The human metapneumovirus: Biology, epidemiological features, and clinical characteristics of infection

Reviews and Research in Medical Microbiology

Volumn 17, Issue 1, 2006, Pages 11-25

  Schildgen, Oliver ^a,b   Simon, Arne ^b   Wilkesmann, Anja ^b   Williams, John ^c   Eis Hübinger, Anna Maria ^a   Kupfer, Bernd ^a   Roggendorf, Michael ^d   Viazov, Sergei ^d  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

HMPV; Human Metapneumovirus; Paramyxoviruses; Respiratory viruses

Indexed keywords

ADRENALIN; ANTIBIOTIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; FAS ASSOCIATED DEATH DOMAIN PROTEIN; GLYCOPROTEIN; IMMUNOGLOBULIN; LIVER ENZYME; MONOCLONAL ANTIBODY; PALIVIZUMAB; RIBAVIRIN; STEROID; VIRUS RNA; VIRUS VACCINE; VIRUS VECTOR;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ACUTE RESPIRATORY TRACT DISEASE; ASTHMA; BACTERIAL INFECTION; BRONCHIOLITIS; BRONCHITIS; CLINICAL FEATURE; DATA ANALYSIS; DIARRHEA; DISEASE COURSE; DISEASE EXACERBATION; ENCEPHALITIS; GENETIC VARIABILITY; GENETICS; GENOME ANALYSIS; HAMSTER; HOSPITAL INFECTION; HOSPITALIZATION; HUMAN; IMMUNE DEFICIENCY; IMMUNITY; LABORATORY TEST; METAPNEUMOVIRUS; NONHUMAN; PATHOGENESIS; PNEUMONIA; POLYMERASE CHAIN REACTION; PRIMATE; PRIORITY JOURNAL; RADIOGRAPHY; RASH; REVIEW; RISK ASSESSMENT; VIRUS CULTURE; VIRUS DETECTION; VIRUS IMMUNITY; VIRUS INFECTION; VIRUS ISOLATION; WILD TYPE;

EID: 33749435196     PISSN: 0954139X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.revmedmi.0000237165.94641.c1     Document Type: Review

References (160)

1. Erker JC, Simons JN, Muerhoff AS, Leary TP, Chalmers ML, Desai SM, et al. Molecular cloning and characterization of a GB virus C isolate from a patient with non-A-E hepatitis. J Gen Virol 1996; 77:2713-2720.
2. Biagini P. Human circoviruses. Vet Microbiol 2004; 98:95-101.
3. van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 2001; 7:719-724.
4. Drosten C, Gunther S, Preiser W, van der WS, Brodt HR, Becker S, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Eng J Med 2003; 348:1967-1976.
5. van der Hoek L, Pyrc K, Jebbink MF, Vermeulen-Oost W, Berkhout RJ, Wolthers KC, et al. Identification of a new human coronavirus. Nat Med 2004; 10:368-373.
6. Fouchier RA, Hartwig NG, Bestebroer TM, Niemeyer B, de Jong JC, Simon JH, et al. A previously undescribed coronavirus associated with respiratory disease in humans. Proc Natl Acad Sci USA 2004; 101:6212-6216.
7. Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci USA 2005; 102:12891-12896.
8. Jones MS, Kapoor A, Lukashov VV, Simmonds P, Hecht F, Delwart E. New DNA viruses identified in patients with acute viral infection syndrome. J Virol 2005; 79:8230-8236.
9. Crowe JE Jr. Human metapneumovirus as a major cause of human respiratory tract disease. Pediatr Infect Dis J 2004; 23:S215-S221.
10. Fouchier RA, Rimmelzwaan GF, Kuiken T, Osterhaus AD. Newer respiratory virus infections: human metapneumovirus, avian influenza virus, and human coronaviruses. Curr Opin Infect Dis 2005; 18:141-146.
11. Hamelin ME, Abed Y, Boivin G. Human metapneumovirus: a new player among respiratory viruses. Clin Infect Dis 2004; 38:983-990.
12. Mahalingam S, Schwarze J, Zaid A, Nissen M, Sloots T, Tauro S, et al. Perspective on the host response to human metapneumovirus infection: what can we learn from respiratory syncytial virus infections? Microbes Infect 2005; 8:285-293.
13. van den Hoogen BG, Osterhaus DM, Fouchier RA. Clinical impact and diagnosis of human metapneumovirus infection. Pediatr Infect Dis J 2004; 23:S25-S32.
