메뉴 건너뛰기




Volumn 53, Issue 5, 2006, Pages 293-300

Tigecycline: The answer to beta-lactam and fluoroquinolone resistance?

Author keywords

Beta lactam resistance; Fluoroquinolone resistance; Review; Tigecycline

Indexed keywords

AMPICILLIN; AZTREONAM; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; CEFEPIME; CEFOTAXIME; CEFOTETAN; CEFOXITIN; CEFPIROME; CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; CILASTATIN PLUS IMIPENEM; CIPROFLOXACIN; CLAVULANIC ACID; ERTAPENEM; IMIPENEM; MEROPENEM; METRONIDAZOLE; PENICILLIN DERIVATIVE; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SULBACTAM; SULTAMICILLIN; TAZOBACTAM; TIGECYCLINE; TIMENTIN; UNINDEXED DRUG;

EID: 33749541741     PISSN: 01634453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinf.2006.05.014     Document Type: Review
Times cited : (32)

References (64)
  • 1
    • 0025938759 scopus 로고
    • Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy
    • Chow J.W., Fine M.J., Shlaes D.M., Quinn J.P., Hooper D.C., Johnson M.P., et al. Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Ann Int Med 115 (1991) 585-590
    • (1991) Ann Int Med , vol.115 , pp. 585-590
    • Chow, J.W.1    Fine, M.J.2    Shlaes, D.M.3    Quinn, J.P.4    Hooper, D.C.5    Johnson, M.P.6
  • 2
    • 0023446047 scopus 로고
    • Health and economic impacts of antimicrobial resistance
    • Homberg S., Solomon S., and Blake P. Health and economic impacts of antimicrobial resistance. Rev infect Dis 9 (1987) 1065-1078
    • (1987) Rev infect Dis , vol.9 , pp. 1065-1078
    • Homberg, S.1    Solomon, S.2    Blake, P.3
  • 3
    • 0024614038 scopus 로고
    • Bug/drug resistance. Sometimes less is more
    • Phelps C. Bug/drug resistance. Sometimes less is more. Med Care 27 (1989) 194-203
    • (1989) Med Care , vol.27 , pp. 194-203
    • Phelps, C.1
  • 4
    • 0000982054 scopus 로고    scopus 로고
    • Antimicrobial agents: penicillins, cephalosporins, and other b-lactam antibiotics
    • Hardman J., et al. (Ed), McGraw-Hill, New York
    • Mandell G., and Perti W. Antimicrobial agents: penicillins, cephalosporins, and other b-lactam antibiotics. In: Hardman J., et al. (Ed). Goodman & Gilman's The Pharmacologic Basis of Therapeutics (1996), McGraw-Hill, New York 1073-1101
    • (1996) Goodman & Gilman's The Pharmacologic Basis of Therapeutics , pp. 1073-1101
    • Mandell, G.1    Perti, W.2
  • 5
    • 2942588985 scopus 로고    scopus 로고
    • Global dissemination of beta-lactamases mediating resistance to cephalosporins and carbapenems
    • Gootz T.D. Global dissemination of beta-lactamases mediating resistance to cephalosporins and carbapenems. Expert Rev Anti Infect Ther 2 2 (2004) 317-327
    • (2004) Expert Rev Anti Infect Ther , vol.2 , Issue.2 , pp. 317-327
    • Gootz, T.D.1
  • 6
    • 26944470372 scopus 로고    scopus 로고
    • SHV-type extended-spectrum beta-lactamase production is associated with reduced cefepime susceptibility in Enterobacter cloacae
    • Szabo D., Bonomo R.A., Silveira F., Pasculle A.W., Baxter C., Linden P.K., et al. SHV-type extended-spectrum beta-lactamase production is associated with reduced cefepime susceptibility in Enterobacter cloacae. J Clin Microbiol 43 10 (2005) 5058-5064
    • (2005) J Clin Microbiol , vol.43 , Issue.10 , pp. 5058-5064
    • Szabo, D.1    Bonomo, R.A.2    Silveira, F.3    Pasculle, A.W.4    Baxter, C.5    Linden, P.K.6
  • 7
    • 0018759356 scopus 로고
    • Emergence of resistance to cefamandole: possible role of cefoxitin-inducible beta-lactamases
    • Sanders C.C., and Sanders Jr. W.E. Emergence of resistance to cefamandole: possible role of cefoxitin-inducible beta-lactamases. Antimicrob Agents Chemother 15 6 (1979) 792-797
    • (1979) Antimicrob Agents Chemother , vol.15 , Issue.6 , pp. 792-797
    • Sanders, C.C.1    Sanders Jr., W.E.2
  • 8
    • 0020788109 scopus 로고
    • Emergence of resistance during therapy with the newer ß-lactam antibiotics: role of inducible ß-lactamases and implications for the future
