Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia

American Journal of Psychiatry

Volumn 163, Issue 10, 2006, Pages 1829-1831

  Paz, Rodrigo D ^b   Andreasen, Nancy C ^b   Daoud, Sami Z ^b   Conley, Robert ^b   Roberts, Rosalinda ^b   Bustillo, Juan ^b   Perrone Bizzozero, Nora I ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMIC ACID; HALOPERIDOL; MESSENGER RNA; NEUROMODULIN; RECEPTOR SUBUNIT;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL FUNCTION; CEREBELLUM CORTEX; CONTROLLED STUDY; DRUG EXPOSURE; FEMALE; GENE; GENE EXPRESSION; GRANULE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCHIZOPHRENIA;

EID: 33749459988     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.2006.163.10.1829     Document Type: Article

References (10)

1. Kim JJ, Mohamed S, Andreasen NC, O'Leary DS, Watkins GL, Boles Ponto LL, Hichwa RD: Regional neural dysfunctions in chronic schizophrenia studied with positron emission tomography. Am J Psychiatry 2000; 157:542-548
2. Potkin SG, Alva G, Fleming K, Anand R, Keator D, Carreon D, Doo M, Jin Y, Wu JC, Fallon JH: A PET study of the pathophysiology of negative symptoms in schizophrenia. Am J Psychiatry 2002; 159:227-237
3. Malaspina D, Harkavy-Friedman J, Corcoran C, Mujica-Parodi L, Printz D, Gorman JM, Van Heertum R: Resting neural activity distinguishes subgroups of schizophrenia patients. Biol Psychiatry 2004; 56:931-937
4. Laurie DJ, Seeburg PH, Wisden W: The distribution of 13 GABAA receptor subunit mRNAs in the rat brain, II: olfactory bulb and cerebellum. J Neurosci 1992; 12:1063-1076
5. Higo N, Oishi T, Yamashita A, Matsuda K, Hayashi M: Cell type- and region-specific expression of protein kinase C-substrate mRNAs in the cerebellum of the macaque monkey. J Comp Neurol 2003; 467:135-149
6. Cantallops I, Routtenberg A: Activity-dependent regulation of axonal growth: posttranscriptional control of the GAP-43 gene by the NMDA receptor in developing hippocampus. J Neurobiol 1999; 41:208-220
7. Gault LM, Siegel RE: Expression of the GABAA receptor delta subunit is selectively modulated by depolarization in cultured rat cerebellar granule neurons. J Neurosci 1997; 17:2391-2399
8. ΔΔCT method. Methods 2001; 25:402-408
9. Chadderton P, Margrie TW, Hausser M: Integration of quanta in cerebellar granule cells during sensory processing. Nature 2004; 428:856-860
10. Ho BC, Mola C, Andreasen NC: Cerebellar dysfunction in neuroleptic naive schizophrenia patients: clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs. Biol Psychiatry 2004; 55:1146-1153