Synergistic costimulation by both B7 molecules regulates colitis pathogenesis

Annals of the New York Academy of Sciences

Volumn 1072, Issue , 2006, Pages 233-241

  Kim, Gisen ^a   Schoenberger, Stephen P ^a   Sharpe, Arlene ^b   Kronenberg, Mitchell ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

B7; Colitis; Costimulation; CTLA 4; IL 2

Indexed keywords

B7 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUTOIMMUNITY; COLITIS; CONFERENCE PAPER; CYTOKINE PRODUCTION; DISEASE SEVERITY; ENTERITIS; IMMUNE SYSTEM; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PATHOGENESIS; T LYMPHOCYTE;

EID: 33749018842     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1326.012     Document Type: Conference Paper

References (21)

1. BOISE, L.H. et al. 1995. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity 3: 87-98.
2. FRASER, J.D. et al. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251: 313-316.
3. JENKINS, M.K. et al. 1991. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J. Immunol. 147: 2461-2466.
4. NORTON, S.D. et al. 1992. The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells. J. Immunol. 149: 1556-1561.
5. GREEN, J.M. et al. 1994. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1: 501-508.
6. VAN DER MERWE, P.A. et al. 1997. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 185: 393-403.
7. WALUNAS, T.L. et al. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1: 405-413.
8. TIVOL, E.A. et al. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3: 541-547.
9. WATERHOUSE, P. et al. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270: 985-988.
10. + T cells. Immunity 7: 885-895.
11. PEREZ, V.L. et al. 1997. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6: 411-417.
12. GREENWALD, R.J. et al. 2001. CTLA-4 regulates induction of anergy in vivo. Immunity 14: 145-155.
13. DOYLE, A.M. et al. 2001. Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells. J. Exp. Med. 194: 893-902.
14. ALEGRE, M.L. et al. 1996. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J. Immunol. 157: 4762-4770.
15. BORRIELLO, F. et al. 1997. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6: 303-313.
16. + T cells. J. Exp. Med. 178: 237-244.
17. + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 5: 1461-1471.
18. + T cells. Immunity 1: 553-562.
19. FINN, P.W. et al. 1997. Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability. J. Immunol. 158: 4074-4081.
20. LINDSTEIN, T. et al. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339-343.
21. UEDA, H. et al. 2003. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423: 506-511.