14. Biacchesi S, Skiadopoulos MH, Boivin G, Hanson CT, Murphy BR, Collins PL, et al. Genetic diversity between human metapneumovirus subgroups. Virology 2003; 315:1-9.
15. van den Hoogen BG, Bestebroer TM, Osterhaus AD, Fouchier RA. Analysis of the genomic sequence of a human metapneumovirus. Virology 2002; 295:119-132.
16. Lwamba HC, Alvarez R, Wise MG, Yu Q, Halvorson D, Njenga MK, et al. Comparison of the full-length genome sequence of avian metapneumovirus subtype C with other paramyxoviruses. Virus Res 2005; 107:83-92.
17. van denHoogen BG, Herfst S, Sprong L, Cane PA, Forleo-Neto E, de Swart RL, et al. Antigenic and genetic variability of human metapneumoviruses. Emerg Infect Dis 2004; 10:658-666.
18. Herfst S, de Graaf M, Schickli JH, Tang RS, Kaur J, Yang CF, et al. Recovery of human metapneumovirus genetic lineages a and B from cloned cDNA. J Virol 2004; 78:8264-8270.
19. Zimmer G, Bossow S, Kolesnikova L, Hinz M, Neubert WJ, Herrler G. A chimeric respiratory syncytial virus fusion protein functionally replaces the F and HN glycoproteins in recombinant Sendai virus. J Virol 2005; 79:10467-10477.
20. Ma X, Endo R, Ebihara T, Ishiguro N, Ishiko H, Kikuta H. Production and characterization of neutralizing monoclonal antibodies against human metapneumovirus F protein. Hybridoma (Larchmt) 2005; 24:201-205.
21. Skiadopoulos MH, Biacchesi S, Buchholz UJ, Riggs JM, Surman SR, Amaro-Carambot E, et al. The two major human metapneumovirus genetic lineages are highly related antigenically, and the fusion (F) protein is a major contributor to this antigenic relatedness. J Virol 2004; 78:6927-6937.
22. Tang RS, Schickli JH, Macphail M, Fernandes F, Bicha L, Spaete J, et al. Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3′ proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity. J Virol 2003; 77:10819-10828.
23. Bastien N, Liu L, Ward D, Taylor T, Li Y. Genetic variability of the G glycoprotein gene of human metapneumovirus. J Clin Microbiol 2004; 42:3532-3537.
24. Ishiguro N, Ebihara T, Endo R, Ma X, Kikuta H, Ishiko H, et al. High genetic diversity of the attachment (G) protein of human metapneumovirus. J Clin Microbiol 2004; 42:3406-3414.
25. Peret TC, Abed Y, Anderson LJ, Erdman DD, Boivin G. Sequence polymorphism of the predicted human metapneumovirus G glycoprotein. J Gen Virol 2004; 85:679-686.
26. Biacchesi S, Pham QN, Skiadopoulos MH, Murphy BR, Collins PL, Buchholz UJ. Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. J Virol 2005; 79:12608-12613.
27. Biacchesi S, Skiadopoulos MH, Tran KC, Murphy BR, Collins PL, Buchholz UJ. Recovery of human metapneumovirus from cDNA: optimization of growth in vitro and expression of additional genes. Virology 2004; 321:247-259.
28. Bermingham A, Collins PL. The M2-2 protein of human respiratory syncytial virus is a regulatory factor involved in the balance between RNA replication and transcription. Proc Natl Acad Sci USA 1999; 96:11259-11264.
29. Buchholz UJ, Biacchesi S, Pham QN, Tran KC, Yang L, Luongo CL, et al. Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity. J Virol 2005; 79:6588-6597.
30. Schildgen O, Geikowski T, Glatzel T, Simon A, Wilkesmann A, Roggendorf M, et al. New variant of the human metapneumovirus (hMPV) associated with an acute and severe exacerbation of asthma bronchiale. J Clin Virol 2004; 31:283-288.
31. Bastien N, Normand S, Taylor T, Ward D, Peret TC, Boivin G, et al. Sequence analysis of the N, P. M and F genes of Canadian human metapneumovirus strains Virus Res 2003; 93:51-62.
32. Boivin G, Mackay I, Sloots TP, Madhi S, Freymuth F, Wolf D, et al. Global genetic diversity of human metapneumovirus fusion gene. Emerg Infect Dis 2004; 10:1154-1157.
