Carbachol increases Na+-HCO3- cotransport activity in murine colonic crypts in a M3-, Ca 2+/calmodulin-, and PKC-dependent manner

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 291, Issue 4, 2006, Pages

  Bachmann, O ^a   Reichelt, D ^a   Tuo, B ^a   Manns, M P ^a   Seidler, Ursula ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Anion secretion; Colon; Intestinal epithelium; Ion transport

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE; BICARBONATE SODIUM COTRANSPORTER; CARBACHOL; DICHLORODIHYDROFLUORESCEIN DIACETATE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; MUSCARINIC M3 RECEPTOR; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHELATION; CHOLINERGIC STIMULATION; COLON MUCOSA; CONTROLLED STUDY; CRYPT CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CALMODULIN; CARBACHOL; CHOLINERGIC AGONISTS; COLON; MICE; MICE, INBRED C57BL; PROTEIN KINASE C; RECEPTOR, MUSCARINIC M3; SODIUM-BICARBONATE SYMPORTERS;

EID: 33749428149     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00376.2005     Document Type: Article

References (57)

1. Aalkjaer C, Frische S, Leipziger J, Nielsen S, and Praetorius J. Sodium coupled bicarbonate transporters in the kidney, an update. Acta Physiol Scand 181: 505-512, 2004.
2. Abuladze N, Lee I, Newman D, Hwang J, Boorer K, Pushkin A, and Kurtz I. Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. J Biol Chem 273: 17689-17695, 1998.
3. + exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation. Am J Physiol Gastrointest Liver Physiol 28: G125-G131, 2004.
4. - cotransporter subtype pNBC1. Am J Physiol Gastrointest Liver Physiol 284: G37-G45, 2003.
5. Barmeyer C, Soroka CJ, Binder HJ, and Rajendran VM. Distinct functions of amiloride-sensitive and insensitive Na-Hco3 cotransporter (nbc) isoforms in rat proximal colon (Abstract). Chicago, IL: Digestive Disease Week 2005, no. M1552.
6. Barrett KE and Keely SJ. Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu Rev Physiol 62: 535-572, 2000.
7. + exchanger regulatory factor. J Clin Invest 104: 195-201, 1999.
8. Chew CS, Safsten B, and Flemstrom G. Calcium signaling in cultured human and rat duodenal enterocytes. Am J Physiol Gastrointest Liver Physiol 275: G296-G304, 1998.
9. 2+/ calmodulin-dependent protein kinase II, a brush border membrane protein. Proc Natl Acad Sci USA 87: 8990-8994, 1990.
10. Dharmsathaphorn K and Pandol SJ. Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell line. J Clin Invest 77: 348-354, 1986.
11. Di Mari JF, Mifflin RC, and Powell DW. The role of protein kinase C in gastrointestinal function and disease. Gastroenterology 128: 2131-2146, 2005.
12. Espiritu DJ, Bernardo AA, Robey RB, and Arruda JA. A central role for Pyk2-Src interaction in coupling diverse stimuli to increased epithelial NBC activity. Am J Physiol Renal Physiol 283: F663-F670, 2002.
13. 2: role of phosphorylation, exocytosis and protein synthesis. J Membr Biol 199: 39-49, 2004.
14. - channels: a newly emerging anion transport family. News Physiol Sci 15: 165-171, 2000.
15. - exchanger. J Biol Chem 276: 8358-8363, 2001.
16. Gross E, Fedotoff O, Pushkin A, Abuladze N, Newman D, and Kurtz I. Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini. J Physiol 549: 673-682, 2003.
17. - cotransporter stoichiometry. Am J Physiol Renal Physiol 283: F876-F887, 2002.
18. Ishibashi K, Sasaki S, and Marumo F. Molecular cloning of a new sodium bicarbonate cotransporter cDNA from human retina. Biochem Biophys Res Commun 246: 535-538, 1998.
19. Ishiguro H, Steward MC, Wilson RW, and Case RM. Bicarbonate secretion in interlobular ducts from guinea pig pancreas. J Physiol 495: 179-191, 1996.
20. + exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion. Gastroenterology 119: 406-419, 2000.
21. - uptake during colonic anion secretion (Abstract). Gastroenterology 120: A699, 2003.
22. + exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis. J Biol Chem 277: 23714-23724, 2002.
23. Kunzelmann K and Mall M. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev 82: 245-289, 2002.
24. Kunzelmann K and Mall M. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev 82: 245-289, 2002.
25. Lau KR, Donohue M, and Case RM. An ammonium pulse inhibits fluid secretion. Pflugers Arch 431: 415-418, 1996.
26. + exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent. J Physiol 556: 791-804, 2004.
