Thioguanine versus mercaptopurine in childhood ALL

Lancet

Volumn 368, Issue 9544, 2006, Pages 1304-1306

  Stanulla, Martin ^a   Schünemann, Holger J ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; MERCAPTOPURINE; PREDNISOLONE; TIOGUANINE;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ACUTE LYMPHOBLASTIC LEUKEMIA; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CANCER RELAPSE; CANCER SURVIVAL; CLINICAL TRIAL; COMPARATIVE STUDY; CONFIDENCE INTERVAL; DOSE RESPONSE; DRUG EFFICACY; HEPATOMEGALY; HUMAN; HYPERBILIRUBINEMIA; LEUKOPENIA; LIVER TOXICITY; LIVER VENOOCCLUSIVE DISEASE; PORTAL HYPERTENSION; PRIORITY JOURNAL; RISK ASSESSMENT; SURVIVAL RATE; SURVIVAL TIME; THROMBOCYTOPENIA; TREATMENT OUTCOME;

EID: 33749532466     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(06)69531-7     Document Type: Note

References (12)

1. Pui C., and Evans W. Treatment of childhood acute lymphoblastic leukemia. N Engl J Med 354 (2006) 166-178
2. Schrappe M., Reiter A., Zimmermann M., et al. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Leukemia 14 (2000) 2205-2222
3. Vora A., Mitchell C., Lennard L., et al., for the Medical Research Council/National Cancer Research Network Childhood Leukaemia Working Party. Toxicity and efficacy of thioguanine versus mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. Lancet 368 (2006) 1339-1348
4. Elion G., Burgi E., and Hitchings G. Studies on condensed pyrimidine systems. IX: the synthesis of some 6-substituted purines. J Am Chem Soc 74 (1952) 411-414
5. Burchenal J., Murphy M., Ellison R., et al. Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases. Blood 8 (1953) 965-999
6. Harms D., Göbel U., Spaar H., et al. Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: results of the randomized trial COALL-92. Blood 102 (2003) 2736-2740
7. Stork L., Sather H., Hutchinson R., et al. Comparison of mercaptopurine (MP) with thioguanine (TG) and IT methotrexate (ITM) with IT "triples" (ITT) in children with SR-ALL: results of CCG-1952. Blood 100 (2002) 156
8. de Boer N., Reinisch W., Teml A., et al. 6-Thioguanine treatment in inflammatory bowel disease: a critical appraisal by a European 6-TG working party. Digestion 73 (2006) 25-31
9. Oxman A., and Guyatt G. A consumer's guide to subgroup analyses. Ann Intern Med 116 (1992) 78-84
10. Mitchell C., Richards S., Kinsey S., Lilleyman J., Vora A., and Eden T. Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial. Br J Haematol 129 (2005) 734-745
11. Montori V., Devereaux P., Adhikari N., et al. Randomized trials stopped early for benefit: a systematic review. JAMA 294 (2005) 2203-2209
12. McAlister F., Straus S., Sackett D., and Altman D. Analysis and reporting of factorial trials: a systematic review. JAMA 289 (2003) 2545-2553