33. Ludewick HP, Abed Y, van Niekerk N, Boivin G, Klugman KP, Madhi SA. Human metapneumovirus genetic variability. South Africa Emerg Infect Dis 2005; 11:1074-1078.
34. Mackay IM, Bialasiewicz S, Waliuzzaman Z, Chidlow GR, Fegredo DC, Laingam S, et al. Use of the P gene to genotype human metapneumovirus identifies 4 viral subtypes. J Infect Dis 2004; 190:1913-1918.
35. Winther TN, Madsen CD, Pedersen AG, von Linstow ML, Eugen-Olsen J, Hogh B. Limited inter- and intra-patient sequence diversity of the genetic lineage A human metapneumovirus fusion gene. Virus Genes 2005; 31:89-97.
36. Cuevas LE, Nasser AM, Dove W, Gurgel RQ, Greensill J, Hart CA. Human metapneumovirus and respiratory syncytial virus, Brazil. Emerg Infect Dis 2003; 9:1626-1628.
37. Walsh EE, McConnochie KM, Long CE, Hall CB. Severity of respiratory syncytial virus infection is related to virus strain. J Infect Dis 1997; 175:814-820.
38. Devincenzo JP. Natural infection of infants with respiratory syncytial virus subgroups A and B: a study of frequency, disease severity, and viral load. Pediatr Res 2004; 56:914-917.
39. Venter M, Collinson M, Schoub BD. Molecular epidemiological analysis of community circulating respiratory syncytial virus in rural South Africa: Comparison of viruses and genotypes responsible for different disease manifestations. J Med Virol 2002; 68:452-461.
40. Landry ML, Ferguson D, Cohen S, Peret TC, Erdman DD. Detection of human metapneumovirus in clinical samples by immunofluorescence staining of shell vial centrifugation cultures prepared from three different cell lines. J Clin Microbiol 2005; 43:1950-1952.
41. Sabara MI, Larence JE. Evaluation of a Japanese quail fibrosarcoma cell line (QT-35) for use in the propagation and detection of metapneumovirus. J Virol Methods 2002; 102:73-81.
42. Percivalle E, Sarasini A, Visai L, Revello MG, Gerna G. Rapid detection of human metapneumovirus strains in nasopharyngeal aspirates and shell vial cultures by monoclonal antibodies. J Clin Microbiol 2005; 43:3443-3446.
43. Ebihara T, Endo R, Ma X, Ishiguro N, Kikuta H. Detection of human metapneumovirus antigens in nasopharyngeal secretions by an immunofluorescent- antibody test. J Clin Microbiol 2005; 43:1138-1141.
44. Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Cote S, et al. Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis 2002; 186:1330-1334.
45. Mackay IM, Jacob KC, Woolhouse D, Waller K, Syrmis MW, Whiley DM, et al. Molecular assays for detection of human metapneumovirus. J Clin Microbiol 2003; 41:100-105.
46. Peret TC, Boivin G, Li Y, Couillard M, Humphrey C, Osterhaus AD, et al. Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis 2002; 185:1660-1663.
47. Viazov S, Ratjen F, Scheidhauer R, Fiedler M, Roggendorf M. High prevalence of human metapneumovirus infection in young children and genetic heterogeneity of the viral isolates. J Clin Microbiol 2003; 41:3043-3045.
48. Bouscambert-Duchamp M, Lina B, Trompette A, Moret H, Motte J, Andreoletti L. Detection of human metapneumovirus RNA sequences in nasopharyngeal aspirates of young French children with acute bronchiolitis by real-time reverse transcriptase PCR and phylogenetic analysis. J Clin Microbiol 2005; 43:1411-1414.
49. Cote S, Abed Y, Boivin G. Comparative evaluation of real-time PCR assays for detection of the human metapneumovirus. J Clin Microbiol 2003; 41:3631-3635.
50. Kuypers J, Wright N, Corey L, Morrow R. Detection and quantification of human metapneumovirus in pediatric specimens by real-time RT-PCR. J Clin Virol 2005; 33:299-305.
51. Maertzdorf J, Wang CK, Brown J, Quinto JD, Chu M, de Graaf M, et al. Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages. J Clin Microbiol 2004; 42:981-986.
52. Sumino KC, Agapov E, Pierce RA, Trulock EP, Pfeifer JD, Ritter JH, et al. Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment. J Infect Dis 2005; 192:1052-1060.
53. Bosis S, Esposito S, Niesters HG, Crovari P, Osterhaus AD, Principi N. Impact of human metapneumovirus in childhood: comparison with respiratory syncytial virus and influenza viruses. J Med Virol 2005; 75:101-104.
