Muscle fatigue: Lactic acid or inorganic phosphate the major cause?

News in Physiological Sciences

Volumn 17, Issue 1, 2002, Pages 17-21

  Westerblad, Håkan ^a   Allen, David G ^a   Lännergren, Jan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; LACTIC ACID; PHOSPHATE; PHOSPHORYLASE;

ACIDIFICATION; ACIDOSIS; ARTICLE; CALCIUM TRANSPORT; ENERGY METABOLISM; HUMAN; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE FUNCTION; NONHUMAN; PRECIPITATION; SKELETAL MUSCLE; TEMPERATURE;

EID: 0036462412     PISSN: 08861714     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiologyonline.2002.17.1.17     Document Type: Article

References (20)

1. 2+-activated anion channel in sarcoplasmic reticulum of skeletal muscle
2. Muscle cell function during prolonged activity: Cellular mechanisms of fatigue
3. 2+ release channel
4. Effect of muscle acidity on muscle metabolism and fatigue during intense exercise in man
5. 2-induced acidification on the fatigue resistance of single mouse muscle fibers at 28°C
6. Role of myoplasmic phosphate in contractile function of skeletal muscle: Studies on creatine kinase-deficient mice
7. Is creatine kinase responsible for fatigue? Studies of skeletal muscle deficient of creatine kinase
8. i in mouse skeletal muscle
9. 2+ efflux from the SR in mechanically skinned rat skeletal muscle fibers
10. 2+ movements and tension development in rat skinned skeletal muscle fibres
11. The role of calcium stores in fatigue of isolated single muscle fibres from the cane toad
12. The use of fluo-5N to measure sarcoplasmic reticulum calcium in single muscle fibres of the cane toad
13. Effect of myoplasmic pH on excitation-contraction coupling in skeletal muscle fibres of the toad
14. Reduced effect of pH on skinned rabbit psoas muscle mechanics at high temperatures: Implications for fatigue
15. The effect of metabolic fuel on force production and resting inorganic phosphate levels in mouse skeletal muscle
16. L(+)-lactate does not affect twitch and tetanic responses in mechanically skinned mammalian muscle fibres
17. Effects of acidosis on tension development in mammalian skeletal muscle
18. Relationship of contraction capacity to metabolic changes during recovery from a fatiguing contraction
19. The effect of intracellular pH on contractile function of intact, single fibres of mouse muscle declines with increasing temperature
20. Effect of intracellular pH on force development depends on temperature in intact skeletal muscle from mouse