    • Sanders C., and Sanders W.J. Emergence of resistance during therapy with the newer ß-lactam antibiotics: role of inducible ß-lactamases and implications for the future. Rev Infect Dis 5 (1983) 639-648
    • (1983) Rev Infect Dis , vol.5 , pp. 639-648
    • Sanders, C.1    Sanders, W.J.2
  • 9
    • 0026443767 scopus 로고
    • ß-lactam resistance in Gram-negative bacteria global trends and clinical impact
    • Sanders C., and Sanders W. ß-lactam resistance in Gram-negative bacteria global trends and clinical impact. Clin Infect Dis 15 (1992) 824-839
    • (1992) Clin Infect Dis , vol.15 , pp. 824-839
    • Sanders, C.1    Sanders, W.2
  • 10
    • 0025123862 scopus 로고
    • ß-lactam resistant Enterobacter bacteremia in febrile neutropenic patients receiving monotherapy
    • Johnson M., and Ramphal R. ß-lactam resistant Enterobacter bacteremia in febrile neutropenic patients receiving monotherapy. J Infect Dis 162 (1990) 981-983
    • (1990) J Infect Dis , vol.162 , pp. 981-983
    • Johnson, M.1    Ramphal, R.2
  • 11
    • 0028556586 scopus 로고
    • Development of resistance by Enterobacter cloacae during therapy of pulmonary infections in intensive care patients
    • Fussle R., Biscoping J., and Behr R. Development of resistance by Enterobacter cloacae during therapy of pulmonary infections in intensive care patients. Clin Invest 72 (1994) 1015-1019
    • (1994) Clin Invest , vol.72 , pp. 1015-1019
    • Fussle, R.1    Biscoping, J.2    Behr, R.3
  • 12
    • 0028063601 scopus 로고
    • Ceftazidime resistance among selected nosocomial gram-negative bacilli in the United States
    • Burwen D., Banerjee S., and Gaynes R. Ceftazidime resistance among selected nosocomial gram-negative bacilli in the United States. J Infect Dis 170 (1994) 1622-1625
    • (1994) J Infect Dis , vol.170 , pp. 1622-1625
    • Burwen, D.1    Banerjee, S.2    Gaynes, R.3
  • 13
    • 0031904174 scopus 로고    scopus 로고
    • Clinical problems posed by multiresistant non-fermenting gram-negative pathogens
    • Quinn J. Clinical problems posed by multiresistant non-fermenting gram-negative pathogens. Clin Infect Dis 27 (1998) S117-S124
    • (1998) Clin Infect Dis , vol.27
    • Quinn, J.1
  • 14
    • 0342651860 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of cefepime versus ceftazidime in ICU patients with hospital-acquired pneumonia
    • Ambrose P., Richerson M., and Bui K. Cost-effectiveness analysis of cefepime versus ceftazidime in ICU patients with hospital-acquired pneumonia. Clin Infect Dis 27 (1998) 1046
    • (1998) Clin Infect Dis , vol.27 , pp. 1046
    • Ambrose, P.1    Richerson, M.2    Bui, K.3
  • 15
    • 33645524091 scopus 로고    scopus 로고
    • Beta-lactamase inhibitors and new beta-lactamases
    • Paterson D. Beta-lactamase inhibitors and new beta-lactamases. Curr Treat Options Infect Dis 1 (1999) 85-87
    • (1999) Curr Treat Options Infect Dis , vol.1 , pp. 85-87
    • Paterson, D.1
  • 16
    • 0027981433 scopus 로고
    • Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus
    • Ito H., Yoshida H., Bogaki-Shonai M., Niga T., Hattori H., Nakamura S., et al. Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus. Antimicrob Agents Chemother 38 9 (1994) 2014-2023
    • (1994) Antimicrob Agents Chemother , vol.38 , Issue.9 , pp. 2014-2023
    • Ito, H.1    Yoshida, H.2    Bogaki-Shonai, M.3    Niga, T.4    Hattori, H.5    Nakamura, S.6
  • 17
    • 0028333874 scopus 로고
    • Characterization of fluoroquinolone-resistant mutants of Escherichia coli selected in vitro
    • Heisig P., and Tschorny R. Characterization of fluoroquinolone-resistant mutants of Escherichia coli selected in vitro. Antimicrob Agents Chemother 38 6 (1994) 1284-1291
    • (1994) Antimicrob Agents Chemother , vol.38 , Issue.6 , pp. 1284-1291
    • Heisig, P.1    Tschorny, R.2
  • 18
    • 0034285477 scopus 로고    scopus 로고