54. Christensen A, Nordbo SA, Jeansson S, Slordahl S. Lower respiratory tract infection caused by human metapneumovirus in two children: the first report of human metapneumovirus infection in Norway. Scand J Infect Dis 2003; 35:772-774.
55. Dollner H, Risnes K, Radtke A, Nordbo SA. Outbreak of human metapneumovirus infection in Norwegian children. Pediatr Infect Dis J 2004; 23:436-440.
56. Freymouth F, Vabret A, Legrand L, Eterradossi N, Lafay-Delaire F, Brouard J, et al. Presence of the new human metapneumovirus in French children with bronchiolitis. Pediatr Infect Dis J 2003; 22:92-94.
57. Garcia Garcia ML, Calvo RC, Martin V, Lopez Huertas MR, Casas F, Diaz-Delgado IR, et al. Respiratory infections due to metapneumovirus in hospitalized infants. An Pediatr (Barc) 2004; 61:213-218.
58. Jartti T, van den HB, Garofalo RP, Osterhaus AD, Ruuskanen O. Metapneumovirus and acute wheezing in children. Lancet 2002; 360:1393-1394.
59. Maggi F, Pifferi M, Vatteroni M, Fornai C, Tempestini E, Anzilotti S, et al. Human metapneumovirus associated with respiratory tract infections in a 3-year study of nasal swabs from infants in Italy. J Clin Microbiol 2003; 41:2987-2991.
60. Nicholson KG, McNally T, Silverman M, Simons P, Zambon MC. Influenza-related hospitalizations among young children in Leicestershire. Pediatr Infect Dis J 2003; 22:S228-S230.
61. Principi N, Esposito S, Bosis S. Human metapneumovirus and lower respiratory tract disease in children. N Eng J Med 2004; 350:1788-1790.
62. Ulloa-Gutierrez R. Human metapneumovirus: a new agent in the differential diagnosis of respiratory tract infection. An Pediatr (Barc) 2003; 59:129-130.
63. Wilczynski J, Litwinska B. Human metapneumovirus-new identified virus infecting human respiratory tract. Przegl Epidemiol 2004; 58:325-333.
64. Wolf DG, Zakay-Rones Z, Fadeela A, Greenberg D, Dagan R. High seroprevalence of human metapneumovirus among young children in Israel. J Infect Dis 2003; 188:1865-1867.
65. Xepapadaki P, Psarras S, Bossios A, Tsolia M, Gourgiotis D, Liapi-Adamidou G, et al. Human Metapneumovirus as a causative agent of acute bronchiolitis in infants. J Clin Virol 2004; 30:267-270.
66. Bastien N, Ward D, Van Caeseele P, Brandt K, Lee SH, McNabb G, et al. Human metapneumovirus infection in the Canadian population. J Clin Microbiol 2003; 41:4642-4646.
67. Boivin G, De Serres G, Cote S, Gilca R, Abed Y, Rochette L, et al. Human metapneumovirus infections in hospitalized children. Emerg Infect Dis 2003; 9:634-640.
68. Esper F, Boucher D, Weibel C, Martinello RA, Kahn JS. Human metapneumovirus infection in the United States: clinical manifestations associated with a newly emerging respiratory infection in children. Pediatrics 2003; 111:1407-1410.
69. Falsey AR, Erdman D, Anderson LJ, Walsh EE. Human metapneumovirus infections in young and elderly adults. J Infect Dis 2003; 187:785-790.
70. Robinson JL, Lee BE, Bastien N, Li Y. Seasonality and clinical features of human metapneumovirus infection in children in Northern Alberta. J Med Virol 2005; 76:98-105.
71. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Eng J Med 2004; 350:443-450.
72. Ebihara T, Endo R, Kikuta H, Ishiguro N, Ishiko H, Hara M, et al. Human metapneumovirus infection in Japanese children. J Clin Microbiol 2004; 42:126-132.
73. Ebihara T, Endo R, Kikuta H, Ishiguro N, Yoshioka M, Ma X, et al. Seroprevalence of human metapneumovirus in Japan. J Med Virol 2003; 70:281-283.
74. Peiris JS, Tang WH, Chan KH, Khong PL, Guan Y, Lau YL, et al. Children with respiratory disease associated with metapneumovirus in Hong Kong. Emerg Infect Dis 2003; 9:628-633.
