Comparative effects of estradiol, raloxifene, and genistein on the uterus of ovariectomized mice

Fertility and Sterility

Volumn 86, Issue 4, 2006, Pages 1003-1005

  García Pérez, Miguel Angel ^a   Noguera, Rosa ^b   del Val, Raquel ^a   Noguera, Inmaculada ^b   Hermenegildo, Carlos ^a,b   Cano, Antonio ^b  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EOSIN; ESTRADIOL; GENISTEIN; HEMATOXYLIN; RALOXIFENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOMETRIUM; EPITHELIUM; FEMALE; HISTOLOGY; MOUSE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; STAINING; UTERUS WEIGHT;

ANIMALS; BODY WEIGHT; ESTRADIOL; FEMALE; GENISTEIN; MICE; MICE, INBRED C57BL; OVARIECTOMY; RALOXIFENE; UTERUS;

EID: 33749264392     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2006.03.029     Document Type: Article

References (14)

1. Zhang X., Shu X.O., Li H., Yang G., Li Q., Gao Y.T., et al. Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med 165 (2005) 1890-1895
2. Neven P., Quail D., Levrier M., Aguas F., The H.S., De Geyter C., et al. Uterine effects of estrogen plus progestin therapy and raloxifene: adjudicated results from the EURALOX study. Obstet Gynecol 103 (2004) 881-891
3. Awoniyi C.A., Roberts D., Veeramachaneni D.N., Hurst B.S., Tucker K.E., and Schlaff W.D. Reproductive sequelae in female rats after in utero and neonatal exposure to the phytoestrogen genistein. Fertil Steril 70 (1998) 440-447
4. Newbold R.R., Banks E.P., Bullock B., and Jefferson W.N. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61 (2001) 4325-4328
5. Lian Z., Niwa K., Tagami K., Hashimoto M., Gao J., Yokoyama Y., et al. Preventive effects of isoflavones, genistein and daidzein, on estradiol-17beta-related endometrial carcinogenesis in mice. Jpn J Cancer Res 92 (2001) 726-734
6. Erlandsson M.C., Jonsson C.A., Lindberg M.K., Ohlsson C., and Carlsten H. Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice. J Endocrinol 175 (2002) 319-327
7. Black L.J., Sato M., Rowley E.R., Magee D.E., Bekele A., Williams D.C., et al. Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest 93 (1994) 63-69
8. Sato M., Rippy M.K., and Bryant H.U. Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J 10 (1996) 905-912
9. Eason R.R., Till S.R., Velarde M.C., Geng Y., Chatman Jr. L., Gu L., et al. Uterine phenotype of young adult rats exposed to dietary soy or genistein during development. J Nutr Biochem 16 (2005) 625-632
10. Kaari C., Haidar M.A., Junior J.M., Nunes M.G., Quadros L.G., Kemp C., et al. Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study. Maturitas 53 (2006) 49-58
11. Crisafulli A., Marini H., Bitto A., Altavilla D., Squadrito G., Romeo A., et al. Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study. Menopause 11 (2004) 400-404
12. Inoue A., Takeuchi S., and Takahashi S. Insulin-like growth factor-I stimulated DNA replication in mouse endometrial stromal cells. J Reprod Dev 51 (2005) 305-313
13. Unfer V., Casini M.L., Costabile L., Mignosa M., Gerli S., and Di Renzo G.C. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 82 (2004) 145-148
14. Murray M.J., Meyer W.R., Lessey B.A., Oi R.H., DeWire R.E., and Fritz M.A. Soy protein isolate with isoflavones does not prevent estradiol-induced endometrial hyperplasia in postmenopausal women: a pilot trial. Menopause 10 (2003) 456-464