    • Recommendation for treatment of severe infections caused by Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs)
    • Paterson D.L. Recommendation for treatment of severe infections caused by Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs). Clin Microbiol Infect 6 9 (2000) 460-463
    • (2000) Clin Microbiol Infect , vol.6 , Issue.9 , pp. 460-463
    • Paterson, D.L.1
  • 19
    • 21444450013 scopus 로고    scopus 로고
    • Association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase VEB-1
    • Poirel L., Van De Loo M., Mammeri H., and Nordmann P. Association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase VEB-1. Antimicrob Agents Chemother 49 7 (2005) 3091-3094
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.7 , pp. 3091-3094
    • Poirel, L.1    Van De Loo, M.2    Mammeri, H.3    Nordmann, P.4
  • 20
    • 0036763320 scopus 로고    scopus 로고
    • The surgical infection society guidelines on antimicrobial therapy for intra-abdominal infections: an executive summary
    • Mazuski J., Sawyer R., and Nathens A.e.a. The surgical infection society guidelines on antimicrobial therapy for intra-abdominal infections: an executive summary. Surg Infect 3 (2002) 161-173
    • (2002) Surg Infect , vol.3 , pp. 161-173
    • Mazuski, J.1    Sawyer, R.2    Nathens, A.e.a.3
  • 21
    • 0142187282 scopus 로고    scopus 로고
    • Guidelines for the selection of anti-infective agent for complicated intra-abdominal infections
    • Solomkin J., Mazuski J., and Baron E.e.a. Guidelines for the selection of anti-infective agent for complicated intra-abdominal infections. Clin Inf Dis 37 (2003) 997-1005
    • (2003) Clin Inf Dis , vol.37 , pp. 997-1005
    • Solomkin, J.1    Mazuski, J.2    Baron, E.e.a.3
  • 24
    • 2342511642 scopus 로고    scopus 로고
    • Incidence of carbapenem-associated allergic-type reactions among patients with versus patients without a reported penicillin allergy
    • Prescott Jr. W.A., DePestel D.D., Ellis J.J., Regal R.E., et al. Incidence of carbapenem-associated allergic-type reactions among patients with versus patients without a reported penicillin allergy. Clin Infect Dis 38 8 (2004) 1102-1107
    • (2004) Clin Infect Dis , vol.38 , Issue.8 , pp. 1102-1107
    • Prescott Jr., W.A.1    DePestel, D.D.2    Ellis, J.J.3    Regal, R.E.4
  • 25
    • 33644793974 scopus 로고    scopus 로고
    • Optimal antibacterial treatment of uncomplicated skin and skin structure infections: applying a novel treatment algorithm
    • Elston D.M. Optimal antibacterial treatment of uncomplicated skin and skin structure infections: applying a novel treatment algorithm. J Drugs Dermatol 4 Suppl. 6 (2005) s15-s19
    • (2005) J Drugs Dermatol , vol.4 , Issue.SUPPL. 6
    • Elston, D.M.1
  • 26
    • 0348149161 scopus 로고    scopus 로고
    • Managing skin and soft tissue infections: expert panel recommendations on key decision points
    • Eron L.J., Lipsky B.A., Low D.E., Nathwani D., Tice A.D., Volturo G.A., et al. Managing skin and soft tissue infections: expert panel recommendations on key decision points. J Antimicrob Chemother 52 Suppl. 1 (2003) i3-i17
    • (2003) J Antimicrob Chemother , vol.52 , Issue.SUPPL. 1
    • Eron, L.J.1    Lipsky, B.A.2    Low, D.E.3    Nathwani, D.4    Tice, A.D.5    Volturo, G.A.6
  • 27
    • 1642395344 scopus 로고    scopus 로고
    • Beta-Lactam monotherapy versus beta-lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trials
    • Paul M., Benuri-Silbiger I., Soares-Weiser K., Leibovici L., et al. Beta-Lactam monotherapy versus beta-lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trials. BMJ 328 7441 (2004) 668
    • (2004) BMJ , vol.328 , Issue.7441 , pp. 668
    • Paul, M.1    Benuri-Silbiger, I.2    Soares-Weiser, K.3    Leibovici, L.4
  • 28
    • 0006884507 scopus 로고    scopus 로고
    • Efficacy of cefepime in the treatment of infections due to multiply resistant enterobacter species