75. Saez-Llorens X, Castano E, Null D, Steichen J, Sanchez PJ, Ramilo O, et al. Safety and pharmacokinetics of an intramuscular humanized monoclonal antibody to respiratory syncytial virus in premature infants and infants with bronchopulmonary dysplasia. The MEDI-493 Study Group. Pediatr Infect Dis J 1998; 17:787-791.
76. Suzuki A, Watanabe O, Nishimura H. Detection of human metapneumovirus from wheezing children in Japan (in Japanese). Kansenshogaku Zasshi 2003; 77:467-468.
77. Thanasugarn W, Samransamruajkit R, Vanapongtipagorn P, Prapphal N, van den HB, Osterhaus AD, et al. Human metapneumovirus infection in Thai children. Scand J Infect Dis 2003; 35:754-756.
78. Zhu RN, Qian Y, Deng J, Wang F, Hu AZ, Lu J, et al. Human metapneumovirus may associate with acute respiratory infections in hospitalized pediatric patients in Beijing, China. Zhonghua ErKeZa Zhi 2003; 41:441-444.
79. Druce J, Tran T, Kelly H, Kaye M, Chibo D, Kostecki R, et al. Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002-2003. J Med Virol 2005; 75:122-129.
80. Nissen MD, Siebert DJ, Mackay IM, Sloots TP, Withers SJ. Evidence of human metapneumovirus in Australian children. Med J Aust 2002; 176:188.
81. Werno AM, Anderson TP, Jennings LC, Jackson PM, Murdoch DR. Human metapneumovirus in children with bronchiolitis or pneumonia in New Zealand. J Paediatr Child Health 2004; 40:549-551.
82. Fodha I, Legrand L, Vabret A, Jrad T, Gueddiche N, Trabelsi AF, et al. Detection of human metapneumovirus in two Tunisian children. Ann Trop Paediatr 2004; 24:275-276.
83. Martinello RA, Chen MD, Weibel C, Kahn JS. Correlation between respiratory syncytial virus genotype and severity of illness. J Infect Dis 2002; 186:839-842.
84. Madhi SA, Ludewick H, Abed Y, Klugman KP, Boivin G. Human metapneumovirus-associated lower respiratory tract infections among hospitalized human immunodeficiency virus type 1 (HIV-1)-infected and HIV-1-uninfected African infants. Clin Infect Dis 2003; 37:1705-1710.
85. Smuts HE, Kannemeyer J, Smit L, Smith T. Human metapneumovirus infection in South African children hospitalised with respiratory tract disease. S Afr Med J 2004; 94:359-361.
86. IJpma FF, Beekhuis D, Cotton MF, Pieper CH, Kimpen JL, et al. Human metapneumovirus infection in hospital referred South African children. J Med Virol 2004; 73:486-493.
87. Galiano M, Videla C, Puch SS, Martinez A, Echavarria M, Carballal G. Evidence of human metapneumovirus in children in Argentina. J Med Virol 2004; 72:299-303.
88. Wilkesmann A, Schildgen O, Eis-Hubinger AM, Geikowski T, Glatzel T, Lentze MJ, Bode U, Simon A. Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections. Eur J Pediatr 2006; 165:467-475.
89. Cane PA, van den Hoogen BG, Chakrabarti S, Fegan CD, Osterhaus AD. Human metapneumovirus in a haematopoietic stem cell transplant recipient with fatal lower respiratory tract disease. Bone Marrow Transplant 2003; 31:309-310.
90. van den Hoogen BG, van Doornum GJ, Fockens JC, Cornelissen JJ, Beyer WE, de Groot R, et al. Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients. J Infect Dis 2003; 188:1571-1577.
91. Osterhaus A, Fouchier R. Human metapneumovirus in the community. Lancet 2003; 361:890-891.
92. Leung J, EsperF, Weibel C, Kahn JS. Seroepidemiology of human metapneumovirus (hMPV) on the basis of a novel enzyme-linked immunosorbent assay utilizing hMPV fusion protein expressed in recombinant vesicular stomatitis virus. J Clin Microbiol 2005; 43:1213-1219.
93. Stensballe LG, Devasundaram JK, Simoes EA. Respiratory syncytial virus epidemics: the ups and downs of a seasonal virus. J Pediatr Infect Dis 2003; 22:S21-S32.
94. Cane PA, Weber M, Sanneh M, Dackour R, Pringle CR, Whittle H. Molecular epidemiology of respiratory syncytial virus in The Gambia. Epidemiol Infect 1999; 122:155-160.
