Capsaicin administration inhibits the abducent branch but excites the thyroarytenoid branch of the recurrent laryngeal nerves in the rat

Journal of Applied Physiology

Volumn 98, Issue 5, 2005, Pages 1646-1652

  Lu, I Jung ^a   Lee, Kun Ze ^a   Lin, Jin Tun ^a   Hwang, Ji Chuu ^a  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

Author keywords

Apnea; Bradycardia; Hypotension; Phrenic nerve; Superior laryngeal nerve

Indexed keywords

CAPSAICIN;

ANIMAL TISSUE; APNEA; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; DRUG MEGADOSE; HYPOTENSION; LARYNGEAL NERVE; LOW DRUG DOSE; MALE; NERVE CONDUCTION; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; SUPERIOR LARYNGEAL NERVE; VAGOTOMY;

ABDUCENS NERVE; ANIMALS; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; LARYNGEAL NERVES; MALE; NEURAL INHIBITION; PULMONARY VENTILATION; RATS; RATS, WISTAR; RESPIRATORY MUSCLES; VAGOTOMY;

EID: 17644366463     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01133.2004     Document Type: Article

References (29)

1. Bartlett DJ. Respiratory functions of the larynx. Physiol Rev 69: 33-57, 1989.
2. Belvisi MG. Sensory nerves and airway inflammation: role of Aδ and C-fibres. Pulm Pharmacol Ther 16: 1-7, 2003.
3. Coleridge HM and Coleridge JCG. Reflexes evoked from tracheobronchial tree and lungs. In Handbook of Physiology: The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 1, chapt. 12, p. 395-429.
4. Coleridge HM and Coleridge JC. Impulse activity in afferent vagal C-fibers with endings in the intrapulmonary airways of dogs. Respir Physiol 29: 125-142, 1977.
5. Diaz V, Kianicka I, Letourneau P, and Praud JP. Interior pharyngeal constrictor electromyographic activity during permeability pulmonary edema in lambs. J Appl Physiol 81: 1598-1604, 1996.
6. Diaz V, Dorion D, Renolleau S, Letourneau P, Kianicka I, and Praud JP. Effects of capsaicin pretreatment on expiratory laryngeal closure during pulmonary edema in lambs. J Appl Physiol 86: 1570-1577, 1999.
7. Dutschmann M and Paton JF. Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat. Am J Physiol Regul Integr Comp Physiol 282: R999-R1005, 2002.
8. Fortier PH, Reix P, Arsenault J, Dorion D, and Praud JP. Active upper airway closure during induced central apneas in lambs is complete at the laryngeal level only. J Appl Physiol 95: 97-103, 2003.
9. Green JF, Schmidt ND, Schultz HD, Roberts AM, Coleridge HM, and Coleridge JCG. Pulmonary C-fibers evoke both apnea and tachypnea of pulmonary chemoreflex. J Appl Physiol 57: 562-567, 1984.
10. Ho CY, Gu Q, Lin YS, and Lee LY. Sensitivity of vagal afferent endings to chemical irritants in the rat lung. Respir Physiol 127: 113-124, 2001.
11. Hwang JC, St John WM, and Bartlett D Jr. Respiratory-related hypoglossal nerve activity: influence of anesthetics. J Appl Physiol 55: 785-792, 1983.
12. Hwang JC and St John WM. Alterations of hypoglossal motoneuronal activities during pulmonary inflations. Exp Neurol 97: 615-625, 1987.
13. Lai CJ and Kou YR. Stimulation of vagal pulmonary C fibers by inhaled wood smoke in rats. J Appl Physiol 84: 30-36, 1998.
14. Lara JP, Dawid-Milner MS, Lopez MV, Montes C, Spyer KM, and Gonzalez-Baron S. Laryngeal effects of stimulation of rostral and ventral pons in the anaesthetized rat. Brain Res 934: 97-106, 2002.
15. Lee LY and Pisarri TE. Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir Physiol 125: 47-65, 2001.
16. Lee LY, Morton RF, and Kou YR. Acute effects of cigarette smoke and breathing in rats: vagal and nonvagal mechanisms. J Appl Physiol 68: 955-961, 1990.
17. Lee KZ, Lu IJ, Ku LC, Lin JT, and Hwang JC. Response of respiratory-related hypoglossal nerve activity to capsaicin-induced pulmonary C-fibers. J Biomed Sci 10: 706-717, 2003.
18. Lu IJ, Ku LC, Lin JT, Lee KZ, and Hwang JC. Pulmonary C-fiber activation enhances respiratory-related activities of the recurrent laryngeal nerve in rats. Chin J Physiol 45: 143-154, 2002.
19. Lu IJ and Hwang JC. Laryngeal response to activation of pulmonary C-fibers by capsaicin in the rat (Abstract). The Nineteenth Joint Annual Conference of Biomedical Sciences Taipei 2004, p. 400.
20. McCaffrey TV and Kern EB. Laryngeal regulation of airway resistance. II. Pulmonary receptor reflexes. Ann Otol 89: 462-466, 1980.
21. Palecek F, Sant'Ambrogio G, Sant'Ambrogio FB, and Mathew OP. Reflex responses to capsaicin: intravenous, aerosol, and intratracheal administration. J Appl Physiol 67: 1428-1437, 1989.
22. Praud JP, Diaz V, Kianicka I, and Dalle D. Active expiratory glottic closure during permeability pulmonary edema in nonsedated lambs. Am J Respir Crit Care Med 152: 732-737, 1995.
23. Reix P, Arsenault J, Dôme V, Fortier PH, Lafond JR, Moreau-Bussière F, Dorion D, and Praud JP. Active glottal closure during central apneas limits oxygen desaturation in premature lambs. J Appl Physiol 94: 1949-1954, 2003.
24. Sant'Ambrogio G and Widdicombe J. Reflexes from airway rapidly adapting receptor. Respir Physiol 125: 33-45, 2001.
25. Schelegle ES, Mansoor JK, and Green JF. Influence of background vagal C-fiber activity on eupneic breathing pattern in anesthetized dogs. J Appl Physiol 79: 600-606, 1995.
26. Stransky A, Szereda-Przestaszewska M, and Widdicombe JG. The effects of lung reflexes on laryngeal resistance and motoneuron discharge. J Physiol 231: 417-438, 1973.
27. Szereda-Przestaszewska M and Wypych B. Laryngeal constriction produced by capsaicin in the cat. J Physiol Pharmacol 47: 351-360, 1996.
28. Wallenstein S, Zucker CL, and Fleiss JL. Some statistical methods useful in circulation research. Circ Res 47: 1-9, 1980.
29. Zhou D, Huang Q, St John WM, and Bartlett D Jr. Respiratory activities of intralaryngeal branches of the recurrent laryngeal nerve. J Appl Physiol 67: 1171-1178, 1989.