    • Sanders W.J., Tenney J., and Kessler R. Efficacy of cefepime in the treatment of infections due to multiply resistant enterobacter species. Clin Infect Dis 23 (1996) 454-461
    • (1996) Clin Infect Dis , vol.23 , pp. 454-461
    • Sanders, W.J.1    Tenney, J.2    Kessler, R.3
  • 29
    • 0037115318 scopus 로고    scopus 로고
    • Clostridium difficile - associated diarrhea: epidemiological data from Western Australia associated with a modified antibiotic policy
    • Thomas C., et al. Clostridium difficile - associated diarrhea: epidemiological data from Western Australia associated with a modified antibiotic policy. Clin Infect Dis 35 12 (2002) 1457-1462
    • (2002) Clin Infect Dis , vol.35 , Issue.12 , pp. 1457-1462
    • Thomas, C.1
  • 30
    • 0023889192 scopus 로고
    • Synergistic interactions of ciprofloxacin and extended-spectrum ß-lactams or amino-glycosides against multiply drug-resistant Pseudomonas maltophilia
    • Chow A., Wong J., and Bartlett K. Synergistic interactions of ciprofloxacin and extended-spectrum ß-lactams or amino-glycosides against multiply drug-resistant Pseudomonas maltophilia. Antimicrob Agents Chemother 32 (1988) 782-784
    • (1988) Antimicrob Agents Chemother , vol.32 , pp. 782-784
    • Chow, A.1    Wong, J.2    Bartlett, K.3
  • 31
    • 0028287227 scopus 로고
    • Prospective randomized comparison of imipenem monotherapy with imipenem plus netilmicin for treatment of severe infections in non-neutropenic patients
    • Cometta A., Baumgartner J., and Lew D. Prospective randomized comparison of imipenem monotherapy with imipenem plus netilmicin for treatment of severe infections in non-neutropenic patients. Antimicrob Agents Chemother 38 (1994) 1309-1313
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1309-1313
    • Cometta, A.1    Baumgartner, J.2    Lew, D.3
  • 32
    • 0024350698 scopus 로고
    • Ciprofloxacin in combination with other antimicrobials
    • Eliopoulos G., and Eliopoulos C. Ciprofloxacin in combination with other antimicrobials. Am J Med 87 Suppl. 5A (1989) 17s-22s
    • (1989) Am J Med , vol.87 , Issue.SUPPL. 5A
    • Eliopoulos, G.1    Eliopoulos, C.2
  • 33
    • 0027251106 scopus 로고
    • Synergy and antagonism of fluoroquinolones with other classes of antimicrobial agents
    • Neu H. Synergy and antagonism of fluoroquinolones with other classes of antimicrobial agents. Drugs 45 Suppl. 3 (1993) 54-58
    • (1993) Drugs , vol.45 , Issue.SUPPL. 3 , pp. 54-58
    • Neu, H.1
  • 34
    • 0024213689 scopus 로고
    • Comparison of the bactericidal activity of ciprofloxacin alone and in combination with selected antipseudomonal beta-lactam agents against clinical isolates of Pseudomonas aeruginosa
    • Stratton C., Franke J., and Weeks L. Comparison of the bactericidal activity of ciprofloxacin alone and in combination with selected antipseudomonal beta-lactam agents against clinical isolates of Pseudomonas aeruginosa. Diagn Microbiol Infect Dis 11 (1989) 41-45
    • (1989) Diagn Microbiol Infect Dis , vol.11 , pp. 41-45
    • Stratton, C.1    Franke, J.2    Weeks, L.3
  • 35
    • 0036783671 scopus 로고    scopus 로고
    • Comparison of the in vitro activity of the glycylcycline tigecycline (formerly GAR-936) with those of tetracycline, minocycline, and doxycycline against isolates of non-tuberculous mycobacteria
    • Wallace Jr. R.J., Brown-Elliot B.A., Crist C.J., Wallace R.J., et al. Comparison of the in vitro activity of the glycylcycline tigecycline (formerly GAR-936) with those of tetracycline, minocycline, and doxycycline against isolates of non-tuberculous mycobacteria. Antimicrob Agents Chemother 46 10 (2002) 3164-3167
    • (2002) Antimicrob Agents Chemother , vol.46 , Issue.10 , pp. 3164-3167
    • Wallace Jr., R.J.1    Brown-Elliot, B.A.2    Crist, C.J.3    Wallace, R.J.4
  • 36
    • 0033843634 scopus 로고    scopus 로고
    • In vitro activity of GAR-936 against Chlamydia pneumoniae and Chlamydia trachomatis
