MDMA and seizures: A dangerous liaison?

Annals of the New York Academy of Sciences

Volumn 1074, Issue , 2006, Pages 357-364

  Giorgi, Filippo S ^a   Lazzeri, Gloria ^a   Natale, Gianfranco ^a   Iudice, Alfonso ^a   Ruggieri, Stefano ^b,c   Paparelli, Antonio ^a   Murri, Luigi ^a   Fornai, Francesco ^a,c  

^a UNIVERSITY OF PISA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c IRCCS NEUROMED   (Italy)

Author keywords

Dopamine; Kainate; Limbic system; MDMA; Mossy fiber sprouting; Seizures; Serotonin; Status epilepticus

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; COMPLEX PARTIAL SEIZURE; CONFERENCE PAPER; CONTROLLED STUDY; HYPERTHERMIA; HYPONATREMIA; MONOAMINERGIC SYSTEM; MOSSY FIBER; MOUSE; NONHUMAN; SEIZURE; SEIZURE THRESHOLD;

EID: 33749551110     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1369.035     Document Type: Conference Paper

References (26)

1. LANDRY, M.J. 2002. MDMA: a review of epidemiologic data. J. Psychoactive Drugs 34: 163-169.
2. BURGESS, C. et al. 2000. Agony and ecstasy: a review of MDMA effects and toxicity. Eur. Psychiatry 15: 287-294.
3. FISHER, R.S. et al. 2005. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 46: 470-472.
4. LEVINSKY, N.G. 1994. Fluids and electrolytes. In Harrison's Principles of Internal Medicine, 13th ed. K.J. Isselbacher, et al., Eds.: 101-118 Mc Graw-Hill. New York.
5. HARTUNG, T.K. et al. 2002. Hyponatraemic states following 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') injestion. Q. J. Med. 95: 431-437.
6. DAFTERS, R.I. 1994. Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in rats. Psychopharmacology 114: 505-508.
7. JOBE, P.C. & R.A. BROWNING. 2005. The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant. Epilepsy Behav. 7: 602-619.
8. STARR, M.S. 1996. The role of dopamine in epilepsy. Synapse 22: 159-194.
9. GIORGI, F.S. et al. 2004. The role of norepinephrine in epilepsy: from the bench to the bedside. Neurosci. Biobehav. Rev. 28: 507-524.
10. PRENDIVILLE, S. & K. GALE. 1993. Anticonvulsant effect of systemic fluoxetine on focally-evoked limbic motor seizure in rats. Epilepsia 34: 381-384.
11. DAILEY, J.W. et al. 1992. Effects of fluoxetine on convulsions and brain serotonin as detected by microdialysis in genetically epilepsy-prone rats. J. Pharmacol. Exp. Ther. 260: 533-540.
12. SCHMIDT, C.J. et al. 1994. Blockade of striatal 5-hydroxytryptamine 2 receptors reduces the increase in extracellular concentrations of dopamine produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine. J. Neurochem. 62: 1382-1389.
13. GUDELSKY, G.A. & J.F. NASH. 1996. Carrier-mediated release of serotonin by 3,4,-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions. J. Neurochem. 66: 243-249.
14. HANSON, G.R. et al. 1999. Distinct features of seizures induced by cocaine and amphetamine analogs. Eur. J. Pharmacol. 377: 167-173.
15. GIORGI, F.S. et al. 2005. Previous exposure to (±) 3,4-methylenedioxymethamphetamine produces long-lasting alteration in limbic brain excitability measured by electroencephalogram spectrum analysis, brain metabolism and seizure susceptibility. Neuroscience 136: 43-53.
16. COLADO, M.I. et al. 2001. A study of the mechanisms involved in the neurotoxic effects of 3,4 methylenedioxymethamphetamine (MDMA, ecstasy) on dopamine neurons in mouse brain. Br. J. Pharmacol. 134: 1711-1723.
17. ALI, S.F. et al. 1993. Oral administration of 3,4- methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate. Neurotoxicol. Teratol. 15: 91-96.
18. RICAURTE, G.A. et al. 1988. (±)3,4-Methylenedioxymethamphetamine selectevely damages central serotonergic neurons in nonhuman primates. JAMA 260: 51-56.
19. RICAURTE, G.A. et al. 1992. Lasting effects of (±)3,4- methylenedioxymethamphetamine (MDMA) on central serotoninergic neurons in nonhuman primates: neurochemical observations. J. Pharmacol. Exp. Ther. 261: 616-622.
20. MCCANN, U.D. et al. 1994. Serotonin neurotoxicity after (±)3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy"): a controlled study in humans. Neuropsychopharmacology 10: 129-138.
21. MCKHANN, G.M. et al. 2003. Mouse strain differences in kainic acid sensitivity, seizure behaviour, mortality, and hippocampal pathology. Neuroscience 122: 551-561.
22. FORNAI, F. et al. 2001. Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice. Synapse 39: 213-221.
23. TAUCK, D.L. & J.V. NADLER. 1985. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J. Neurosci. 5: 1016-1022.
24. NADLER, J.V. et al. 1980. Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid. Brain Res. 182: 1-9.
25. DANSCHER, G. 1981. Histochemical demonstration of heavy metals: a revised version of the sulphide silver method suitable for both light and electronmicroscopy. Histochemistry 71: 1-16.
26. LONGO, B.M. & L.E. MELLO. 1998. Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat. Epilepsy Res. 32: 172-182.