The critical-size supraalveolar peri-implant defect model: Characteristics and use

Journal of Clinical Periodontology

Volumn 33, Issue 11, 2006, Pages 846-854

  Wikesjö, Ulf M E ^a   Susin, Cristiano ^a,b   Qahash, Mohammed ^a   Polimeni, Giuseppe ^a   Leknes, Knut N ^a,c   Shanaman, Richard H ^a   Prasad, Hari S ^d   Rohrer, Michael D ^d   Hall, Jan ^e  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSITY OF BERGEN   (Norway)

^d UNIVERSITY OF MINNESOTA   (United States)

^e Research and Development   (Sweden)

Author keywords

Animal model; BMP; Bone biomaterials; Bone morphogenetic protein; Dental implants; Dog; Growth factors; Guided bone regeneration; Tissue engineering

Indexed keywords

DIAGNOSTIC AGENT; FLUORESCENT DYE; TITANIUM;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; BIOPSY; BONE DENSITY; BONE DEVELOPMENT; BONE REGENERATION; DISEASE MODEL; DOG; IMPLANT; JAW; MALE; MANDIBLE; ORAL SURGERY; OSTEOLYSIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PLASTIC SURGERY; PREMOLAR TOOTH; RADIOGRAPHY; TIME; TOOTH EXTRACTION; TOOTH IMPLANTATION; TOOTH PROSTHESIS; WOUND HEALING;

ALVEOLAR BONE LOSS; ALVEOLAR PROCESS; ALVEOLECTOMY; ANIMALS; BICUSPID; BIOPSY; BONE DENSITY; BONE RESORPTION; DENTAL IMPLANTS; DENTAL PROSTHESIS DESIGN; DISEASE MODELS, ANIMAL; DOGS; FLUORESCENT DYES; IMPLANTS, EXPERIMENTAL; MALE; MANDIBLE; OSSEOINTEGRATION; OSTEOGENESIS; SURGICAL FLAPS; TIME FACTORS; TITANIUM; TOOTH EXTRACTION; WOUND HEALING;

EID: 33749434316     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2006.00985.x     Document Type: Article

References (39)