    • Roblin P.M., and Hammerschlag M.R. In vitro activity of GAR-936 against Chlamydia pneumoniae and Chlamydia trachomatis. Int J Antimicrobial Agents 16 1 (2000) 61-63
    • (2000) Int J Antimicrobial Agents , vol.16 , Issue.1 , pp. 61-63
    • Roblin, P.M.1    Hammerschlag, M.R.2
  • 37
    • 0034863518 scopus 로고    scopus 로고
    • Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones
    • Kenny G.E., and Cartwright F.D. Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones. Antimicrob Agents Chemother 45 9 (2001) 2604-2608
    • (2001) Antimicrob Agents Chemother , vol.45 , Issue.9 , pp. 2604-2608
    • Kenny, G.E.1    Cartwright, F.D.2
  • 38
    • 0036175430 scopus 로고    scopus 로고
    • In vitro activity of 11 antimicrobial agents, including gatifloxacin and GAR936, tested against clinical isolates of Mycobacterium marinum
    • Rhomberg P.R., and Jones R.N. In vitro activity of 11 antimicrobial agents, including gatifloxacin and GAR936, tested against clinical isolates of Mycobacterium marinum. Diag Microbiol Infect Dis 42 2 (2002) 145-147
    • (2002) Diag Microbiol Infect Dis , vol.42 , Issue.2 , pp. 145-147
    • Rhomberg, P.R.1    Jones, R.N.2
  • 39
    • 0034158460 scopus 로고    scopus 로고
    • In-vitro susceptibility of anaerobic bacteria to GAR-936, a new glycylcycline
    • Edlund C., and Nord C.E. In-vitro susceptibility of anaerobic bacteria to GAR-936, a new glycylcycline. Clin Microbiol Infect 6 3 (2000) 159-163
    • (2000) Clin Microbiol Infect , vol.6 , Issue.3 , pp. 159-163
    • Edlund, C.1    Nord, C.E.2
  • 40
    • 0035991964 scopus 로고    scopus 로고
    • In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant gram-positive pathogens
    • Petersen P.J., Bradford P.A., Weiss W.J., Murphy T.M., Sum P.E., Projan S.J., et al. In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant gram-positive pathogens. Antimicrob Agents Chemother 46 8 (2002) 2595-2601
    • (2002) Antimicrob Agents Chemother , vol.46 , Issue.8 , pp. 2595-2601
    • Petersen, P.J.1    Bradford, P.A.2    Weiss, W.J.3    Murphy, T.M.4    Sum, P.E.5    Projan, S.J.6
  • 41
    • 0032918653 scopus 로고    scopus 로고
    • In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)
    • Petersen P.J., Jacobus N.V., Weiss W.J., Sum P.E., Testa R.T., et al. In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936). Antimicrob Agents Chemother 43 4 (1999) 738-744
    • (1999) Antimicrob Agents Chemother , vol.43 , Issue.4 , pp. 738-744
    • Petersen, P.J.1    Jacobus, N.V.2    Weiss, W.J.3    Sum, P.E.4    Testa, R.T.5
  • 42
    • 0033926236 scopus 로고    scopus 로고
    • In vitro activities of the glycylcycline GAR-936 against gram-positive bacteria
    • Boucher H.W., Wennersten C.B., and Eliopoulos G.M. In vitro activities of the glycylcycline GAR-936 against gram-positive bacteria. Antimicrob Agents Chemother 44 8 (2000) 2225-2229
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.8 , pp. 2225-2229
    • Boucher, H.W.1    Wennersten, C.B.2    Eliopoulos, G.M.3
  • 43
    • 0037764675 scopus 로고    scopus 로고
    • Antimicrobial resistance in Haemophilus influenzae and Moraxella catarrhalis respiratory tract isolates: results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002
    • Zhanel G.G., Palatnick L., Nichol K.A., Low D.E., Hoban D.J., et al. Antimicrobial resistance in Haemophilus influenzae and Moraxella catarrhalis respiratory tract isolates: results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002. Antimicrob Agents Chemother 47 6 (2003) 1875-1881
    • (2003) Antimicrob Agents Chemother , vol.47 , Issue.6 , pp. 1875-1881
    • Zhanel, G.G.1    Palatnick, L.2    Nichol, K.A.3    Low, D.E.4    Hoban, D.J.5
  • 44
    • 0034065855 scopus 로고    scopus 로고
    • Antipneumococcal activity of GAR 936, a new glycylcycline, compared to those of nine other agents against penicillin susceptible and resistant pneumococci
