Yohimbine may have a therapeutic role in prevention of suicide by regulation of glial fibrillary acidic protein expression

Medical Hypotheses

Volumn 67, Issue 6, 2006, Pages 1472-

  Emanuele, Enzo ^a   Minoretti, Piercarlo ^a   Arra, Mariarosa ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; SEROTONIN UPTAKE INHIBITOR; YOHIMBINE;

DRUG TOLERABILITY; HUMAN; LETTER; MACROGLIA; MAJOR DEPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; SUICIDAL BEHAVIOR; SUICIDE; UPREGULATION;

GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MODELS, BIOLOGICAL; SUICIDE; YOHIMBINE;

EID: 33748986163     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.06.010     Document Type: Letter

References (6)

1. Mann J.J., Apter A., Bertolote J., et al. Suicide prevention strategies: a systematic review. JAMA 294 (2005) 2064-2074
2. Sequeira A., Gwadry F.G., Ffrench-Mullen J.M., et al. Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry 63 (2006) 35-48
3. Schlicht K, Buttner A, Siedler F, et al. Comparative proteomic analysis with postmortem prefrontal cortex tissues of suicide victims versus controls. J Psychiatr Res 2006 [Epub ahead of print].
4. Garrido E., Perez-Garcia C., Alguacil L.F., and Diez-Fernandez C. The alpha2-adrenoceptor antagonist yohimbine reduces glial fibrillary acidic protein upregulation induced by chronic morphine administration. Neurosci Lett 383 (2005) 141-144
5. Sanacora G., Berman R.M., Cappiello A., et al. Addition of the alpha2-antagonist yohimbine to fluoxetine: effects on rate of antidepressant response. Neuropsychopharmacology 29 (2004) 1166-1171
6. Vogt H.J., Brandl P., Kockott G., Schmitz J.R., Wiegand M.H., Schadrack J., et al. Double-blind, placebo-controlled safety and efficacy trial with yohimbine hydrochloride in the treatment of nonorganic erectile dysfunction. Int J Impot Res 9 (1997) 155-161