Lund therapy - Pathophysiology-based therapy or contrived over-interpretation of limited data?

Intensive Care Medicine

Volumn 32, Issue 10, 2006, Pages 1461-1463

  Andrews, Peter J D ^a   Citerio, Giuseppe ^b  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b SAN GERARDO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; PYRUVIC ACID;

BRAIN PERFUSION; CARBON DIOXIDE TENSION; EDITORIAL; HEALTH CARE PERSONNEL; HEALTH CARE POLICY; HUMAN; INTRACRANIAL PRESSURE; ISCHEMIA; LUND THERAPY; MEAN ARTERIAL PRESSURE; METABOLISM; MICRODIALYSIS; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PERFUSION PRESSURE; POSITRON EMISSION TOMOGRAPHY; PRACTICE GUIDELINE; PROPHYLAXIS; TRAUMATIC BRAIN INJURY;

BLOOD PRESSURE; BLOOD VOLUME; BLOOD-BRAIN BARRIER; BRAIN INJURIES; CEREBROVASCULAR CIRCULATION; HUMANS; INTENSIVE CARE; INTRACRANIAL PRESSURE; PRACTICE GUIDELINES; PRACTICE GUIDELINES AS TOPIC;

EID: 33749246267     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-006-0295-2     Document Type: Editorial

References (18)

1. Brain Trauma Foundation, American Association of Neurological Surgeons, Joint Section on Neurotrauma and Critical Care (2000) Methodology. J Neurotrauma 17:561-562
2. Brain Trauma Foundation, American Association of Neurological Surgeons, Joint Section on Neurotrauma and Critical Care (1996) Guidelines for the management of severe head injury. J Neurotrauma 13:641-734
3. Eker C, Asgeirsson B, Grande PO, Schalen W, Nordstrom CH (1998) Improved outcome after severe head injury with a new therapy based on principles for brain volume regulation and preserved microcirculation. Critical Care Med 26:1881-1886
4. Grande PO, Asgeirsson B, Nordstrom CH (1997) Physiologic principles for volume regulation of a tissue enclosed in a rigid shell with application to the injured brain. J Trauma Injury Infection Crit Care 42:S23-S31
5. Asgeirsson B, Grande PO, Nordstrom CH (1995) The Lund concept of post-traumatic brain oedema therapy. Acta Anaesthesiol Scand Suppl 39:103-106
6. Brain Trauma Foundation, American Association of Neurological Surgeons, Joint Section on Neurotrauma and Critical Care (2000) Recommendations for intracranial pressure monitoring technology. J Neurotrauma 17:497-506
7. Brain Trauma Foundation, American Association of Neurological Surgeons, Joint Section on Neurotrauma and Critical Care (2000) Guidelines for cerebral perfusion pressure. J Neurotrauma 17:507-511
8. Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smieleweski P, Chatfield DA, Aigbirhio F, Williams GB, Boniface S, Rice K, Clark JC, Pickard JD, Menon DK (2004) Does induced hypertension reduce cerebral ischaemia within the traumatized human brain? Brain 127:2479-2490
9. Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD (2004) Diffusion limited oxygen delivery following head injury. Crit Care Med 32:1384-1390
10. O2 positron emission tomography. Curr Opin Crit Care 12:85-89
11. Grände PO (2006) The "Lund Concept" for the treatment of severe head trauma - physiological principles and clinical application. Intensive Care Med DOI 10.1007/s00134-006-0294-3
12. Wahlstrom MR, Olivecrona M, Koskinen LOD, Rydenhag B, Naredi S (2005) Severe traumatic brain injury in pediatric patients: Treatment and outcome using an intracranial pressure targeted therapy - The Lund concept. Intensive Care Med 31:832-839
13. Fleminger S, Greenwood RJ, Oliver DL (2003) Pharmacological management for agitation and aggression in people with acquired brain injury. Cochrane database of systematic reviews (Online: Update Software)
14. Bell CC, Kelly RP (1987) Head injury with subsequent, intermittent, non-schizophrenic, psychotic symptoms and violence. JAMA 79:1139-1144
15. Contant CF, Valadka AB, Gopinath SP, Hannay HJ, Robertson CS (2001) Adult respiratory distress syndrome: a complication of induced hypertension after severe head injury. J Neurosurg 95:560-568
16. Howells T, Elf K, Jones PA, Ronne E, Piper I, Nilsson P, Andrews PJD, Enblad P (2005) Pressure reactivity as a guide in the treatment of cerebral perfusion pressure in patients with brain trauma. J Neurosurg 102:311-317
17. Miller JD (1994) Vasoconstriction as head injury treatment - right or wrong? Intensive Care Med 20:249-250;
18. comment on: Intensive Care Med; 20:260-267