    • Hoellman D.B., Pankuch G.A., Jacobs M.R., Appelbaum P.C., et al. Antipneumococcal activity of GAR 936, a new glycylcycline, compared to those of nine other agents against penicillin susceptible and resistant pneumococci. Antimicrob Agents Chemother 44 4 (2000) 1085-1088
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.4 , pp. 1085-1088
    • Hoellman, D.B.1    Pankuch, G.A.2    Jacobs, M.R.3    Appelbaum, P.C.4
  • 45
    • 0033954848 scopus 로고    scopus 로고
    • Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1203 recent clinical bacterial isolates
    • Gales A.C., and Jones R.N. Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1203 recent clinical bacterial isolates. Diagn Microbiol Infect Dis 36 1 (2000) 19-36
    • (2000) Diagn Microbiol Infect Dis , vol.36 , Issue.1 , pp. 19-36
    • Gales, A.C.1    Jones, R.N.2
  • 46
    • 0038262639 scopus 로고    scopus 로고
    • In vitro activity of tigecycline (GAR-936), a novel glycylcycline, against vancomycin-resistant enterococci and staphylococci with diminished susceptibility to glycopeptides
    • Cercenado E.C.S.G.J.A.B.E. In vitro activity of tigecycline (GAR-936), a novel glycylcycline, against vancomycin-resistant enterococci and staphylococci with diminished susceptibility to glycopeptides. J Antimicrob Chemother 52 1 (2003) 138-139
    • (2003) J Antimicrob Chemother , vol.52 , Issue.1 , pp. 138-139
    • Cercenado, E.C.S.G.J.1
  • 47
    • 0033734720 scopus 로고    scopus 로고
    • Therapeutic efficacy of GAR-936, a novel glycylcycline, in a rat model of experimental endocarditis
    • Murphy T.M., Deitz J.M., Petersen P.J., Mikels S.M., Weiss W.J., et al. Therapeutic efficacy of GAR-936, a novel glycylcycline, in a rat model of experimental endocarditis. Antimicrob Agents Chemother 44 11 (2000) 3022-3027
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.11 , pp. 3022-3027
    • Murphy, T.M.1    Deitz, J.M.2    Petersen, P.J.3    Mikels, S.M.4    Weiss, W.J.5
  • 48
    • 0034075749 scopus 로고    scopus 로고
    • In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various gram-positive and gram-negative bacteria
    • van Ogtrop M.L., Andes D., Stamstad T.J., Conklin B., Weiss W.J., Craig W.A., et al. In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various gram-positive and gram-negative bacteria. Antimicrob Agents Chemother 44 4 (2000) 943-949
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.4 , pp. 943-949
    • van Ogtrop, M.L.1    Andes, D.2    Stamstad, T.J.3    Conklin, B.4    Weiss, W.J.5    Craig, W.A.6
  • 49
    • 0033818355 scopus 로고    scopus 로고
    • Preclinical pharmacology of GAR-936, a novel glycylcycline antibacterial agent
    • discussion 224S-228S
    • Projan S.J. Preclinical pharmacology of GAR-936, a novel glycylcycline antibacterial agent. Pharmacotherapy 20 9 Pt 2 (2000) 219S-223S discussion 224S-228S
    • (2000) Pharmacotherapy , vol.20 , Issue.9 PART 2
    • Projan, S.J.1
  • 50
    • 0036896559 scopus 로고    scopus 로고
    • Antimicrobial activity of tigecycline (GAR-936) against Enterococcus faecium and Staphylococcus aureus used alone and in combination
    • Mercier R.-C., Kennedy C., and Meadows C. Antimicrobial activity of tigecycline (GAR-936) against Enterococcus faecium and Staphylococcus aureus used alone and in combination. Pharmacotherapy 22 12 (2002) 1517-1523
    • (2002) Pharmacotherapy , vol.22 , Issue.12 , pp. 1517-1523
    • Mercier, R.-C.1    Kennedy, C.2    Meadows, C.3
  • 51
    • 28044443844 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, safety and tolerability of tigecycline
    • Rello J. Pharmacokinetics, pharmacodynamics, safety and tolerability of tigecycline. J Chemother 17 Suppl. 1 (2005) 12-22
    • (2005) J Chemother , vol.17 , Issue.SUPPL. 1 , pp. 12-22
    • Rello, J.1
  • 52
    • 28044451949 scopus 로고    scopus 로고
    • Efficacy of tigecycline in complicated skin and skin structure infections and complicated intra-abdominal infections