1. Araujo, M. G. & Lindhe, J. (2005) Dimensional ridge alterations following tooth extraction. An experimental study in the dog. Journal of Clinical Periodontology 32, 212-218.
2. Araujo, M. G., Sukekava, F., Wennström, J. L. & Lindhe, J. (2005) Ridge alterations following implant placement in fresh extraction sockets: an experimental study in the dog. Journal of Clinical Periodontology 32, 645-652.
3. Barboza, E. P., Leite Duarte, M. E., Geolás, L., Sorensen, R. G., Riedel, G. E. & Wikesjö, U. M. E. (2000) Ridge augmentation following implantation of recombinant human bone morphogenetic protein-2 in the dog. Journal of Periodontology 71, 488-496.
4. Bergenholtz, G. I., Wikesjö, U. M. E., Sorensen, R. G., Xiropaidis, A. V. & Wozney, J. M. (2006) Observations on healing following endodontic surgery in nonhuman primates (Macaca fascicularis) - effects of rhBMP-2. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 101, 116-125.
5. Boyne, P. J. (1996) Animal studies of the application of rhBMP-2 in maxillofacial reconstruction. Bone 19, 83S-92S.
6. Boyne, P. J., Nath, R. & Nakamura, A. (1998) Human recombinant BMP-2 in osseous reconstruction of simulated cleft palate defects. The British Journal of Oral and Maxillofacial Surgery 36, 84-90.
7. Caplanis, N., Sigurdsson, T. J., Rohrer, M. D. & Wikesjö, U. M. E. (1997) Effect of allogeneic, freeze-dried, demineralized bone matrix on guided bone regeneration in supra-alveolar peri-implant defects in dogs. The International Journal of Oral and Maxillofacial Implants 12, 634-642.
8. Cardaropoli, G., Araujo, M., Hayacibara, R., Sukekava, F. & Lindhe, J. (2005) Healing of extraction sockets and surgically produced augmented and non-augmented defects in the alveolar ridge. An experimental study in the dog. Journal of Clinical Periodontology 32, 435-440.
9. Cochran, D. L., Schenk, R., Buser, D., Wozney, J. M. & Jones, A. A. (1999) Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants. Journal of Periodontology 70, 139-150.
10. De Kok, I. J., Drapeau, S. J., Young, R. & Cooper, L. F. (2005) Evaluation of mesenchymal stem cells following implantation in alveolar sockets: a canine safety study. The International Journal of Oral and Maxillofacial Implants 20, 511-518.
11. Donath, K. & Breuner, G. (1982) A method for the study of undecalcified bones and teeth with attached soft tissues. The Sage-Schliff (sawing and grinding) technique. Journal of Oral Pathology 11, 318-326.
12. Ellingsen, J. E., Johansson, C. B., Wennerberg, A. & Holmén, A. (2004) Improved retention and bone-to-implant contact with fluoride-modified titanium implants. The International Journal of Oral and Maxillofacial Implants 19, 659-666.
13. Hanisch, O., Sorensen, R. G., Kinoshita, A., Spiekermann, H., Wozney, J. M. & Wikesjö, U. M. E. (2003) Effect of recombinant human bone morphogenetic protein-2 in dehiscence defects with non-submerged immediate implants: an experimental study in Cynomolgus monkeys. Journal of Periodontology 2003 74, 648-657.
14. Hanisch, O., Tatakis, D. N., Boskovic, M. M., Rohrer, M. D. & Wikesjö, U. M. E. (1997b) Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP-2. The International Journal of Oral and Maxillofacial Implants 12, 604-610.
15. Hanisch, O., Tatakis, D. N., Rohrer, M. D., Wöhrle, P. S., Wozney, J. M. & Wikesjö, U. M. E. (1997a) Bone formation and osseointegration stimulated by rhBMP-2 following subantral augmentation procedures in nonhuman primates. The International Journal of Oral and Maxillofacial Implants 12, 785-792.
16. Hunt, D. R., Jovanovic, S. A., Wikesjö, U. M. E., Wozney, J. M. & Bernard, G. W. (2001) Hyaluronan supports recombinant human bone morphogenetic protein-2 induced bone reconstruction of advanced alveolar ridge defects in dogs. A pilot study. Journal of Periodontology 72, 651-658.
17. Jovanovic, S. A., Hunt, D. R., Bernard, G. W., Spiekermann, H., Nishimura, R., Wozney, J. M. & Wikesjö, U. M. E. (2003) Long-term functional loading of dental implants in rhBMP-2 induced bone. A histologic study in the canine ridge augmentation model. Clinical Oral Implants Research 14, 793-803.
18. Jovanovic, S. A., Hunt, D. R., Bernard, G. W., Spiekermann, H., Wozney, J. M. & Wikesjö, U. M. E. (2006) Bone reconstruction following implantation of rhBMP-2 with guided bone regeneration membranes in canine alveolar ridge defects. Clinical Oral Implants Research, in press.
19. Li, X. J. & Jee, W. S. S. (2005) Integrated bone tissue anatomy and physiology. In Deng, H. -W., Liu, Y. -Z., Guo, C. -Y. & Chen, D. (eds). Current Topics in Bone Biology, pp. 11-56. Singapore: World Scientific Publishing Co.