95. Peret TC, Hall CB, Hammond GW, Piedra PA, Storch GA, Sullender WM, et al. Circulation patterns of group A and B human respiratory syncytial virus genotypes in 5 communities in North America. J Infect Dis 2000; 181:1891-1896.
96. Peret TC, Hall CB, Schnabel KC, Golub JA, Anderson LJ. Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community. J Gen Virol 1998; 79:2221-2229.
97. Ebihara T, Endo R, Ishiguro N, Nakayama T, Sawada H, Kikuta H. Early reinfection with human metapneumovirus in an infant. J Clin Microbiol 2004; 42:5944-5946.
98. Alvarez R, Jones LP, Seal BS, Kapczynski DR, Tripp RA. Serological cross-reactivity of members of the Metapneumovirus genus. Virus Res 2004; 105:67-73.
99. von Linstow ML, Henrik LH, Eugen-Olsen J, Koch A, Nordmann WT, Meyer AM, et al. Scand J Infect Dis 2004. 36:578-584.
100. Heymann PW, Carper HT, Murphy DD, Platts-Mills TA, Patrie J, McLaughlin AP, et al. Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. J Allergy Clin Immunol 2004; 114:239-247.
101. Toikka P, Irjala K, Juven T, Virkki R, Mertsola J, Leinonen M, et al. Serum procalcitonin, C-reactive protein and interleukin-6 for distinguishing bacterial and viral pneumonia in children. Pediatr Infect Dis J 2000; 19:598-602.
102. Darniot M, Petrella T, Aho S, Pothier P, Manoha C. Immune response and alteration of pulmonary function after primary human metapneumovirus (hMPV) infection of BALB/c mice. Vaccine 2005; 23:4473-4480.
103. Wilkesmann A, Schildgen O, Eis-Huebinger A, Lentze M, Bode U, Simon A. Das humane Metapneumovirus als Erreger von Atemwegsinfektionen bei hospitalisierten Kindern - eine Übersicht. Klin Paed 2005 (in press).
104. Schildgen O, Geikowski T, Glatzel T, Schuster J, Simon A. Frequency of human metapneumovirus in the upper respiratory tract of children with symptoms of an acute otitis media. Eur J Pediatr 2005; 164:400-401.
105. Schildgen O, Simon A. Induction of acute otitis media by human metapneumovirus. Pediatr Infect Dis J 2005; 24:1126.
106. Schildgen O, Wilkesmann A, Simon A. Wheezing in patients with human metapneumovirus infection. J Allergy Clin Immunol 2006; 117:223.
107. Suzuki A, Watanabe O, Okamoto M, Endo H, Yano H, Suetake M, Nishimura H. Detection of human metapneumovirus from children with acute otitis media. Pediatr Infect Dis J 2005; 24:655-657.
108. Vicente D, Cilla G, Montes M, Perez-Trallero E. Human metapneumovirus and community-acquired respiratory illness in children. Emerg Infect Dis 2003; 9:602-603.
109. Vicente D, Montes M, Cilla G, Perez-Trallero E. Human metapneumovirus and chronic obstructive pulmonary disease. Emerg Infect Dis 2004; 10:1338-1339.
110. Weigl JA, Puppe W, Schmitt HJ. Can respiratory syncytial virus etiology be diagnosed clinically? A hospital-based case-control study in children under two years of age. Eur J Epidemiol 2003; 18:431-439.
111. Black CP. Systematic review of the biology and medical management of respiratory syncytial virus infection. Respir Care 2003; 48:209-231.
112. Levine DA, Platt SL, Dayan PS, Macias CG, Zorc JJ, Krief W, et al. Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections. Pediatrics 2004; 113:1728-1734.
113. Purcell K, Fergie J. Concurrent serious bacterial infections in 2396 infants and children hospitalized with respiratory syncytial virus lower respiratory tract infections. Arch Pediatr Adolesc Med 2002; 156:322-324.
114. Moulin F, Raymond J, Lorrot M, Marc E, Coste J, Iniguez JL, et al. Procalcitonin in children admitted to hospital with community acquired pneumonia. Arch Dis Child 2001; 84:332-336.
115. Takao S, Shimozono H, Kashiwa H, Matsubara K, Sakano T, Ikeda M, et al. The first report of an epidemic of human metapneumovirus infection in Japan: clinical and epidemiological study. Kansenshogaku Zasshi 2004; 78:129-137.