    • Wilcox M. Efficacy of tigecycline in complicated skin and skin structure infections and complicated intra-abdominal infections. J Chemother 17 Suppl. 1 (2005) 23-29
    • (2005) J Chemother , vol.17 , Issue.SUPPL. 1 , pp. 23-29
    • Wilcox, M.1
  • 53
    • 23844479577 scopus 로고    scopus 로고
    • The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: results of 2 double-blind phase 3 comparison studies with vancomycin-aztreonam
    • Ellis-Grosse E.J., Babinchak T., Dartois N., Rose G., Loh E., et al. The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: results of 2 double-blind phase 3 comparison studies with vancomycin-aztreonam. Clin Infect Dis 41 Suppl. 5 (2005) S341-S353
    • (2005) Clin Infect Dis , vol.41 , Issue.SUPPL. 5
    • Ellis-Grosse, E.J.1    Babinchak, T.2    Dartois, N.3    Rose, G.4    Loh, E.5
  • 54
    • 23944505501 scopus 로고    scopus 로고
    • Efficacy and safety of tigecycline monotherapy compared with vancomycin plus aztreonam in patients with complicated skin and skin structure infections: results from a phase 3, randomized, double-blind trial
    • Sacchidanand S., Penn R.L., Embil J.M., Campos M.E., Curcio D., Ellis-Grosse E., et al. Efficacy and safety of tigecycline monotherapy compared with vancomycin plus aztreonam in patients with complicated skin and skin structure infections: results from a phase 3, randomized, double-blind trial. Int J Infect Dis 9 5 (2005) 251-261
    • (2005) Int J Infect Dis , vol.9 , Issue.5 , pp. 251-261
    • Sacchidanand, S.1    Penn, R.L.2    Embil, J.M.3    Campos, M.E.4    Curcio, D.5    Ellis-Grosse, E.6
  • 55
    • 27144454645 scopus 로고    scopus 로고
    • Safety and efficacy of tigecycline in treatment of skin and skin structure infections: results of a double-blind phase 3 comparison study with vancomycin-aztreonam
    • Breedt J., Teras J., Gardovskis J., Maritz F.J., Vaasna T., Ross D.P., et al. Safety and efficacy of tigecycline in treatment of skin and skin structure infections: results of a double-blind phase 3 comparison study with vancomycin-aztreonam. Antimicrob Agents Chemother 49 11 (2005) 4658-4666
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.11 , pp. 4658-4666
    • Breedt, J.1    Teras, J.2    Gardovskis, J.3    Maritz, F.J.4    Vaasna, T.5    Ross, D.P.6
  • 56
    • 23844486729 scopus 로고    scopus 로고
    • The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial data
    • Babinchak T., Ellis-Grosse E., Dartois N., Rose G.M.., Loh E., et al. The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial data. Clin Infect Dis 41 Suppl. 5 (2005) S354-S367
    • (2005) Clin Infect Dis , vol.41 , Issue.SUPPL. 5
    • Babinchak, T.1    Ellis-Grosse, E.2    Dartois, N.3    Rose, G.M..4    Loh, E.5
  • 57
    • 23244467895 scopus 로고    scopus 로고
    • Tigecycline is efficacious in the treatment of complicated intra-abdominal infections
    • Fomin P., Bouran M., Gradauskas A., Barauskas G., Datsenko A., Dartois N., et al. Tigecycline is efficacious in the treatment of complicated intra-abdominal infections. Int J Surg 3 1 (2005) 35-47
    • (2005) Int J Surg , vol.3 , Issue.1 , pp. 35-47
    • Fomin, P.1    Bouran, M.2    Gradauskas, A.3    Barauskas, G.4    Datsenko, A.5    Dartois, N.6
  • 58
    • 27744520632 scopus 로고    scopus 로고
    • A multicenter trial of the efficacy and safety of tigecycline versus imipenem/cilastatin in patients with complicated intra-abdominal infections [Study ID Numbers: 3074A1-301-WW; ClinicalTrials.gov Identifier: NCT00081744]
    • Oliva M.E., Rekha A., Yellin A., Pasternak J., Campos M., Rose G.M., et al. A multicenter trial of the efficacy and safety of tigecycline versus imipenem/cilastatin in patients with complicated intra-abdominal infections [Study ID Numbers: 3074A1-301-WW; ClinicalTrials.gov Identifier: NCT00081744]. BMC Infect Dis 5 (2005) 88
    • (2005) BMC Infect Dis , vol.5 , pp. 88
