Macroprolactin, big-prolactin and potential effects on the misdiagnosis of hyperprolactinemia using the Beckman Coulter Access Prolactin assay

Clinical Biochemistry

Volumn 39, Issue 10, 2006, Pages 1028-1034

  Ellis, M Jane ^a   Livesey, John H ^a   Soule, Steven G ^b  

^a Canterbury Health Laboratories Endolab   (New Zealand)

^b CHRISTCHURCH HOSPITAL   (New Zealand)

Author keywords

Big prolactin; Hyperprolactinemia; Macroprolactin; Prolactin

Indexed keywords

MACROGOL; PROLACTIN;

ARTICLE; BECKMAN COULTER ACCESS PROLACTIN ASSAY; CONTROLLED STUDY; DIAGNOSTIC ERROR; GEL FILTRATION CHROMATOGRAPHY; HORMONE DETERMINATION; HUMAN; HYPERPROLACTINEMIA; MAJOR CLINICAL STUDY; METHODOLOGY; PRECIPITATION; PRIORITY JOURNAL; REGRESSION ANALYSIS; STATISTICAL ANALYSIS; VOLUNTEER;

CHROMATOGRAPHY, GEL; DIAGNOSTIC ERRORS; EQUIPMENT AND SUPPLIES; HUMANS; HYPERPROLACTINEMIA; PROLACTIN;

EID: 33748979736     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2006.06.003     Document Type: Article

References (22)

1. Smith C.R., and Norman M.R. Prolactin and growth hormone: molecular heterogeneity and measurement in serum. Ann. Clin. Biochem. 27 (1990) 542-550
2. Fahie-Wilson M.N., John R., and Ellis A.R. Macroprolactin; high molecular mass forms of circulating prolactin. Ann. Clin. Biochem. 42 (2005) 175-192
3. Hattori N. The frequency of macroprolactinemia in pregnant women and the heterogeneity of its etiologies. J. Clin. Endocrinol. Metab. 81 (1996) 586-590
4. Bjoro T., Morkrid L., Wergeland R., et al. Frequency of hyperprolactinaemia due to large molecular weight prolactin (150-170(kD PRL). Scand. J. Clin. Lab. Invest. 55 (1995) 139-147
5. Ahlquist J.A., Fahie-Wilson M.N., and Cameron J. Variable detection of macroprolactin: a cause of apparent change in serum prolactin levels. Clin Endocrinol (Oxf) 47 (1997) 629
6. Olukoga A.O., and Kane J.W. Macroprolactinaemia: validation and application of the polyethylene glycol precipitation test and clinical characterization of the condition. Clin. Endocrinol. (Oxf) 51 (1999) 119-126
7. Sanchez-Eixeres M.R., Mauri M., Alfayate R., et al. Prevalence of macroprolactin detected by Elecsys 2010. Horm. Res. 56 (2001) 87-92
8. Leslie H., Courtney C.H., Bell P.M., Hadden D.R., McCance D.R., Ellis P.K., et al. Laboratory and clinical experience in 55 patients with macroprolactinemia identified by a simple polyethylene glycol precipitation method. J. Clin. Endocrinol. Metab. 86 (2001) 2743-2746
9. Hauache O.M., Rocha A.J., Maia A.C., Maciel R.M., and Vieira J.G. Screening for macroprolactinaemia and pituitary imaging studies. Clin. Endocrinol. (Oxf) 57 (2002) 327-331
10. Schneider W., Marcovitz S., Al-Shammari S., Yago S., and Chevalier S. Reactivity of macroprolactin in common automated immunoassays. Clin. Biochem. 34 (2001) 469-473
11. Suliman A.M., Smith T.P., Gibney J., and McKenna T.J. Frequent misdiagnosis and mismanagement of hyperprolactinemic patients before the introduction of macroprolactin screening: application of a new strict laboratory definition of macroprolactinemia. Clin. Chem. 49 (2003) 1504-1509
12. Prazeres S., Santos M.A., Ferreira H.G., and Sobrinho L.G. A practical method for the detection of macroprolactinaemia using ultrafiltration. Clin. Endocrinol. (Oxf) 58 (2003) 686-690
13. Schiettecatte J., De Schepper J., Velkeniers B., Smitz J., and Van Steirteghem A. Rapid detection of macroprolactin in the form of prolactin-immunoglobulin G complexes by immunoprecipitation with anti-human IgG-agarose. Clin. Chem. Lab. Med. 39 (2001) 1244-1248
14. Smith T.P., Suliman A.M., Fahie-Wilson M.N., and McKenna T.J. Gross variability in the detection of prolactin in sera containing big big prolactin (macroprolactin) by commercial immunoassays. J. Clin. Endocrinol. Metab. 87 (2002) 5410-5415
15. Ellis M.J., and Livesey J.H. Techniques for identifying heterophile antibody interference are assay specific: study of seven analytes on two automated immunoassay analyzers. Clin. Chem. 51 (2005) 639-641
16. Livesey J.H., and Donald R.A. Prevention of adsorption losses during radioimmunoassay of polypeptide hormones: effectiveness of albumins, gelatin, caseins, Tween 20 and plasma. Clin. Chim. Acta 123 (1982) 193-198
17. Robinson C., Fahie-Wilson M.N., and McCreanor G. Macroprolactin and the Beckman Access prolactin assay (abstract). Proc. Assoc. Clin. Biochem. Natl. Meet. (2002) 41-42
18. Vieira J.G., Tachibana T.T., Obara L.H., and Maciel R.M. Extensive experience and validation of polyethylene glycol precipitation as a screening method for macroprolactinemia. Clin. Chem. 44 (1998) 1758-1759
19. Strachan M.W., Teoh W.L., Don-Wauchope A.C., Seth J., Stoddart M., and Beckett G.J. Clinical and radiological features of patients with macroprolactinaemia. Clin. Endocrinol. (Oxf) 59 (2003) 339-346
20. Jackson R.D., Wortsman J., and Malarkey W.B. Macroprolactinemia presenting like a pituitary tumor. Am. J. Med. 78 (1985) 346-350
21. Fideleff H.L., Ruibal G., Boquete H., Pujol A., Sequera A., and Sobrado P. Macroprolactinemia in childhood and adolescence: a cause of asymptomatic hyperprolactinemia. Horm. Res. 53 (2000) 16-19
22. Vallette-Kasic S., Morange-Ramos I., Selim A., Gunz G., Morange S., Enjalbert A., et al. Macroprolactinemia revisited: a study on 106 patients. J. Clin. Endocrinol. Metab. 87 (2002) 581-588