Fanizzi F.P., Intini F.P., Maresca L., Natile G., Lanfranchi M., and Tiripicchio A. J. Chem. Soc. Dalton Trans. (1991) 1007-1015
14. SADABS: area-detector absorption correction, Siemens Industrial Automation, Inc., Madison, WI, 1996.
15. Altomare A., Burla M.C., Camalli M., Cascarano G.L., Giacovazzo C., Guagliardi A., Moliterni A.G., Polidori G., and Spagna R. J. Appl. Crystallogr. 32 (1999) 115-119
16. G.M. Sheldrick, SHELXL-97, Program for the Refinement of Crystal Structures, University of Gottingen, Germany, 1997.
17. Skehan P., Storeng R., Scudiero D., Monks A., McMahon J., Vistica D., Warren J.T., Bokesch H., Kenney S., and Boyd M.R. J. Natl. Cancer Inst. 82 (1990) 1107-1112
18. Fanizzi F.P., Maresca L., Natile G., Lanfranchi M., Tiripicchio A., and Pacchioni G. J. Chem. Soc. Chem. Commun. (1992) 333-335
19. Fanizzi F.P., Lanfranchi M., Natile G., and Tiripicchio A. Inorg. Chem. 33 (1994) 3331-3339
20. Clark R.J.H., Fanizzi F.P., Natile G., Pacifico C., van Rooyen C.G., and Tocher D.A. Inorg. Chim. Acta. 235 (1995) 205-213
21. Margiotta N., Papadia P., Fanizzi F.P., and Natile G. Eur. J. Inorg. Chem. (2003) 1136-1144
22. Margiotta N., Fanizzi F.P., Cini R., Tamasi G., and Natile G. Inorg. Chim. Acta. 339 (2002) 503-512
23. Fanizzi F.P., Margiotta N., Lanfranchi M., Tiripicchio A., Pacchioni G., and Natile G. Eur. J. Inorg. Chem. (2004) 1705-1713
24. Cerasino L., Williams K.M., Intini F.P., Cini R., Marzilli L.G., and Natile G. Inorg. Chem. 36 (1997) 6070-6079
25. Melanson R., and Rochon F.D. Acta Crystallogr. B 33 (1977) 3571-3573
26. Bondi A. J. Phys. Chem. 68 (1964) 441-451
27. Brammer L. J. Chem. Soc. Dalton Trans. (2003) 3145-3157
28. Kato M., Kosuge C., Yano S., and Kimura M. Acta Crystallogr. C 53 (1997) 838-840
29. Capitelli F., Margiotta N., Moliterni A.G.G., and Natile G. Z. Kristallogr. 217 (2002) 492-496
30. Snedecor G.W., and Cochran W.G. Statistical Methods. sixth ed. (1967), Iowa State University Press, Ames, IA pp. 194-195
31. Kelland L.R., Mistry P., Abel G., Loh S.Y., O'Neill C.F., Murrer B.A., and Harrap K.R. Cancer Res. 52 (1992) 3857-3864
32. Hills C.A., Kelland L.R., Abel G., Siracky J., Wilson A.P., and Harrap K.R. Br. J. Cancer 59 (1989) 527-534
33. Zorbas H., and Keppler B.K. ChemBioChem 6 (2005) 1157-1166
34. Reedijk J., and Teuben J.M. In: Lippert B. (Ed). Cisplatin, Chemistry and Biochemistry of a Leading Anticancer Drug (1999), Wiley VCH, Weinheim 339-362