Capsaicin-induced activation of pulmonary vagal C fibers produces reflex laryngeal closure in the rat

Journal of Applied Physiology

Volumn 101, Issue 4, 2006, Pages 1104-1112

  Lu, I Jung ^a,b   Lee, Kun Ze ^b   Hwang, Ji Chuu ^a,b  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^b CHIHLEE INSTITUTE OF TECHNOLOGY   (Taiwan)

Author keywords

Apnea; Bradycardia; Diaphragmatic electromyogram; Glottal closure; Subglottal pressure; Thyroarytenoid electromyogram

Indexed keywords

CAPSAICIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; APNEA; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; CATHETERIZATION; CONTROLLED STUDY; DOSE RESPONSE; ELECTROMYOGRAM; FEMORAL ARTERY; FEMORAL VEIN; GLOTTIS; JUGULAR VEIN; LARYNGEAL NERVE; LARYNX; LARYNX MUSCLE; MALE; NERVE TRANSECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REFLEX; SURGICAL MICROSCOPE; TRACHEOSTOMY; VAGUS NERVE; VAGUS NERVE STIMULATION; VOCAL CORD;

ANIMALS; APNEA; BLOOD PRESSURE; BRADYCARDIA; CAPSAICIN; DIAPHRAGM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROMYOGRAPHY; GLOTTIS; HEART RATE; INJECTIONS, INTRAVENOUS; LARYNGEAL MUSCLES; MALE; RATS; RATS, WISTAR; RECURRENT LARYNGEAL NERVE; REFLEX;

EID: 33749335665     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01101.2005     Document Type: Article

References (32)

