Acellular porcine and kangaroo aortic valve scaffolds show more intense immune-mediated calcification than cross-linked Toronto SPV® valves in the sheep model

Interactive Cardiovascular and Thoracic Surgery

Volumn 5, Issue 5, 2006, Pages 544-549

  Van Nooten, Guido ^a   Somers, Pamela ^a   Cornelissen, Maria ^b   Bouchez, Stefaan ^a   Gasthuys, Frank ^b   Cox, Eric ^b   Sparks, Lisa ^c   Narine, Kishan ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Calcification; Cross links; Immune response; Xenogenic scaffolds

Indexed keywords

CALCIUM; COLLAGEN; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA VALVE; ARTERY CALCIFICATION; BIOPROSTHESIS; CONFERENCE PAPER; CONTROLLED STUDY; HISTOLOGY; IMMUNE RESPONSE; IMMUNOGENICITY; KANGAROO; NONHUMAN; PRIORITY JOURNAL; SHEEP; SWINE; TISSUE ENGINEERING; XENOGRAFT;

EID: 33749406584     PISSN: 15699293     EISSN: 15699293     Source Type: Journal    
DOI: 10.1510/icvts.2006.136267     Document Type: Conference Paper

References (22)

1. Ferrans VJ, Spray TL, Billingham ME, Roberts WC. Structural changes in glutaraldehyde treated porcine heterografts used as substitute heart valves: transmission and scanning electron microscopic observations in 17 patients. Am J Cardiol 1978;41:1159-1184.
2. Grabenwoger M, Sider J, Fitzal F, Zelenka C, Windberger U, Grimm M, Moritz A, Block P, Wolner E. Impact of glutaraldehyde on calcification of pericardial bioprosthetic heart valve material. Ann Thorac Surg 1996;62:772-777.
3. Thubrikar MJ, Deck JD, Aouad J, Nolan SP. Role of mechanical stress in calcification of aortic bioprosthetic valves. J Thorac Cardiovasc Surg 1983;86:115-125.
4. Kim MK, Herrera GA, Battarbee HD. Role of glutaraldehyde in calcification of porcine aortic valve fibroblasts. Am J Pathol 1999;154:843-852.
5. Human P, Zilla P. Characterization of the immune response to valve prostheses and its role in primary tissue failure. Ann Thorac Surg 2001;71:S385-388.
6. Vesely I. Heart valve tissue engineering. Circ Res 2005;97:743-755.
7. Goldstein S, Clarke DR, Walsh SP, Black KS, O'Brien MF. Transpecies heart valve transplant: advanced studies of a bioengineered xenoautograph. Ann Thorac Surg 2000;70:1962-1969.
8. Simon P, Kasimir MT, Seebacher G, Weigel G, Ullrich R, Salzer-Muhar U, Reider E, Wolner E. Early failure of the tissue engineered porcine heart valve SYNERGRAFT™ in pediatric patients. Eur J Cardiothorac Surg 2002;21:703-710.
9. Dohmen PM, Lembcke A, Hotz H, Kivelitz D, Konertz WF. Ross operation with a tissue engineered heart valve. Ann Thorac Surg 2002;74:1438-1442.
10. Schoen FJ, Levy REJ. Calcification of bioprosthetic heart valves. In Bodnar E, Frater R, editors. Replacement cardiac valves. New York: McGraw-Hill,1992:125-148.
11. Rahimtoola SH. Choice of prosthetic heart valve for adult patients. J Am Coll Cardiol 2003;41:893-904.
12. Narine K, Kramm K, Dumont K, Jalali H, Sparks L, Segers P, Verdonck P, Van Nooten G. Hydrodynamic evaluation of kangaroo aortic valve matrices for tissue valve engineering. Artificial Organs 2006;30:432-439.
13. Booth C, Korossis SA, Wilcox HE, Watterson KG, Kearny JN, Fisher J, Ingham E. Tissue engineering of cardiac valve protheses I: development and histological characterization of an acellular porcine scaffold. J Heart Valve Dis 2002;11:457-462.
14. Zeltinger J, Landeen LK, Alexander HG, Kidd IG, Sibanda B. Development and characterization of tissue-engineered aortic valves. Tissue Engineering 2001;7:9-22.
15. De Rooster H, Cox E, Van Bree H. Prevalence and relevance of antibodies to type-I and -II collagen in synovial fluid of dogs with cranial cruciate ligament damage. Am J Vet Res 2000;61;1456-1461.
16. Huang-lee LLH, Cheung D, Nimni ME. Biochemical changes and cytotoxicity associated with the degradation of polymeric glutaraldehyde derived crosslinks. J Biomed Mater Res 1990;24:1185-1201.
17. McIntosh DB. Glutaraldehyde crosslinks Lys-492 and Arg-678 at the active site of sarcoplasmic reticulum Ca+-ATPase. J Biol Chem 1992;267:22328-22335.
18. Mohler ER III, Adam P, McClelland P, Graham L, Hathaway DR. Detection of osteopontin in calcified human aortic valves. Arterioscl Throm Vasc Biol 1997;17:547-552.
19. Ketchedian A, Krueger P, Lukoff H, Robinson E, Linthurst-Jones A, Crouch K, Wilfinbarger L, Hopkins RA. Ovine panel reactive antibody assay of HLA response to allograft bioengineered vascular scaffolds. J Thorac Cardiovasc Surg 2005;129:159-166.
20. Narine K, Chery CC, Goetghebeur E, Forsyth R, Claeys E, Cornelissen M, Moens L, Van Nooten G. Kangaroo vs. porcine aortic valves. Calcification potential after gluteraldehyde fixation. Eur Surg Res 2005;37:137-143.
21. Reider E, Seebacher G, Kasimir MT, Eichmair E, Winter B, Simon P, Weigel G. Tissue engineering of heart valves. Decellularized porcine and human valve scaffolds differ importantly in residual potential to attract monocytic cells. Circulation 2005;111:2792-2797.
22. Kasimir MT, Reider E, Seebacher G, Wolner E, Weigel G, Simon P. Presence and elimination of the xenoantigen Gal (α1,3) Gal in tissue engineered heart valves. Tissue Engineering 2005;11:1274-1280.