Administration of prednisolone phosphate-liposomes reduces wound contraction in a rat partial-thickness wound model

Wound Repair and Regeneration

Volumn 14, Issue 5, 2006, Pages 602-607

  Richters, Cornelia D ^a   Paauw, Nanne J ^a   Mayen, Ilvy ^a   Van Bloois, Louis ^b   Metselaer, Josbert M ^b   Storm, Gert ^b   Pont, John S Du ^c   Hoekstra, Matthias J ^c   Kreis, Robert W ^c   Kamperdijk, Eduard W A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c Burns Research Institute   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DIPALMITOYLPHOSPHATIDYLCHOLINE; LIPOSOME; PHOSPHATE BUFFERED SALINE; PREDNISOLONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; ENCAPSULATION; MACROPHAGE; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; WOUND; WOUND CONTRACTION;

ADMINISTRATION, TOPICAL; ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; FIBROBLASTS; IMMUNOHISTOCHEMISTRY; LIPOSOMES; MALE; PREDNISOLONE; RATS; RATS, WISTAR; WOUND HEALING;

EID: 33749125003     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2006.00167.x     Document Type: Article

References (30)

1. DiPietro LA. Wound healing: the role of macrophages and other immune cells. Shock 1995; 4: 233-40.
2. Allgower M, Enberger GA, Sparkes BG. Burning the largest immune organ. Burns 1995; 1195: S7-47.
3. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulaion of connective tissue remodeling. Nat Rev Mol Cell Biol 2002; 3: 349-63.
4. Barnes PJ, Adcock I Anti-inflammatory actions of steroids: molecular mechanisms. TIPS 1993; 141: 436-41.
5. Ehrlich HP, Tarver H, Hunt TK. Effects of vitamin A and glucocorticoids upon inflammation and collagen synthesis. Ann Surg 1973; 177: 222-7.
6. Beer HD, Fassler R, Werner S. Glucocorticoid regulated gene expression in wound repair. Vitam Horm 2000; 59: 217-39.
7. Cutroneo KR, Rokowski R, Counts DF. Glucocorticoids and collagen synthesis: comparison of in vivo and cell culture studies. Collagen Relat Res 1981; 1: 557-68.
8. Van Rooijen N, Sanders A. Liposome mediated depletion of macrophages: mechanisms of action, preparation of liposomes and application. J Immunol Methods 1994; 174: 83-93.
9. Richters CD, du Pont JS, Mayen I, Kamperdijk EWA, Dutrieux RP, Kreis RW, Hoekstra MJ. Effects of a hydrofiber dressing on inflammatory cells in rat partial-thickness wounds. Wounds 2004; 16: 63-70.
10. Dijkstra CD, Döpp EA, Joling P, Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs; distinct macrophage subpopulations in the rat recognized by the antibodies ED1, ED2, and ED3. Immunology 1985; 54: 589-99.
11. Galiano RD, Michaels J, Dobryansky M, Levine JP, Gurtner GC. Quantitative and reproducible murine model of excisional wound healing. Wound Rep Reg 2004; 12: 485-92.
12. Metselaar JM, Wauben MH, Wagenaar-Hilbers JP, Boerman OC, Storm G. Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes. Arthritis Rheum 2003; 48: 2059-66.
13. Schmidt J, Metselaar JM, Wauben MHM, Toyka KV, Storm G, Gold R. Drug targeting by long-circulating liposomal glucocorticosteroid increases therapeutic efficacy in a model of multiple sclerosis. Brain 2004; 126: 1895-904.
14. Ceve G, Blume G. Hydrocortisone and dexamethasone in very deformable drug carriers have increased biological potency, prolonged effect, and reduced therapeutic dosage. Biochim Biophys Acta 2004; 1663: 61-73.
15. Korting HC, Zienicke H, Schäfer-Korting M, Braun-Falco O. Liposome encapsulation improves efficacy of betamethasone dipropinate in atopic eczema but not in psoriasis vulgaris. Eur J Clin Pharmacol 1990; 39: 349-51.
16. Shah M, Formean DM, Ferguson MWJ. Neutralisation of TGF-β1 and TGF-β2 or exogeneous addition of TGF-β3 to cutaneous rat wounds reduces scarring. J Cell Sci 1995; 108: 985-1002.
17. Ehrlich HP, Keefer KA, Maish GO, Myers RL, Mackay DR. Vanadate ingestion increases the gain in wound breaking strength and leads to better organized collagen fibers in rats during healing. Plastic Reconst Surg 2001; 107: 471-7.
18. Oishi Y, Fu ZW, Ohnuki Y, Kato H, Noguchi T. Molecular basis of the alteration in skin collagen metabolism in response to in vivo dexamethasone treatment: effects on the synthesis of collagen type I and III, collagenase, and tissue inhibitors of metalloproteinases. Br J Dermatol 2002; 147: 859-68.
19. Wicke C, Halliday B, Allen D, Roche NS, Scheuenstuhl H, Spencer MM, Roberts AB, Hunt TK. Effects of steroids and retinoids on wound healing. Arch Surg 2000; 135: 1265-70.
20. Vorauer-Uhl K, Fürnschlief, Wagner A, Ferko B, Katinger H. Topically applied liposome encapsulated superoxide dismutase reduces post-burn wound size and edema formation. Eur J Pharm Sci 2001; 14: 63-7.
21. Metselaar JM, Van Den Berg WB, Holthuysen AE, Wauben MH, Storm G, Van Lent PL. Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis. Ann Rheum Dis 2004; 63: 348-53.
22. Kamps JAAM, Scherphof GL. Biodistribution and uptake of liposomes in vivo. Meth Enzymol 2004; 387: 257-67.
23. Leibovich SJ, Ross R. The role of macrophages in wound repair. A study with hydrocortisone and anti macrophage serum. Am J Pathol 1975; 78: 71-100.
24. Shah M, Foreman D, Ferguson MWJ. Control of scarring in adult wounds by neutralizing antibody to transforming growth factor β. Lancet 1992; 339: 213-4.
25. Shah M, Foreman MD, Ferguson MWJ. Neutralizing antibody to TGF-β1,2 reduces cutaneous scarring in adult rodents. J Cell Sci 1994; 107: 1137-57.
26. Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JJ, Mizel DE, Anzano M, Greenwell-Wild T, Wahl SM, Deng C, Robert AB. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1999; 1: 260-6.
27. Van der Goes A, Hoekstra K, Van den Berg TK, Dijkstra CD. Dexamethasone promotes phagocytosis and bacterial killing by human monocytes/macrophages in vitro. J Leukoc Biol 2000; 67: 801-7.
28. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993; 122: 103-11.
29. Bolkenius U, Hahn D, Gressner AM, Breitkopf K, Dooley S, Wickert N. Glucocorticoids decrease the bioavailability of TGF-beta which leads to a reduced TGF-beta signaling in hepatic stellate cells. Biochem Biophys Res Commun 2004; 325: 1264-70.
30. Martin P, D'Souza D, Martin J, Grose R, Cooper L, Make R, McKercher SR. Wound healing in the PU.1 null mouse - tissue repair is not dependent on inflammatory cells. Curr Biol 2003; 13: 1122-8.