116. Takao S, Shimozono H, Kashiwa H, Shimazu Y, Fukuda S, Kuwayama M, et al. Clinical study of pediatric cases of acute respiratory diseases associated with human metapneumovirus in Japan. Jpn J Infect Dis 2003; 56:127-129.
117. Korppi M. Mixed microbial aetiology of community-acquired pneumonia in children. APMIS 2002; 110:515-522.
118. Korppi M. Community-acquired pneumonia in children: issues in optimizing antibacterial treatment. Paediatr Drugs 2003; 5:821-832.
119. McIntosh K. Community-acquired pneumonia in children. N Eng J Med 2002; 346:429-437.
120. Konig B, Konig W, Arnold R, Werchau H, Ihorst G, Forster J. Prospective study of human metapneumovirus infection in children less than 3 years of age. J Clin Microbiol 2004; 42:4632-4635.
121. Williams JV. Human metapneumovirus: an important cause of respiratory disease in children and adults. Curr Infect Dis Rep 7:204-210.
122. Greensill J, McNamara PS, Dove W, Flanagan B, Smyth RL, Hart CA. Human metapneumovirus in severe respiratory syncytial virus bronchiolitis. Emerg Infect Dis 2003; 9:372-375.
123. Low DE, Pichichero ME, Schaad UB. Optimizing antibacterial therapy for community-acquired respiratory tract infections in children in an era of bacterial resistance. Clin Pediatr (Phila) 2004; 43:135-151.
124. Kuiken T, van den Hoogen BG, van Riel DA, Laman JD, van Amerongen G, Sprong L, et al. Experimental human metapneumovirus infection of cynomolgus macaques (Macaca fascicularis) results in virus replication in ciliated epithelial cells and pneumocytes with associated lesions throughout the respiratory tract. Am J Pathol 2004; 164:1893-1900.
125. Alvarez R, Harrod KS, Shieh WJ, Zaki S, Tripp RA. Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies. J Virol 2004; 78:14003-14011.
126. Alvarez R, Tripp R. The immune response to human metapneumovirus is associated with aberrant immunity and impaired virus clearance in BALB/c mice. J Virol 2005; 79:5971-5978.
127. Mullins JA, Erdman DD, Weinberg GA, Edwards K, Hall CB, Walker FJ, et al. Human metapneumovirus infection among children hospitalized with acute respiratory illness. Emerg Infect Dis 2004; 10:700-705.
128. Meissner HC. Selected populations at increased risk from respiratory syncytial virus infection. Pediatr Infect Dis J 2003; 22:S40-S44.
129. McIntosh K, McAdam AJ. Human metapneumovirus-an important new respiratory virus. N Eng J Med 2004; 350:431-433.
130. Fitzgerald DA, Kilham HA. Bronchiolitis: assessment and evidence-based management. Med J Aust 2004; 180:399-404.
131. King VJ, Viswanathan M, Bordley WC, Jackman AM, Sutton SF, Lohr KN, Carey TS. Pharmacologic treatment of bronchiolitis in infants and children: a systematic review. Arch Pediatr Adolesc Med 2004; 158:127-137.
132. Scarfone RJ. Controversies in the treatment of bronchiolitis. Curr Opin Pediatr 2005; 17:62-66.
133. Cunha BA. Therapeutic implications of antibacterial resistance in community-acquired respiratory tract infections in children. Infection 2004; 32:98-108.
134. Wyde PR, Chetty SN, Jewell AM, Boivin G, Piedra PA. Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro. Antiviral Res 2003; 60:51-59.
135. Hicks KL, Chemaly RF, Kontoyiannis DP. Common community respiratory viruses in patients with cancer: more than just "common colds". Cancer 2003; 97:2576-2587.
136. Gern JE. Viral respiratory infection and the link to asthma. Pediatr Infect Dis J 2004; 23:S78-S86.
137. Ogra PL. Respiratory syncytial virus: the virus, the disease and the immune response. Paediatr Respir Rev 5(Suppl.A):S119-S126.
138. Rawlinson WD, Waliuzzaman Z, Carter IW, Belessis YC, Gilbert KM, Morton JR. Asthma exacerbations in children associated with rhinovirus but not human metapneumovirus infection. J Infect Dis 2003; 187:1314-1318.
139. Williams JV, Tollefson SJ, Heymann PW, Carper HT, Patrie J, Crowe JE. Human metapneumovirus infection in children hospitalized for wheezing. J Allergy Clin Immunol 2005; 115:1311-1312.