27. Lindqvist SM, Sharp P, Johnson IT, Satoh Y, and Williams MR. Acetylcholine-induced calcium signaling along the rat colonic crypt axis. Gastroenterology 115: 1131-1143, 1998.
28. Matthews JB, Smith JA, and Nguyen H. Modulation of intestinal chloride secretion at basolateral transport sites: opposing effects of cyclic adenosine monophosphate and phorbol ester. Surgery 118: 147-152, 1995.
29. - influx in rat medullary thick ascending limb. J Physiol 555: 205-218, 2004.
30. - cotransporters in murine duodenum. Am J Physiol Gastrointest Liver Physiol 280: G332-G343, 2001.
31. - transport. Asymmetric effects of apical and basolateral exposure and implications for epithelial barrier function. J Clin Invest 96: 2142-2151, 1995.
32. Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, and Kurtz I. Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family. J Biol Chem 274: 16569-16575, 1999.
33. Pushkin A, Abuladze N, Newman D, Lee I, Xu G, and Kurtz I. Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family. Biochim Biophys Acta 1493: 215-218, 2000.
34. Rajendran VM, Oesterlin M, and Binder HJ. Sodium uptake across basolateral membrane of rat distal colon. Evidence for Na-H exchange and Na-anion cotransport. J Clin Invest 88: 1379-1385, 1991.
35. 3 cotransport activity in renal epithelial cells. Am J Physiol Renal Physiol 280: F844-F850, 2001.
36. - cotransport and expression of NBC1 and NBC2 in rabbit gastric parietal and mucous cells. Gastroenterology 116: 1389-1398, 1999.
37. 3 cotransporter by cAMP and Ca-dependent protein kinases. Am J Physiol Renal Fluid Electrolyte Physiol 262: F560-F565, 1992.
38. 3 cotransporter: VII. Mechanism of the cholinergic stimulation. Kidney Int 51: 1069-1077, 1997.
39. 3 cotransporter X. Role of nitric oxide and intracellular calcium. Miner Electrolyte Metab 25: 171-177, 1999.
40. Sassani P, Pushkin A, Gross E, Gomer A, Abuladze N, Dukkipati R, Carpenito G, and Kurtz I. Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter. Am J Physiol Cell Physiol 282: C408-C416, 2002.
41. Scholz W, Albus U, Counillon L, Gogelein H, Lang HJ, Linz W, Weichert A, and Scholkens BA. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 29: 260-268, 1995.
42. - conductance in rat distal colon. J Membr Biol 204: 117-127, 2005.
43. - cotransport in normal and cystic fibrosis intestine. JOP 2: 247-256, 2001.
44. - secretion. J Physiol 505: 411-423, 1997.
45. - secretion in CF. Am J Physiol Cell Physiol 276: C16-C25, 1999.
46. - cotransporters (NBC): expression and regulation in the kidney. J Nephrol 15, Suppl 5: S32-S40, 2002.
47. Song JC, Rangachari PK, and Matthews JB. Opposing effects of PKCα and PKCε on basolateral membrane dynamics in intestinal epithelia. Am J Physiol Cell Physiol 283: C1548-C1556, 2002.
48. Tosco M, Orsenigo MN, Gastaldi G, and Faelli A. Calmodulin-mediated regulation of bicarbonate and lactate transports in rat jejunum. Cell Physiol Biochem 12: 9-18, 2002.
49. Tsuganezawa H, Sato S, Yamaji Y, Preisig PA, Moe OW, and Alpern RJ. Role of c-SRC and ERK in acid-induced activation of NHE3. Kidney Int 62: 41-50, 2002.
50. Tuo BG, Chow JY, Barrett KE, and Isenberg JI. Protein kinase C potentiates cAMP-stimulated mouse duodenal mucosal bicarbonate secretion in vitro. Am J Physiol Gastrointest Liver Physiol 286: G814-G821, 2004.
51. Walker NM, Flagella M, Gawenis LR, Shull GE, and Clarke LL. An alternate pathway of cAMP-stimulated Cl secretion across the NKCC1-null murine duodenum. Gastroenterology 123: 531-541, 2002.
52. - exchanger. Cloning, tissue distribution, and functional characterization. J Biol Chem 275: 35486-35490, 2000.
53. - co-transporter in BSC-1 cells. J Biol Chem 276: 42339-42346, 2001.
54. - secretion: anomalous mole fraction behavior. Am J Physiol Gastrointest Liver Physiol 286: G14-G22, 2004.
55. Xie W, Kaetzel MA, Bruzik KS, Dedman JR, Shears SB, and Nelson DJ. Inositol 3,4,5,6-tetrakisphosphate inhibits the calmodulin-dependent protein kinase II-activated chloride conductance in T84 colonic epithelial cells. J Biol Chem 271: 14092-14097, 1996.
56. - cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant. Am J Physiol Renal Physiol 284: F41-F50, 2003.
57. Yanaka A, Muto H, Ito S, and Silen W. Effects of ammonium ion and ammonia on function and morphology of in vitro frog gastric mucosa. Am J Physiol Gastrointest Liver Physiol 265: G277-G288, 1993.