Random chemistry as a new tool for the generation of small-compound libraries

Archiv der Pharmazie

Volumn 339, Issue 9, 2006, Pages 489-497

  Kapková, Petra ^a   Heller, Eberhard ^a   Kugelmann, Eva ^a   Faber, Johan ^a   Bringmann, Gerhard ^a   Kessler, Ulrich ^b   Folkers, Gerd ^b   Holzgrabe, Ulrike ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

irradiation; Bioassay guided fractionation; Random chemistry; Re combinatorial chemistry

Indexed keywords

1 AMINO 3,4 DIHYDROISOQUINOLINE; 3,4 DIHYDRO 1(2H)ISOQUINOLONE; 9 AMINO 5,6,7,8 TETRAHYDRO ACRIDIN 4 YL)METHANOL; ACETYLCHOLINESTERASE; ANTIINFECTIVE AGENT; ANTISPOROZOAL AGENT; BENZYLAMINE; CHEMICAL COMPOUND; CHLOROQUINE; DIAZIRIDINE; DRUG METABOLITE; FERROUS GLUCONATE; ISOQUINOLINE DERIVATIVE; LEAD; MELARSOPROL; METHANOL; MILTEFOSINE; NUCLEOSIDE ANALOG; ORGANIC SOLVENT; PYRIDINIUM DERIVATIVE; TACRINE; TACRINE DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE; THYMIDINE KINASE 1; TOLAZOLINE; UNCLASSIFIED DRUG; VELNACRINE; WATER;

ALZHEIMER DISEASE; BIOASSAY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COBALT THERAPY; DRUG ACTIVITY; DRUG INHIBITION; DRUG ISOLATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; FRACTIONATION; GAMMA RADIATION; GENE EXPRESSION; GENE THERAPY; HERPES SIMPLEX VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; METHODOLOGY; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RADIOLYSIS; REPORTER GENE; SHORT SURVEY;

CHEMISTRY, PHARMACEUTICAL; COMBINATORIAL CHEMISTRY TECHNIQUES; MODELS, THEORETICAL; MOLECULAR STRUCTURE;

EID: 33749576309     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200600084     Document Type: Short Survey

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