1. Bartlett D Jr. Respiratory functions of the larynx. Physiol Rev 69: 33-57, 1989.
2. Bauman NM, Sandler AD, Schmidt C, Maher JW, and Smith RJH. Reflex laryngospasm induced by stimulation of distal esophageal afferents. Laryngoscope 104: 209-214, 1994.
3. Bauman NM, Wang D, Jaffe DM, Porter MP, McCulloch TM, Smith RJH, and Sandler AD. Role of substance P in the laryngeal chemoreflex. Ann Otol Rhinol Laryngol 107: 575-580, 1998.
4. Bauman NM, Wang D, Jaffe DM, Sandler AD, and Luschei ES. Effect of intravenous substance P on laryngeal adductor activity in young dogs. Ann Otol Rhinol Laryngol 108: 112-118, 1999.
5. Bauman NM and Wang D. Laryngeal electromyographic, cardiovascular, and respiratory effects of neuropeptide injections into the nucleus tractus solitarius of rats. Ann Otol Rhinol Laryngol 113: 809-820, 2004.
6. Belvisi MG. Sensory nerves and airway inflammation: role of Aδ and C-fibers. Pulm Pharmacol Ther 16: 1-7, 2003.
7. Coleridge HM and Coleridge JC. Impulse activity in afferent vagal C-fibers with endings in the intrapulmonary airways of dogs. Respir Physiol 29: 125-142, 1977.
8. Diaz V, Kianicka I, Letourneau P, and Praud JP. Inferior pharyngeal constrictor electromyographic activity during permeability pulmonary edema in lambs. J Appl Physiol 81: 1598-1604, 1996.
9. Diaz V, Dorion D, Renolleau S, Letourneau P, Kianicka I, and Praud JP. Effects of capsaicin pretreatment on expiratory laryngeal closure during pulmonary edema in lambs. J Appl Physiol 86: 1570-1577, 1999.
10. Dutschmann M and Paton JFR. Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat. Am J Physiol Regul Integr Comp Physiol 282: R999-R1005, 2002.
11. England SJ, Bartlett D Jr, and Daubenspeck J. Influence of human vocal cord movements on airflow and resistance during eupnea. J Appl Physiol 52: 773-779, 1982.
12. Fortier PH, Reix P, Arsenault J, Dorion D, and Praud JP. Active upper airway closure during induced central apneas in lambs is complete at the laryngeal level only. J Appl Physiol 95: 97-103, 2003.
13. Green JF, Schmid ND, Schultz HD, Roberts AM, Coleridge HM, and Coleridge JCG. Pulmonary C-fibers evoke both apnea and tachypnea of pulmonary chemoreflex. J Appl Physiol 57: 562-567, 1984.
14. Ho CY, Gu Q, Lin YS, and Lee LY. Sensitivity of vagal afferent endings to chemical irritants in the rat lung. Respir Physiol 127: 113-124, 2001.
15. Insalaco G, Kuna TS, Catania G, Marrone O, Costanza BM, Bellia V, and Bonsignore G. Thyroarytenoid muscle activity in sleep apneas. J Appl Physiol 74: 704-709, 1993.
16. Kaczynska K and Szereda-Przestaszewska M. Superior laryngeal nerve section abolishes capsaicin evoked chemoreflex in anaesthetized rats. Acta Neurobiol Exp (Warsz) 62: 19-24, 2002.
17. Lai CJ and Kou YR. Stimulation of vagal pulmonary C fibers by inhaled wood smoke in rats. J Appl Physiol 84: 30-36, 1998.
18. Lee KZ, Lu IJ, Ku LC, Lin JT, and Hwang JC. Response of respiratory-related hypoglossal nerve activity to capsaicin-induced pulmonary C-fibers. J Biomed Sci 10: 706-717, 2003.
19. Lee LY, Morton RF, and Kou YR. Acute effects of cigarette smoke and breathing in rats: vagal and nonvagal mechanisms. J Appl Physiol 68: 955-961, 1990.
20. Lee LY and Pisarri TE. Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir Physiol 125: 47-65, 2001.
21. Lin YS and Kou YR. Reflex apneic response evoked by laryngeal exposure to wood smoke in rats. J Appl Physiol 83: 723-730, 1997.
22. Lu IJ, Ku LC, Lin JT, Lee KZ, and Hwang JC. Pulmonary C-fiber activation enhances respiratory-related activities of the recurrent laryngeal nerve in rats. Chin J Physiol 45: 143-154, 2002.
23. Lu IJ, Lee KZ, Lin JT, and Hwang JC. Capsaicin administration inhibits the abducent branch but excites the thyroarytenoid branch of the recurrent laryngeal nerves in the rat. J Appl Physiol 98: 1646-1652, 2005.
24. Motoyoshi K, Hyodo M, Yamagata T, and Gyo K. Restoring vocal fold movement after transaction and immediate suturing of the recurrent laryngeal nerve with local application of basic fibroblast growth factor: an experimental study in the rat. Laryngoscope 114: 1247-1252, 2004.
25. Reix P, Arsenault J, Dome V, Fortier PH, Lafond JR, Moreau-Bussiere F, Dorion D, and Praud JP. Active glottal closure during central apneas limits oxygen desaturation in premature lambs. J Appl Physiol 94: 1949-1954, 2003.
26. Sant'Ambrogio G and Widdicombe J. Reflexes from airway rapidly adapting receptor. Respir Physiol 125: 33-45, 2001.
27. Stransky A, Szereda-Prezestaszewska M, and Widdicombe JG. The effect of lung reflexes on laryngeal resistance and motoneuron discharge. J Physiol 237: 417-438, 1973.
28. Szereda-Przestaszewska M and Wypych B. Laryngeal constriction produced by capsaicin in the cat. J Physiol Pharmacol 47: 351-360, 1996.
29. Tully A, Brancatisano A, Loring SH, and Engel LA. Relationship between thyroarytenoid activity and laryngeal resistance. J Appl Physiol 68: 1988-1998, 1990.
30. Van der Velde L, Curran AK, Filiano JJ, Darnall RA, Bartlett D Jr, and Leiter JC. Prolongation of the laryngeal chemoreflex after inhibition of the rostral ventral medulla in piglets: a role in SIDS? J Appl Physiol 94: 1883-1895, 2004.
31. Zhou D, Huang Q, St John WM, and Bartlett D Jr. Respiratory activities of intralaryngeal branches of the recurrent laryngeal nerve. J Appl Physiol 67: 1171-1178, 1989.
32. Wallenstein S, Zucker CL, and Fleiss JL. Some statistical methods useful in circulation research. Circ Res 47: 1-9, 1980.