Endothelium-dependent induction of vasorelaxation by the butanol extract of Phellinus igniarius in isolated rat aorta

American Journal of Chinese Medicine

Volumn 34, Issue 4, 2006, Pages 655-665

  Kang, Dae Gill ^a,b   Cao, Li Hua ^a   Lee, Jun Kyoung ^a   Choi, Deok Ho ^a   Kim, Seung Ju ^a   Lee, Hyuck ^a   Kim, Jin Sook ^c   Lee, Ho Sub ^a,b  

^a Wonkwang University   (South Korea)

^b Wonkwang University   (South Korea)

^c Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Butanol extract of Phellinus igniarius (BPI); L type Ca2+ channels; NO cGMP; Vascular relaxation

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ATROPINE; BUTANOL; CALCIUM CHANNEL L TYPE; CYCLIC GMP; DILTIAZEM; GLIBENCLAMIDE; INDOMETACIN; METHYLENE BLUE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHELLINUS IGNIARIUS EXTRACT; PHENYLEPHRINE; PLANT EXTRACT; PROPRANOLOL; TETRYLAMMONIUM; UNCLASSIFIED DRUG; VERAPAMIL;

AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM; ISOLATED ARTERY; NONHUMAN; POLYPORACEAE; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; AORTA; ATROPINE; BUTANOLS; CYCLIC GMP; DILTIAZEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GLYBURIDE; INDOMETHACIN; MALE; METHYLENE BLUE; NG-NITROARGININE METHYL ESTER; OXADIAZOLES; POLYPORACEAE; PROPRANOLOL; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; TETRAETHYLAMMONIUM; VASODILATION; VASODILATOR AGENTS; VERAPAMIL;

EID: 33749470648     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X06004181     Document Type: Article

References (34)