140. Williams JV, Crowe JE Jr, Enriquez R, Minton P, Peebles RS Jr, Hamilton RG, et al. Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults. J Infect Dis 2005; 192:1149-1153.
141. Schauer U, Hoffjan S, Bittscheidt J, Kochling A, Hemmis S, Bongartz S, Stephan V. RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life. Eur Respir J 2002; 20:1277-1283.
142. Sigurs N, Gustafsson PM, Bjarnason R, Lundberg F, Schmidt S, Sigurbergsson F, et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med 2005; 171:137-141.
143. Pelletier G, Dery P, Abed Y, Boivin G. Respiratory tract reinfections by the new human Metapneumovirus in an immunocompromised child. Emerg Infect Dis 2002; 8:976-978.
144. Schildgen O, Glatzel T, Geikowski T, Scheibner B, Matz B, Bindl L, et al. Human metapneumovirus RNA in encephalitis patient. Emerg Infect Dis 2005; 11:467-470.
145. Kashiwa H, Shimozono H, Takao S. Clinical pictures of children with human metapneumovirus infection: comparison with respiratory syncytial virus infection. Jpn J Infect Dis 2004; 57:80-82.
146. Hamelin ME, Yim K, Kuhn K, Cragin RP, Boukhvalova M, Blanco JC. Pathogenesis of human metapneumovirus lung infection in BALB/c mice and cotton rats. J Virol 2005; 79:8894-8903.
147. Macphail M, Schickli JH, Tang RS, Kaur J, Robinson C, Fouchier RA, et al. Identification of small-animal and primate models for evaluation of vaccine candidates for human metapneumovirus (hMPV) and implications for hMPV vaccine design. J Gen Virol 2004; 85:1655-1663.
148. Williams JV, Tollefson SJ, Johnson JE. Crowe Jr JE. The cotton rat (Sigmodon hispidus) is a permissive small animal model of human metapneumovirus infection, pathogenesis, and protective immunity. J Virol 2005; 79:10944-10951.
149. Laham FR, Israele V, Casellas JM, Garcia AM, Lac Prugent CM, Hoffman SJ, et al. Differential production of inflammatory cytokines in primary infection with human metapneumovirus and with other common respiratory viruses of infancy. J Infect Dis 2004; 189:2047-2056.
150. Guerrero-Plata A, Baron S, Poast JS, Adegboyega PA, Casola A, Garofalo RP. Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections. J Virol 2005; 79:10190-10199.
151. Guerrero-Plata A, Casola A, Garofalo RP. Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus. J Virol 2005; 79:14992-14997.
152. Guerrero-Plata A, Casola A, Suarez G, Yu X, Spetch L, Peeples ME, Garofalo RP. Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus. Am J Respir Cell Mol Biol 2006; 34:320-329.
153. Spann KM, Tran KC, Chi B, Rabin RL, Collins PL. Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]. J Virol 2004; 78:4363-4369.
154. Greenberg HB, Piedra PA. Immunization against viral respiratory disease: a review. Pediatr Infect Dis J 2004; 23:S254-S261.
155. Kneyber MC, Kimpen JL. Advances in respiratory syncytial virus vaccine development. Curr Opin Invest Drugs 2004; 5:163-170.
156. Olszewska W, Suezer Y, Sutter G, Openshaw PJ. Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins. Vaccine 2004; 23:215-221.
157. Skiadopoulos MH, Biacchesi S, Buchholz UJ, Amaro-Carambot E, Surman SR, Collins PL, Murphy BR. Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity. Virology 2006; 345:492-501.
158. Biacchesi S, Skiadopoulos MH, Yang L, Lamirande EW, Tran KC, Murphy BR, et al. Recombinant human Metapneumovirus lacking the small hydrophobic SH and/or attachment G glycoprotein: deletion of G yields a promising vaccine candidate. J Virol 2004; 78:12877-12887.
159. Tang RS, Mahmood K, Macphail M, Guzzetta JM, Haller AA, Liu H, et al. A host-range restricted parainfluenza virus type 3 (PIV3) expressing the human metapneumovirus (hMPV) fusion protein elicits protective immunity in African green monkeys. Vaccine 2005; 23:1657-1667.
160. McAdam AJ, Hasenbein ME, Feldman HA, Cole SE, Offermann JT, Riley AM, et al. Human metapneumovirus in children tested at a tertiary-care hospital. J Infect Dis 2004; 190:20-26.