20. Lin, L. I.-K. (1989) A concordance correlation coefficient to evaluate reproducibility. Biometrics 45, 255-268.
21. Lin, L. I.-K. (2000) A note on the concordance correlation coefficient. Biometrics 56, 324-325.
22. Mayer, M., Hollinger, J., Ron, E. & Wozney, J. (1996) Maxillary alveolar cleft repair in dogs using recombinant human bone morphogenetic protein-2 and a polymer carrier. Plastic and Reconstructive Surgery 98, 247-259.
23. Miranda, D. A. O., Blumenthal, N. M., Sorensen, R. G., Wozney, J. M. & Wikesjö, U. M. E. (2005) Evaluation of recombinant human bone morphogenetic protein-2 on the repair of alveolar ridge defects in baboons. Journal of Periodontology 76, 210-220.
24. Polimeni, G., Koo, K.-T., Qahash, M., Xiropaidis, A. V., Albandar, J. M. & Wikesjö, U.M. E. (2004) Prognostic factors for alveolar regeneration: bone formation at teeth and titanium implants. Journal of Clinical Periodontology 31, 927-932.
25. Rohrer, M. D. & Schubert, C. C. (1992) The cutting-grinding technique for histologic preparation of undecalcified bone and bone-anchored implants. Improvements in instrumentation and procedures. Oral Surgery, Oral Medicine, and Oral Pathology 74, 73-78.
26. Schmitz, J. P. & Hollinger, J. O. (1986) The critical size defect as an experimental model for craniomandibulofacial nonunions. Clinical Orthopaedics and Related Research 205, 299-308.
27. Sigurdsson, T. J., Fu, E., Tatakis, D. N., Rohrer, M. D. & Wikesjö, U. M. E. (1997) Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration. Clinical Oral Implants Research 8, 367-374.
28. Sigurdsson, T. J., Nguyen, S. & Wikesjö, U. M. E. (2001) Alveolar ridge augmentation with rhBMP-2 and bone-to-implant contact in induced bone. The International Journal of Periodontics and Restorative Dentistry 21, 461-473.
29. Takagi, K. & Urist, M. (1982) The reaction of the dura to bone morphogenetic protein (BMP) in repair of skull defects. Annals of Surgery 196, 100-109.
30. Tatakis, D. N., Koh, A., Jin, L., Wozney, J. M., Rohrer, M. D. & Wikesjö, U. M. E. (2002) Peri-implant bone regeneration using rhBMP-2/ACS in a canine model: a dose-response study. Journal of Periodontal Research 37, 93-100.
31. Toriumi, D. M., Kotler, H. S., Luxenberg, D. P., Holtrop, M. E. & Wang, E. A. (1991) Mandibular reconstruction with a recombinant bone-inducing factor. Functional, histologic, and biomechanical evaluation. Archives of Otolaryngology - Head and Neck Surgery 117, 1101-1112.
32. Wang, E. A., Rosen, V., D'Alessandro, J. S., Bauduy, M., Cordes, P., Harada, T., Israel, D. I., Hewick, R. M., Kerns, K. M., Lapan, P., Luxenburg, D. P., McQuaid, D., Moutsatos, I. K., Nove, J. & Wozney, J. M. (1990) Recombinant human bone morphogenetic protein induces bone formation. Proceedings of the National Academy of Sciences of the United States of America 87, 2220-2224.
33. Wikesjö, U. M. E., Hanisch, O., Sigurdsson, T. J. & Caplanis, N. (1999) Application of rhBMP-2 to alveolar and periodontal defects. In Lynch, S. E., Genco, R. J. & Marx, R. E. (eds). Tissue Engineering: Applications in Maxillofacial Surgery and Periodontics, pp. 269-286. Chicago: Quintessence Publishing Company.
34. Wikesjö, U. M. E., Kean, C. J. C. & Zimmerman, G. J. (1994) Periodontal repair in dogs: supraalveolar defect models for evaluation of safety and efficacy of periodontal reconstructive therapy. Journal of Periodontology 65, 1151-1157.
35. Wikesjö, U. M. E., Qahash, M., Thomson, R. C., Cook, A. D., Rohrer, M. D., Wozney, J. M. & Hardwick, W. R. (2003) Space-providing expanded polytetrafluoroethylene devices define alveolar augmentation at dental implants induced by recombinant human bone morphogenetic protein-2. Clinical Implant Dentistry and Related Research 5, 112-123.
36. Wikesjö, U. M. E., Qahash, M., Thomson, R. C., Cook, A. D., Rohrer, M. D., Wozney, J. M. & Hardwick, W. R. (2004) rhBMP-2 significantly enhances guided bone regeneration. Clinical Oral Implants Research 15, 194-204.
37. Wikesjö, U. M. E., Sorensen, R. G., Kinoshita, A. & Wozney, J. M. (2002) rhBMP -2/α-BSM® induces significant vertical alveolar ridge augmentation and dental implant osseointegration. Clinical Implant Dentistry and Related Research 4, 173-181.
38. Yudell, R. M. & Block, M. S. (2000) Bone gap healing in the dog using recombinant human bone morphogenetic protein-2. Journal of Oral and Maxillofacial Surgery 58, 761-766.
39. Zellin, G., Gritli-Linde, A. & Linde, A. (1995) Healing of mandibular defects with different biodegradable and non-degradable membranes. An experimental study in rats. Biomaterials 16, 601-609.