    • Oliva, M.E.1    Rekha, A.2    Yellin, A.3    Pasternak, J.4    Campos, M.5    Rose, G.M.6
  • 59
    • 0037229072 scopus 로고    scopus 로고
    • Activities of the glycylcycline tigecycline (GAR-936) against 1924 recent European clinical bacterial isolates
    • Milatovic D., Schmitz F.-J., Verhoef J., Fluit A.C., et al. Activities of the glycylcycline tigecycline (GAR-936) against 1924 recent European clinical bacterial isolates. Antimicrob Agents Chemother 47 1 (2003) 400-404
    • (2003) Antimicrob Agents Chemother , vol.47 , Issue.1 , pp. 400-404
    • Milatovic, D.1    Schmitz, F.-J.2    Verhoef, J.3    Fluit, A.C.4
  • 60
    • 0038262639 scopus 로고    scopus 로고
    • In vitro activity of tigecycline (GAR-936), a novel glycylcycline, against vancomycin-resistant enterococci and staphylococci with diminished susceptibility to glycopeptides
    • Cercenado E., Cercenado S., Gomez J.A., Bouza E., et al. In vitro activity of tigecycline (GAR-936), a novel glycylcycline, against vancomycin-resistant enterococci and staphylococci with diminished susceptibility to glycopeptides. J Antimicrob Chemother 52 1 (2003) 138-139
    • (2003) J Antimicrob Chemother , vol.52 , Issue.1 , pp. 138-139
    • Cercenado, E.1    Cercenado, S.2    Gomez, J.A.3    Bouza, E.4
  • 61
    • 0038441345 scopus 로고    scopus 로고
    • Antimicrobial resistance in respiratory tract Streptococcus pneumoniae isolates: results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002
    • Zhanel G.G., Palatnick L., Nichol K.A., Bellyou T., Low D.E., Hoban D.J., et al. Antimicrobial resistance in respiratory tract Streptococcus pneumoniae isolates: results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002. Antimicrob Agents Chemother 47 6 (2003) 1867-1874
    • (2003) Antimicrob Agents Chemother , vol.47 , Issue.6 , pp. 1867-1874
    • Zhanel, G.G.1    Palatnick, L.2    Nichol, K.A.3    Bellyou, T.4    Low, D.E.5    Hoban, D.J.6
  • 62
    • 0036167886 scopus 로고    scopus 로고
    • In vitro activities of tigecycline (GAR-936) against recently isolated clinical bacteria in Spain
    • Spanish Group of Tigecycline
    • Betriu C., Rodriguez-Avial I., Sanchez B.A., Gomez M., Alvarez J., Picazo J.J., and Spanish Group of Tigecycline. In vitro activities of tigecycline (GAR-936) against recently isolated clinical bacteria in Spain. Antimicrob Agents Chemother 46 3 (2002) 892-895
    • (2002) Antimicrob Agents Chemother , vol.46 , Issue.3 , pp. 892-895
    • Betriu, C.1    Rodriguez-Avial, I.2    Sanchez, B.A.3    Gomez, M.4    Alvarez, J.5    Picazo, J.J.6
  • 63
    • 2942571341 scopus 로고    scopus 로고
    • Results of a multicenter, randomized, open-label efficacy and safety study of two doses of tigecycline for complicated skin and skin-structure infections in hospitalized patients
    • Postier G., Green S.L., Klein S.R., Ellis-Grosse E.J., and Loh E. Results of a multicenter, randomized, open-label efficacy and safety study of two doses of tigecycline for complicated skin and skin-structure infections in hospitalized patients. Clin Ther 26 5 (2004) 704-714
    • (2004) Clin Ther , vol.26 , Issue.5 , pp. 704-714
    • Postier, G.1    Green, S.L.2    Klein, S.R.3    Ellis-Grosse, E.J.4    Loh, E.5
  • 64
    • 0346452266 scopus 로고    scopus 로고
    • The clinical response to tigecycline in the treatment of complicated intra-abdominal infections in hospitalized patients. A phase 2 clinical trial
    • Murray J., Wilson S., Klein S., Yellin A., Loh E., et al. The clinical response to tigecycline in the treatment of complicated intra-abdominal infections in hospitalized patients. A phase 2 clinical trial. Abstr 43rd Intersci Conf Antimicrob Agents Chemother 43 (2003) 416
    • (2003) Abstr 43rd Intersci Conf Antimicrob Agents Chemother , vol.43 , pp. 416
    • Murray, J.1    Wilson, S.2    Klein, S.3    Yellin, A.4    Loh, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.