Cytochrome P450 2E1/2A6-selective inhibition by halogenated anilines on metabolic activation of dimethylnitrosamine in human liver microsomes

Journal of Health Science

Volumn 52, Issue 5, 2006, Pages 623-627

  Ohashi, Yohei ^a   Kato, Taka Aki ^a   Yamada, Katsuya ^a   Mizutani, Takaharu ^a   Saeki, Ken Ichi ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Alkylnitrosamine; Carcinogenicity; Cytochrome P450 2E1; Halogen substitution; Inhibitor

Indexed keywords

2,3,4 TRICHLOROANILINE; 2,6 DIBROMOANILINE; 3,4,5 TRIFLUOROANILINE; 3,5 DICHLOROANILINE; ANILINE DERIVATIVE; BROMOANILINE DERIVATIVE; CHLOROANILINE DERIVATIVE; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2E1; DIMETHYLNITROSAMINE; FLUROANILINE DERIVATIVE; HALOGEN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN EXPERIMENT; HYDROXYLATION; LIVER MICROSOME; METABOLISM; SUBSTITUTION REACTION;

EID: 33749444000     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.52.623     Document Type: Article

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