1. Ahluwalia, A., P. Foster, R.S. Scotland, P.G. McLean, A. Mathur, M. Perretti, S. Moncada and A.J. Hobbs. Antiinflammatory activity of soluble guanylate cyclase: CGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc. Natl. Acad. Sci. USA 101: 1386-1391, 2004.
2. Bradford, M.M. A rapid and sensitive method for the quanititation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72: 248-254, 1976.
3. Busse, R. and I. Fleming. Endothelial dysfunction in atherosclerosis. J. Vasc. Res. 33: 181-194, 1996.
4. Cartwright, J.E., G.S. Whitley and A.P. Johnstone. Endothelial cell adhesion molecule expression and lymphocyte adhesion to endothelial cells: Effect of nitric oxide. Exp. Cell Res. 235: 431-434, 1997.
5. Chen, Z.Y., Z.S. Zhang, K.Y. Kwan, M. Zhu, W.K.K. Ho and Y. Huang. Endothelium-dependent relaxation induced by hawthorn extract in rat mesenteric artery. Life Sci. 63: 1983-1991, 1998.
6. Chiou, W.F., P.C. Chang, C.J. Chou and C.F. Chen. Protein constituents to the hypotensive and vasorelaxant activities of Cordyceps sinensis. Life Sci. 66: 1369-1376, 2000.
7. Cohen, R.A. The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. Prog. Cardiovascul. Dis. 38: 105-128, 1995.
8. Egashira, K., T. Inou, Y. Hirooka, H. Kai, M. Sugimachi, S. Suzuki, T. Kuga, Y. Urabe and A. Takeshita. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine. Circulation 88: 77-81, 1993.
9. Furchgott, R.F. and J.V. Zawadzki. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376, 1980.
10. Gordon, J.L. and W. Martin. Stimulation of endothelial prostacyclin production plays no role in endothelium-dependent relaxation of the pig aorta. Brit. J. Pharmacol. 80: 179-186, 1983.
11. Kamata, K., M. Noguchi and M. Nagai. Hypotensive effects of lithospermic acid B isolated from the extract of Salviae miltiorrhiza radix in the rat. Gen. Pharmacol. 25: 69-73, 1994.
12. Kang, D.G., J.K. Lee, D.H. Choi, E.J. Sohn, M.K. Moon and H.S. Lee. Vascular relaxation by the methanol extract of Sorbus cortex via NO-cGMP pathway. Biol. Pharm. Bull. 28: 860-864, 2005.
13. Kang, D.G., T.Y. Hur, G.M. Lee, H. Oh, T.O. Kwon, E.J. Sohn and H.S. Lee. Effects of Cudrania tricuspidata water extract on blood pressure and renal functions in NO-dependent hypertension. Life Sci. 70: 2599-2609, 2002a.
14. Kang, D.G., H. Oh, D.K. Cho, E.K. Kwon, J.H. Han and H.S. Lee. Effects of bulb of Fritillaria ussuriensis MAXIM on angiotensin converting enzyme and vascular release of NO/cGMP in rats. J. Ethnopharmacol. 81: 49-55, 2002b.
15. Kim, S.H., K.W. Kang, K.W. Kim and N.D. Kim Procyanidins in Crataegus extract evoke endothelium-dependent vasorelacation in rat aorta. Life Sci. 67: 121-131, 2000.
16. Kim, S.Z., S.H. Kim, J.K. Park, G.Y. Koh and K.W. Cho. Presence and biological activity of C-type natriuretic peptide-dependent guanylate cyclase-coupled receptor in the penile corpus cavernosum. J. Urol. 159: 1741-1746, 1998.
17. Kuramochi, T., J. Chu and T. Suga. Gou-teng (from Uncaria rhynchophylla MIQUEL)-induced endothelium-dependent andindependent relaxations in the isolated rat aorta. Life Sci. 54: 2061-2069, 1994.
18. Loeb, A.L., N.J. Jr. Izzo, R.M. Johnson, J.C. Garrison and M.J. Peach. Endothelium-derived relaxing factor release associated with increased endothelial cell inositol trisphosphate and intracellular calcium. Am. J. Cardiol. 62: 36G-40G, 1988.
19. Loscarzo, J. and G. Welch. Nitric oxide and its role in the cardiovascular system. Prog. Cardiovasc. Dis. 38: 87-104, 1995.
20. Luscher, T.F. and P.M. Vanhoutte. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension 8: 344-348, 1986.
21. Mo, S., S. Wang, G. Zhou, Y. Yang, Y. Li, X. Chen and J. Shi. Phelligridins C-F: Cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius. J. Nat. Prod. 67: 823-828, 2004.
22. Mo, S.Y., Y.C. Yang and J.G. Shi. Studies on chemical constitutes of Phellinus igniarius. Zhongguo Zhong Yao Za Zhi. 28: 339-341, 2003.
23. Murad, F., Cyclic guanosine monophosphate as a mediator of vasodilatoon. J. Clin. Invest. 78: 1-5, 1986.
24. Rapoport, R.M., M.B. Draznin and F. Murad. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 306: 174-176, 1983.
25. Satake, N., S. Kiyoto, S. Shibata, V. Gandhi, D.J. Jones and M. Morikawa. Possible mechanisms of inhibition with atropine against noradrenaline-induced contraction in the rabbit aorta. Brit. J. Pharmacol. 107: 553-538, 1992.
26. Sato, K., H. Ozaki and H. Karaki. Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2. J. Pharmacol. Exp. Ther. 246: 294-300, 1988.
27. Shon, Y.H. and K.S. Nam. Antimutagenicity and induction of anticarcinogenic phase II enzymes by basidiomycetes. J. Ethnopharmacol. 77(1): 103-109, 2001.
28. Standen, N.B., J.M. Quayle, N.W. Davies, J.E. Brayden, Y. Huang and M.T. Nelson. Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle. Science 245: 177-180, 1989.
29. Tanner, M.A., X. Bu, J.A. Steimle and P.R. Myers. The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum. Nitric Oxide 3: 359-365, 1999.
30. Vallance, P., J. Collier and S. Moncada. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2: 997-1000, 1989.
31. Wang, Y., S.Y. Mo, S.J. Wang, S. Li, Y.C. Yang and J.G. Shi. A unique highly oxygenated pyrano[4,3-c][2]benzopyran-1,6-dione derivative with antioxidant and cytotoxic activities from the fungus Phellinus igniarius. Org. Lett. 7: 1675-1678, 2005.
32. Xie, Y.W., D.S. Ming, H.X. Xu, H. Dong and P.P.H. But. Vasorelaxing effects of Caesalpinia sappan involvement endogenous nitric oxide. Life Sci. 67: 1913-1918, 2000.
33. Yin, M.H., D.G. Kang, D.H. Choi, T.O. Kwon and H.S. Lee. Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines. J. Ethnopharmacol. 99: 113-117, 2005.
34. Zeiher, A.M., H. Drexler, B. Saurbier and H. Just. Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J. Clin. Invest. 92: 652-662, 1993.